个人简历

EudaldCasalsMercadal，男，西班牙籍，特聘教授，申请人长期从事材料科学、化学以及生物医学等方面的科研工作：曾在西班牙巴塞罗那ICN2研究所的纳米材料方向从事研究工作7年，在芬兰奥伯学术大学从事药物医学研究2年，在欧洲最大的同步辐射中心ESRF技术交流6个月。目前主要从事的研究方向是无机纳米粒子的合成（包括金属，金属氧化物，双金属，杂化物，核-壳，中空粒子等）、产业化及其在医疗，可再生能源，环境修复和纳米安全等方面的应用。Casals教授于2004年西班牙NavarraUniversity(全国私立大学排名第一)获得生物化学和哲学双学士学位，随后到西班牙加泰罗尼亚纳米科技研究所(ICN2)深造，于2012年获得生物化学、分子生物学以及生物医学博士学位后在该所任实验工程师(永久职位)，2017年受聘于巴塞罗那Valld’HebronResearchInstitute任高级研究员。在国际学术期刊发表SCI论文51篇(IF>5的23篇)，他引次数超过3000(近四年增长率：20%/年)，单篇最高引用>650，7篇文章的单篇他引次数>100，H-index为24(GoogleScholar数据)，撰写书籍章节3部及大学教科书1部（作为哥伦比亚Javeriana大学在纳米材料专业的教科书）。申请人参与欧洲和西班牙科研项目共16个（≈700万欧元），参加重要学术会议并口头报告10多次，并2次受邀到世界知名的纳米创新国际会议做报告。申请人拥有欧美专利1项，以发明人以及三位创始人之一的身份成功进行了科技成果转化并创立了纳米科技公司。
教育经历
2004年获西班牙纳瓦拉大学（UniversidaddeNavarra），本科双学位（哲学和生物化学）
2009年获西班牙加泰罗尼亚纳米技术研究所（CatalanInstituteofNanotechnology），硕士
2012年获西班牙巴塞罗那自治大学，博士
工作经历
2005年09月至2006年10月，西班牙加泰罗尼亚国际大学(UniversitatInternationaldeCatalunya)，研究助理员
2011年01月至2011年06月，法国欧洲同步辐射中心(EuropeanSynchrotronRadiationFacility)，技术员
2012年02月至2014年12月，西班牙加泰罗尼亚纳米技术研究所（CatalanInstituteofNanotechnology），实验工程师
2015年01月至2016年12月，芬兰奥伯学术大学(AboAkademiUniversity)，助理研究员
2017年01月至2018年11月，西班牙巴塞罗那瓦尔德希伯伦德研究生（Vall’dHerbronResearchInstitute），高级研究员
2018年11月-至今，在五邑大学生物科技与大健康学院特聘教授
讲授课程
本科生：《IntroductiontoNanomedicine纳米医学概论》和《高分子材料》
研究生：《药用高分子材料》
发表的书本和章节
4.Gonzalez,E.,Puntes,V.,Casals,E.Nanomateriales.ParticulasColoidales.In:SeriedeNanocienciayNanotecnologia;Ed.EdgarE.Gonzalez.NanoscaleScienceangTechnologyCentre,Bogota,Colombia.2015.ISBN:978-958-46-6931-5.
3.Casals,E.,González,E.,Puntes,V.,InorganicNanoparticlesandtheEnvironment:BalancingBenefitsandRisks.InAnalysisandRiskofNanomaterialsinEnvironmentalandFoodSamples;DamiàBarcelóandMarinellaFarré,editors.Vol.59,Elsevier,2012,pp.265-290.ISBN:978-0-444-56328-6
2.Bastús,N.G.,Casals,E.,Ojea,I.,Varon,M.,Puntes1,V.TheReactivityofColloidalInorganicNanoparticles.In:Nanoparticles/Book2.Ed:Dr.AbbassHashim,In-Techd.o.o.,2012.ISBN979-953-307-859-4.
1.PaulR.,BotetJ.R.,PaletD.,CasalsE.,BautistaL.,Garcia-FernandezL.,Garrido-FrancoM.,García-MontañoJ.,DeLaFuenteM.,AmantiaD.,AubouyL.,DelavargaM.,MarsalF.,PuntesV.Nano-finishingofcottonyarnsandfabrics.In:Monograph-InnovativeMaterials&TechnologiesinMade-upTextileArticlesandFootwear,Eds:FrydrychI.,PawlowaM.TechnicalUniversityofLodz,FacultyofMaterialTechnologiesandTextileDesign,Lodz91-97,2008.ISBN978-83-7283-265-8.

