个人简历

1992年在Tufts大学医学院获得细胞分子和发育生物学博士学位。1992年至1994年间在哈佛大学/麻省总医院完成博士后工作。自从2002年起，被聘为美国著名“常青藤”盟校之一的布朗大学终身教授，Michael G. Ehrlich MD特聘主任教授，时年38岁（为布朗大学医学院历史上最年轻的终身特聘教授）。自从2007年，主持建立了由美国国立卫生研究院（NIH）支持的杰出生物医学研究中心（COBRE），并任主任和首席负责人。此研究中心是全美八十多个杰出生物医学研究中心中，仅有的两个研究骨骼关节的中心之一。作为国际骨科关节研究的领军人物，在骨骼关节研究领域，校外研究经费在全美（美国和加拿大）排名第二。 2012年9月起担任西安交通大学前沿医学科学研究所所长兼骨骼关节疾病和治疗研究中心主任。

研究领域

骨骼发育和衰老，細胞外基质，软骨和骨组织工程，软骨和骨的机械调控，骨关节炎和其它关节退行性疾病的机制研究"研究领域包括软骨病，关节炎，骨折愈合，细胞外基质及生物力学传导的分子机制。"

近期论文

1. Proc Natl Acad Sciences USA, 87:8046-8050, 1990, (IF, 9.809) PMID:2236017
Chen, Q., Gibney, E., Fitch, J.M., Linsenmayer, C., Schmid, T.M. and Linsenmayer, T.F.
Long range movement and fibril association of type X collagen through embryonic cartilage matrix
2. J Cell Biol, 117:687-694, 1992. (IF, 9.688) PMID:1572897
Chen, Q., Linsenmayer, C., Gu, H.H., Schmid, T.M., and Linsenmayer, T.F.
Domains of type X collagen: alteration of cartilage matrix by fibril association and proteoglycan accumulation
3. Nature, 499 (7459):491-5, 2013, (IF, 42.351) PMID:23863940
Yang W, Wang J, Moore DC, Liang H, Dooner M, Wu Q, Terek RM, Chen Q, Ehrlich MG, Quesenberry PJ, Neel BG
Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signaling
4. Development, 111:191-196, 1991, (IF, 6.3) PMID:2015794
Linsenmayer, T.F., Chen, Q., Gibney, E., Gordon, M.K., Marchant, J.K., Mayne, R. and Schmid T.M.
Collagen types IX and X in the developing chick tibiotarsus: analysis of mRNAs and proteins
5. Arthritis Rheum, 48:275-276, 2003, (IF, 7.871) PMID: 11817585
Kanbe K, Takagishi K, Chen Q.
Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4 (Reply to study of SDF-1 alpha synovial fluid in early rheumatoid arthritis)
6. Arthritis Rheum, 58:3520-29, 2008, (IF, 7.871) PMID: 18975318/PMCID: 2774253
Namdari S, Wei L, Moore D, Chen, Q.
Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage
7. J Bone Miner Res, 22:318-328, 2007, (IF, 6.589) PMID: 17129169
Kanbe K, Yang X, Wei L, Sun, C, Chen Q.
Pericellular matrilins regulate activation of chondrocytes by cyclic load-induced matrix deformation
8. FASEB J, 25(12):4457-66. Epub 2011 Aug 19, 2011, (IF, 5.480) PMID:21856783/PMCID: PMC3236620
Guan YJ, Yang X, Wei L, Chen Q.
MiR-365: A mechano-sensitive microRNA stimulates chondrocyte differentiation through targeting Histone Deacetylase 4
9. Arthritis Rheum, 2012 Jul 25. doi: 10.1002/art.34645. (IF, 7.871) PMID: 22833219
Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Deng C, Chen D, Chen L.
Genetic inhibition of FGFR1 in cartilage attenuates articular cartilage degeneration in adult mice
10. Arthritis Rheum, 2014, 66(7):1843-53. doi: 10.1002/art.38576. (IF, 7.871) PMID:24578232
Wang S, Wei X, Zhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB, Ehrlich MG, Zhang G, Wei L. Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis