研究领域

研究兴趣集中在纳米材料功能化修饰对生物效应的影响及机制，开展了：(1)多肽纳米核酸及药物传递的系列研究，研究为利用多肽修饰设计具有溶酶体逃逸机制的纳米药物传递系统提供了重要科学依据。（2）碳基纳米材料（碳纳米管、富勒烯及石墨烯）改性及生物效应的研究，研究为碳基纳米材料的功能化修饰及生物效应提供重要理论支撑，对合理改性该类纳米材料提供理论指导。"研究兴趣集中在纳米材料功能化修饰对生物效应的影响及机制，开展了：(1)多肽纳米核酸及药物传递的系列研究，研究为利用多肽修饰设计具有溶酶体逃逸机制的纳米药物传递系统提供了重要科学依据。（2）碳基纳米材料（碳纳米管、富勒烯及石墨烯）改性及生物效应的研究，研究为碳基纳米材料的功能化修饰及生物效应提供重要理论支撑，对合理改性该类纳米材料提供理论指导。工作得到国家自然科学基金和留学回国基金及福建省自然科学基金的资助；同时还参与了多项国家自然科学基金面上项目和重点项目的研究。"

近期论文

1. Shefang Ye, Peiyan Yang, Keman Cheng, Tong Zhou, Yange Wang, Zhenqing Hou, Yuanqin Jiang, and Lei Ren. Drp1-Dependent Mitochondrial Fission Mediates Toxicity of Positively Charged Graphene in Microglia. ACS Biomaterials Science & Engineering DOI: 10.1021/acsbiomaterials.5b00465. 2. Shefang Ye, Tong Zhou, Dongmei Pan, Yiquan Lai, Peiyan Yang, Mingliang Chen, Yange Wang, Zhenqing Hou, Lei Ren, Yuanqin Jiang. Fullerene C60 derivatives attenuated microglia-mediated prion peptide neurotoxicity. 2016. Journal of Biomedical Nanotechnology, in press. 3. Shefang Ye, Ning Kang, Min Chen, Caiding Wang, Tianxiao Wang, Yarun Wang, Yongliang Liu, Donghui Li, and Lei Ren. Tat/HA2 Peptides Conjugated AuNR@pNIPAAm as a Photosensitizer Carrier for Near Infrared Triggered Photodynamic Therapy. Molecular Pharmaceutics 2015 12 (7), 2444-2458. 4. Shefang Ye, Tong Zhou, Keman Cheng, Mingliang Chen, Yange Wang, Yuanqin Jiang, Peiyan Yang. Carboxylic Acid Fullerene (C60) Derivatives Attenuated Neuroinflammatory Responses by Modulating Mitochondrial Dynamics. Nanoscale Res Lett. 2015, 10(1): 953 5. Cuilin Lin, Yifang Wang, Youqun Lai, Wei Yang, Fei Jiao, Honggang Zhang, Shefang Ye, Qiqing Zhang. Incorporation of carboxylation multiwalled carbon nanotubes into biodegradable poly(lactic-co-glycolic acid) for bone tissue engineering, Colloids and Surfaces B: Biointerfaces, 2011, 83: 367-375. 6. Shefang Ye, Miaomiao Tian, Tianxiao Wang, Lei Ren, Dong Wang, Lihua Shen, Ting Shang. Synergistic Effects of Cell Penetrating Peptide Tat and Fusogenic Peptide HA2 Enhance Cellular Internalization and Gene Transduction of Organosilica Nanoparticles. Nanomedicine, 2012, 8(6): 833-841 7. Xiangrui Yang, Shichao Wu, Yange Wang, Yang Li, Di Chang, Yin Luo, Shefang Ye, Zhenqing Hou. Evaluation of self-assembled HCPT-loaded PEG-b-PLA nanoparticles by comparing with HCPT-loaded PLA nanoparticles Nanoscale Research Letters, 2014, 9:687 8. Shefang Ye, Min Chen, Yuanqin Jiang, Mingliang Chen, Tong Zhou, Yange Wang, Zhenqing Hou, Lei Ren. Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system. Int J Nanomedicine. 2014, 9:2073-87 9. Yuanqin Jiang, Honggang Zhang, Yange Wang, Min Chen, Shefang Ye, Zhenqing Hou, Lei Ren. Modulation of apoptotic pathways of macrophages by surface-functionalized multi-walled carbon nanotubes. PLoS One, 2013, 8(6): e65756 10. Shefang Ye, Honggang Zhang, Yifang Wang, Fei Jiao, Cuilin Lin, Qiqing Zhang. Carboxylated single-walled carbon nanotubes induce an inflammatory response in human primary monocytes through oxidative stress and NF-B activation. Journal of Nanoparticle Research, 2011, 13(9): 4239-4252. 11. Yuanqing Jiang, Zhong Ouyang, Honggang Zhang, Yifang Wang, Ning Kang, Cuilin Lin, Zhenqing Hou, Shefang Ye, Lei Ren. A molecular basis for enhanced behavior of MC3T3-E1 cells on poly(lactic-co-glycolic acid)-multi-wall carbon nanotubes nanocomposite. Current Nanoscience, 2012, 8(4): 587-597 12. Shefang Ye, Yuanqing Jiang, Honggang Zhang, Yinfang Wang, Yihui Wu, Zhenqing Hou, Qiqing Zhang. Multi-wall carbon nanotubes induces apoptosis in RAW 264.7 cell-derived osteoclasts through mitochondria-mediated death pathway. Journal of Nanoscience and Nanotechnology, 2012, 12(3): 2101-2112 13. Shefang Ye, Yifang Wang, Honggang Zhang, Cuilin Lin, Yihui Wu, Qiqing Zhang. Role of NADPH oxidase in multi-wall carbon nanotubes-induced oxidative stress and cytotoxicity in human macrophages. Journal of Nanoscience and Nanotechnology 2011, 5(11): 3773-3781 14. Cuilin Lin, Yifang Wang, Youqun Lai, Wei Yang, Fei Jiao, Honggang Zhang, Shefang Ye and Qiqing Zhang. Incorporation of carboxylation multiwalled carbon nanotubes into biodegradable poly(lactic-co-glycolic acid) for bone tissue engineering. Colloids and Surfaces B: Biointerfaces, 2011, 83(2): 367-375. 15. Shefang Ye, Wen Wen, Yifang Wang, Cuilin Lin, Yihui Wu, Qiqing Zhang. Multi-walled carbon nanotubes induces nuclear factor-B activation in A549 Cells. Chemical Journal of Chinese Universities, 2010, 31(3): 497-501. 16. Fei Cui, Jinyan Lin, Yang Li, Yanxiu Li, Hongjie Wu, Fei Yu, Mengmeng Jia, Xiangrui Yang, Shichao Wu, Liya Xie, Shefang Ye, Fanghong Luo, and Zhenqing Hou. Bacillus-Shape Design of Polymer Based Drug Delivery Systems with Janus-Faced Function for Synergistic Targeted Drug Delivery and More Effective Cancer Therapy. Molecular Pharmaceutics 2015 12 (4), 1318-1327. 17. Yang Li, Jinyan Lin, Xiangrui Yang, Yanxiu Li, Shichao Wu, Yu Huang, Shefang Ye, Liya Xie, Lizong Dai, and Zhenqing Hou. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug–Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release. ACS Applied Materials & Interfaces 2015 7 (32), 17573-17581. 18. Zhenqing Hou, Yang Li, Yuancan Huang, Chunxiao Zhou, Jinyan Lin, Yixiao Wang, Fei Cui, Shuifan Zhou, Mengmeng Jia, Shefang Ye, and Qiqing Zhang.Phytosomes Loaded with Mitomycin C–Soybean Phosphatidylcholine Complex Developed for Drug Delivery. Molecular Pharmaceutics 2013 10 (1), 90-101 19. Xiangrui Yang, Shichao Wu, Yang Li, Yu Huang, Jinyan Lin, Di Chang, Shefang Ye, Liya Xie, Yuan Jiang and Zhenqing Hou. Integration of an anti-tumor drug into nanocrystalline assemblies for sustained drug release. Chem. Sci., 2015, 6, 1650-1654 20. Jinyan Lin, Yang Li, Hongjie Wu, Xiangrui Yang, Yanxiu Li, Shefang Ye, Zhenqing Hou and Changjian Lin. Tumor-targeted co-delivery of mitomycin C and 10-hydroxycamptothecin via micellar nanocarriers for enhanced anticancer efficacy. RSC Adv., 2015, 5, 23022-23033