个人简历

2007年8月起：厦门大学全职教授并任美国Scripps研究所兼职教授
2001年11至2007年7月：兼任厦门大学教授
1993至2007：历任美国Scripps研究所助理教授、副教授、教授
1990至1992：德克萨斯大学西南医学中心博士后
1990：获布鲁塞尔大学博士学位
1982和1985年：获北京大学学士和硕士学位
获奖情况
1991 比利时Jean Stas奖
1995 美国心脏协会成熟研究员奖
2009 药明康德生命化学研究奖一等奖
2009 卢嘉锡优秀导师奖
2011 教育部自然科学研究一等奖
2011 厦门市优秀归国人员
2012 福建省优秀博士论文一等奖
2012 全国优秀博士论文
2012 厦门市五一劳动奖章
2012 厦门大学南强特等奖
2012 中国侨界贡献奖
2013 第六届谈家桢生命科学成就奖
2013 国家自然科学二等奖
2014 福建省优秀科技工作者
2014 赛诺菲-Cell Research优秀论文奖
2014 全国优秀科技工作者
2015 福建省科技重大贡献奖
2017 首届全国创新争先奖

近期论文

Zhang X, Fan L, Wu J, Xu H, Leung WY, Fu K, Wu J, Liu K, Man K, Yang X, Han J, Ren J, Yu J. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. J Hepatol. 2019 Mar 23. pii: S0168-8278(19)30184-9. doi: 10.1016/j.jhep.2019.03.014. [Epub ahead of print]
Meng R, Gu L, Lu Y, Zhao K, Wu J, Wang H, Han J, Tang Y, Lu B. High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice. J Biol Chem. 2019 Apr 18. pii: jbc.RA118.007040. doi: 10.1074/jbc.RA118.007040. [Epub ahead of print]
Yang D, Liang Y, Zhao S, Ding Y, Zhuang Q, Shi Q, Ai T, Wu SQ, Han J. ZBP1 mediates interferon-induced necroptosis. Cell Mol Immunol. 2019 May 10. doi: 10.1038/s41423-019-0237-x. [Epub ahead of print]
Wu X, Yang D, Zhao F, Yang ZH, Wang D, Qiao M, Fang Y, Li W, Wu R, He P, Cong Y, Chen C, Hu L, Yan Y, Xie C, Wu Y, Han J, Zhong CQ. Quantification of dynamic protein interactions and phosphorylation in LPS signaling pathway by SWATH-MS. Mol Cell Proteomics. 2019 Mar 8. pii: mcp.RA119.001380. doi: 10.1074/mcp.RA119.001380. [Epub ahead of print]
Xue Z, Zhao H, Zhu R, Chen C, Cao H, Han J, Han S. On the use of abiotic sialic acids to attenuate cell inflammation. Sci Rep. 2018 Nov 23; 8(1): 17320.
Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 2018 Dec; 28(12): 1171-1185.
Zhu R, Wang S, Xue Z, Han J, Han S. Senescence-associated sialidase revealed by an activatable fluorescence-on labeling probe. Chem Commun (Camb). 2018 Oct 11; 54(82): 11566-11569.
Xue Z, Wang S, Li J, Chen X, Han J, Han S. Bifunctional Super-resolution Imaging Probe with Acidity-Independent Lysosome-Retention Mechanism. Anal Chem. 2018 Oct 2; 90(19): 11393-11400.
Su W, Hong L, Xu X, Huang S, Herpai D, Li L, Xu Y, Truong L, Hu WY, Wu X, Xiao C, Zhang W, Han J, Debinski W, Xiang R, Sun P. miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways. Oncogene. 2018 Oct; 37(42): 5618-5632.
Xue Z, Zhang E, Liu J, Han J, Han S. Bioorthogonal Conjugation Directed by a Sugar-Sorting Pathway for Continual Tracking of Stressed Organelles. Angew Chem Int Ed Engl. 2018 Aug 6; 57(32): 10096-10101.
Qiu X, Zhang Y, Han J. RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis. Cell Death Differ. 2018 Mar 9. doi: 10.1038/s41418-018-0075-x. [Epub ahead of print]
Xue Z, Zhu R, Wang S, Li J, Han J, Liu J, Han S. Organelle-Directed Staudinger Reaction Enabling Fluorescence-on Resolution of Mitochondrial Electropotentials via a Self-Immolative Charge Reversal Probe. Anal Chem. 2018 Feb 20;90(4):2954-2962.
Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J. RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis. Nat Cell Biol. 2018 Feb; 20(2): 186-197.
Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J. RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis. Nat Cell Biol. 2018 Jan 22. doi: 10.1038/s41556-017-0022-y. [Epub ahead of print]
Zhang Y, Chen X, Gueydan C, Han J. Plasma membrane changes during programmed cell deaths. Cell Res. 2017 Oct 27. doi: 10.1038/cr.2017.133. [Epub ahead of print]
Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8): 996-1002.
Xue Z, Zhao H, Liu J, Han J, Han S. Imaging Lysosomal pH Alteration in Stressed Cells with a Sensitive Ratiometric Fluorescence Sensor. ACS Sens. 2017 Mar 24;2(3):436-442.
Zhang Z, Meszaros G, He WT, Xu Y, de Fatima Magliarelli H, Mailly L, Mihlan M, Liu Y, Puig Gámez M, Goginashvili A, Pasquier A, Bielska O, Neven B, Quartier P, Aebersold R, Baumert TF, Georgel P, Han J, Ricci R. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017 Sep 4; 214(9): 2671-2693.
Ren J, Jia X, Zhao Y, Shi W, Lu J, Zhang Y, Wu J, Liang B, Wu R, Fu G, Han J. The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells. Cell Mol Immunol. 2017 Jul; 14(7): 639-642.
Journal of Biological Chemistry编委
International Immunopharmacology编委
Protein & Cell 编委
中国癌症研究 编委
美国分子生物学及生物化学学会会员（American Society for Molecular Biology and Biochemistry）
美国免疫学协会会员（The American Association of Immunologists）
美国微生物学协会会员（American Society for Microbiology）
国际内毒素协会会员（International Society of Endotoxin）
中国遗传学会国际交流委员会 委员
中国生物化学与分子生物学学会蛋白质专业委员会 副主任委员
中国细胞生物协会 副理事长