研究领域

新型纳米颗粒的合成表征、纳米材料安全性和生物环境毒性的研究
纳米颗粒在环境生物修复新技术方面、工业催化剂以及纳米医药材料的研究

近期论文

2018年
52.Casals,E.,Gusta,M.F.,Montana,L.,Mendoza,M.,Maiz,N.,Carreras,E.,Puntes,V.NanotechnologyforMaternalFoetalMedicine.InternationalJournalofPediatricsandNeonatalHealthacceptedfortheVolume2Issue5,May2018.
51.Slita,A.,Egorova,A.,Casals,E.,Kiselev,A.,Rosenholm,J.M.CharacterizationofmodifiedmesoporoussilicananoparticlesasvectorsforsiRNAdelivery.AsianJournalofPharmaceuticalSciences.InPress,AcceptedManuscript(2018).(doi:10.1016/j.ajps.2018.01.006)
2017年
50.Li,Y.,Shi,Z.,Radauer-Preiml,I.,Andosch,A.,Casals,E.,Luetz-Meindl,U.,Cobaleda,M.,Lin,Z.,Jaberi-Douraki,M.,Italiani,P.,Horejs-Hoeck,J.,Himly,M.,Monteiro-Riviere,N.A,Duschl,A.,Puntes,V.F.,Boraschi,D.Bacterialendotoxin(lipopolysaccharide)bindstothesurfaceofgoldnanoparticles,interfereswithbiocoronaformationandinduceshumanmonocyteinflammatoryactivation.Nanotoxicology.11(9-10),1157-1175,(2017).(doi:10.1080/17435390.2017.1401142)
49.Casals,E.,Gusta,M.F.Cobaleda-Siles,M.,Garcia-Sanz,A.,Puntes,V.F.Cancerresistancetotreatmentandantiresistancetoolsofferedbymultimodalmultifunctionalnanoparticles.CancerNanotechnol.8(1):7,(2017),(doi:10.1186/s12645-017-0030-4)
48.Barbero,F.,Russo,L.,Vitali,M.,Piella,J.,Salvo,I.,Borrajo,M.L.,Busquets-Fité,M.,Grandori,R.,Bastús,N.G.,Casals,E.,Puntes,V.FormationoftheProteinCorona:TheInterfacebetweenNanoparticlesandtheImmuneSystem.SeminarsinImmunology,34,52-60,(2017)(https://doi.org/10.1016/j.smim.2017.10.001.)
47.Paatero,I.,Casals,E.,Niemi,R.,Özliseli,E.,Rosenholm,J.M.,Sahlgren,C.Analysesinzebrafishembryosrevealthatnanotoxicityprofilesaredependentonsurface-functionalizationcontrolledpenetranceofbiologicalmembranes.ScientificReports7:8423,(2017).(doi:10.1038/s41598-017-09312-z)
46.Casals,E.,Gusta,M.F.,Piella,J.,Casals,G.,Jimenez,W.,Puntes,V.IntrinsicandExtrinsicPropertiesAffectingInnateImmuneResponsestoNanoparticles:TheCaseofCeriumOxide.Front.Immunol.8:970,(2017).(doi:10.3389/fimmu.2017.00970)
45.García-Fernández,L.,Garcia-Pardo,J.,Tort,O.,Prior,I.,Brust,M.,Casals,E.,Lorenzo,J.,Puntes,V.F.ConservedeffectsandalteredtraffickingofCetuximabantibodiesconjugatedtogoldnanoparticleswithprecisecontroloftheirnumberandorientation.Nanoscale.9(18),6111-6121,(2017).(doi:10.1039/c7nr00947j.)
44.Pozharitskaya,O.N.,Karlina,M.V.,Shikov,A.N.,Kosman,V.M.,Makarov,V.G.,Casals,E.,Rosenholm,J.M.PharmacokineticsandTissueDispositionofNanosystem-EntrappedBetulinAfterEndotrachealAdministrationtoRats.EurJDrugMetabPharmacokinet.42(2),327-332,(2017).(doi:10.1007/s13318-016-0340-7.)
