个人简历

博士，校聘研究员。美国纽约大学生物化学与分子药理学系博士后，温州市“海外精英引进计划”创新长期项目人才。主要从事药物化学及结构生物学相关研究。
教育经历
2006.09-2010.06，温州医科大学，获学士学位
2010.09-2013.06，温州医科大学，获硕士学位
2013.09-2016.06，温州医科大学，获博士学位

研究领域

疾病发生发展过程中的信号调控分子机制研究及相关药物开发"承担科研项目情况
1.国家自然科学青年基金，81703352，靶向作用于FGFR1膜外端结构域的新型小分子抑制剂及初步分子机制研究，2018年-2021年，主持。"

近期论文

1.GaozhiChen#,YangLiu#,ReginaGoetz,LiliFu,SeetharamanJayaraman,Ming-ChangHu,OrsonW.Moe,GuangLiang,XiaokunLi*,MoosaMohammadi*.a-Klothoisanon-enzymaticmolecularscaffoldforFGF23hormonesignalling.Nature,2018,553(7689):461-466.
2.GaozhiChen,Yalizhang,XingLiu,QiluFang,ZheWang,LiliFu,ZhiguoLiu,YiWang,YunjieZhao,XiaokunLi,GuangLiang*.Discoveryofanewinhibitorofmyeloiddifferentiation2fromcinnamamidederivativeswithanti-inflammatoryactivityinsepsisandacutelunginjury.JournalofMedicinalChemistry,2016,59(6):2436–2451.
3.GaozhiChen#,BingXiao#,LingfengChen#,BinBai,YaliZhang,ZhengXu,LiliFu,ZhiguoLiu,XiaokunLi*,YunjieZhao*,GuangLiang*.DiscoveryofnewMD2-targetedanti-inflammatorycompoundsforthetreatmentofsepsisandacutelunginjury.Europeanjournalofmedicinalchemistry,2017,139:726-740.
4.GaozhiChen,ZhiguoLiu,YaliZhang,XiaoouShan,LiliJiang,YunjieZhao,WenfeiHe,ZhiguoFeng,ShulinYang,GuangLiang*.Synthesisandanti-inflammatoryevaluationofnovelbenzimidazoleandimidazopyridinederivatives.ACSMedicinalChemistryLetters,2012,4(1):69–74.
5.GaozhiChen#,QiaoyouWeng#,LiliFu,ZheWang,PengtianYu,ZhiguoLiu,XiaokunLi,HuajieZhang*,GuangLiang*.Synthesisandbiologicalevaluationofnoveloxindole-basedRTKinhibitorsasanti-canceragents.Bioorganic&MedicinalChemistry,2014,22(24):6953–6960.