2016年
43.Prabhakar,N.,Zhang,J.,Desai,D.,Casals,E.,Gulin-Sarfraz,T.,Näreoja,T.,Westermarck,J.,Rosenholm,J.M.Stimuli-responsivehybridnanocarriersbycontrollableintegrationofhyperbranchedPEIonmesoporoussilicananoparticlesforsustainedintracellularsiRNAdelivery.InternationalJournalofNanomedicine.11,6591–6608,(2016)(doi:10.2147/IJN.S120611)
42.Li,Y.,Italiani,P.,Casals,E.,Valkenborg,D.,Mertens,I.,Baggerman,G.,Nelissen,I.,Puntes,V.F.,Boraschi,D.AssessingtheImmunosafetyofEngineeredNanoparticleswithaNovelinVitroModelBasedonHumanPrimaryMonocytes.ACSAppliedMaterials&Interfaces.8(42),28437-28447,(2016)(https://doi.org/10.1021/acsami.6b06278)
41.LeJoncour,V.,Hyvönen,M.,Casals,E.,Filppu,P.TanjoreRamanathan,J.,Ayo,A.,Westermarck,J.,Rosenholm,J.M.,Laakkonen,P.Treatingmalignantgliomaandbrainmetastasiswithnanoparticles:Challengesofapeptide-basedtargetingandpassagethroughtheblood–brain-barrier.EuropeanJournalofCancer,61,S194,2016.(https://doi.org/10.1016/S0959-8049(16)61686-6)
40.Oró,D.,Yudina,T.,Fernández-Varo,G.,Casals,E.,Reichenbach,V.,Casals,G.,Presa,B.,Sandalinas,S.,Carvajal,S.,Puntes,V.,Jiménez,W.Ceriumoxidenanoparticlesreducesteatosis,portalhypertensionanddisplayanti-inflammatorypropertiesinratswithliverfibrosis.Journalofhepatology64(3),691-698,(2016).(https://doi.org/10.1016/j.jhep.2015.10.020)
39.Zhou,C.,Vitiello,V.,Casals,E.,Puntes,V.,Iamunno,F.,Pellegrini,D.,Changwen,W.,Benvenuto,G.,Buttino,I.ToxicityofnickelinthemarinecalanoidcopepodAcartiatonsa:Nickelchlorideversusnanoparticles.AquaticToxicology170,1-12,(2016)(https://doi.org/10.1016/j.aquatox.2015.11.003)
2015年
38.Boyles,M.,Kristl,T.,Andosch,A.,Zimmermann,M.,Tran,N.,Casals,E.,Himly,M.,Puntes,V.,etal.Chitosanfunctionalisationofgoldnanoparticlesencouragesparticleuptakeandinducescytotoxicityandpro-inflammatoryconditionsinphagocyticcells,aswellasenhancingparticleinteractionswithserumcomponentsJournalofNanobiotechnology13:84(2015)(https://doi.org/10.1186/s12951-015-0146-9)
37.Stoehr,L.C.,Endes,C.,Radauer-Preiml,I.,Boyles,M.,Casals,E.,Balog,S.,Pesch,M.,etal.Assessmentofapanelofinterleukin-8reporterlungepithelialcelllinestomonitorthepro-inflammatoryresponsefollowingzincoxidenanoparticleexposureunderdifferentcellcultureconditionsParticleandFibreToxicology12(1),1(2015)(https://doi.org/10.1186/s12989-015-0104-6)
36.Contreras,A.R.,Casals,E.,Puntes,V.,Komilis,D.,Sanchez,A.,Font,X.Useofceriumoxidenanoparticlesfortheadsorptionofdissolvedcadmium(II),lead(II)andchromium(IV)attwodifferentpHsinasingleandmulti-componentsystemsGlobalNestJournal17(3),536-543,(2015).
35.Schlinkert,P.,Casals,E.,Boyles,M.,Tischler,U.,Hornig,E.,Tran,N.,Zhao,J.,Himly,M.,Riediker,M.,Oostingh,G.J.,Puntes,V.,Duschl,A.Theoxidativepotentialofdifferentlychargedsilverandgoldnanoparticlesonthreehumanlungepithelialcelltypes.JournalofNanobiotechnology13:1,(2015).https://doi.org/10.1186/s12951-014-0062-4IF:4,08
34.Li,Y.,Italiani,P.,Casals,E.,Tran,N.,Puntes,V.,Boraschi,D.OptimisingtheuseofcommercialLALassaysfortheanalysisofendotoxincontaminationinmetalcolloidsandmetaloxidenanoparticles.Nanotoxicology,9(4),462-473(2015).(https://doi.org/10.3109/17435390.2014.948090).
2014年
33.Verstraelen,S.,Remy,S.,Casals,E.,DeBoever,P.,Witters,H.,Gatti,A.,Puntes,V.,Nelissen,I.Geneexpressionprofilesrevealdistinctimmunologicalresponsesofcobaltandceriumdioxidenanoparticlesintwoinvitrolungepithelialcellmodels.Toxicologyletters228(3),157-169,(2014).
(https://doi.org/10.1016/j.toxlet.2014.05.006)
32.Casals,E.,Barrena,R.,García,A.,González,E.,Delgado,L.,Busquets‐Fité,M.,Font,X.,Arbiol,J.,Glatzel,P.,Kvashnina,K.,Sánchez,A.,Puntes,V.ProgrammedIronOxideNanoparticlesDisintegrationinAnaerobicDigestersBoostsBiogasProduction.Small10(14),2801-2808,(2014).
(https://doi.org/10.1002/smll.201303703)
31.Oró,D.,Fernández-Varo,G.,Yudina,T.,Casals,E.,Casals,G.,GonzálezdelaPresa,B.,Puntes,V.F.,Jiménez,W.HepatoprotectiveeffectofCeO2NanoparticlesinratstreatedwithCCl4.JournalofHepatology,60(1),S77(2014)
(https://doi.org/10.1016/S0168-8278(14)60196-3)
2013年
30.Cafun,J.D.,Kvashnina,K.O.,Casals,E.,Puntes,V.F.,Glatzel,P.AbsenceofCe3+SitesinChemicallyActiveColloidalCeriaNanoparticles,ACSnano7(12),10726-10732,(2013).
(https://doi.org/10.1021/nn403542p)
29.Ojea-Jimenez,I.,Comenge,J.,Garcia-Fernandez,L.,Megson,ZA.,Casals,E.,Puntes,VF.,EngineeredinorganicnanoparticlesfordrugdeliveryapplicationsCurrentdrugmetabolism14(5),518-530,(2013).
(https://doi.org/10.2174/13892002113149990008#sthash.UTteSa3H.dpuf)
28.Piella,J.,Bastús,N.G.,Casals,E.,Puntes,V.CharacterizingNanoparticlesReactivity:Structure-PhotocatalyticActivityRelationship.JournalofPhysics:ConferenceSeries429(1),012040(2013).
(https://doi.org/10.1088/1742-6596/429/1/012040)
2012年
27.Casals,E.,Puntes,V.Inorganicnanoparticlebiomolecularcorona:formation,evolutionandbiologicalimpact,Nanomedicine7(12),1917-1930(2012).
(https://doi.org/10.2217/nnm.12.169)
26.Casals,E.,Gonzalez,E.,Puntes,V.,Reactivityofinorganicnanoparticlesinbiologicalenvironments:insightsintonanotoxicitymechanisms.J.Phys.D:Appl.Phys.45443001(2012).(https://doi.org/10.1088/0022-3727/45/44/443001)
25.S.Goy-Lopez,J.Juarez,M.Alatorre-Meda,E.Casals,V.Puntes,P.TaboadaandV.Mosquera.PhysicochemicalCharacteristicsofProtein-NPBioconjugates:TheRoleofParticleCurvatureandSolutionConditionsonHumanSerumAlbuminConformationandFibrillogenesisInhibition.Langmuir28(24),9113-9126(2012).
(https://doi.org/10.1021/la300402w)
24.A.R.Contreras,A.Garcia,E.Gonzalez,E.Casals,V.Puntes,A.Sanchez,X.FontandS.Recillas.PotentialuseofCeO2,TiO2andFe3O4nanoparticlesfortheremovalofcadmiumfromwater.Desalin.WaterTreat.41(1-3),296-300(2012).
(https://doi.org/10.1080/19443994.2012.664743)
23.Recillas,A.Garcia,E.Gonzalez,E.Casals,V.Puntes,A.SanchezandX.Font.Preliminarystudyofphosphateadsorptionontoceriumoxidenanoparticlesforuseinwaterpurification;nanoparticlessynthesisandcharacterization.WaterSciTechnol66(3),503-509(2012).(https://doi.org/10.2166/wst.2012.185)
22.Garcia,A.,Delgado,L.,Tora,J.A.,Casals,E.,Gonzalez,E.,Puntes,V.,Font,X.,Carrera,J.,Sanchez,A.Effectofceriumdioxide,titaniumdioxide,silver,andgoldnanoparticlesontheactivityofmicrobialcommunitiesintendedinwastewatertreatment.JournalofHazardousMaterials199,64-72(2012).
(https://doi.org/10.1016/j.jhazmat.2011.10.057)
2011年
21.StoehrL.C.,GonzalezE.,StampflA.,CasalsE.,DuschlA.,PuntesV.,OostinghG.J.Shapematters:effectsofsilvernanospheresandwiresonhumanalveolarepithelialcells.ParticleandFibreToxicology8(1),36(2011).
(https://doi.org/10.1186/1743-8977-8-36)
20.CasalsE.,PfallerT.,DuschlA.,OostinghG.J.,PuntesV.F.HardeningoftheNanoparticle-ProteinCoronainMetal(Au,Ag)andOxide(Fe3O4,CoO,andCeO2)Nanoparticles.Small7(24),3479-3486(2011).
(https://doi.org/10.1002/smll.201101511)
19.RecillasS.,GarciaA.,GonzalezE.,CasalsE.,PuntesV.,SanchezA.,FontX.UseofCeO(2),TiO(2)andFe(3)O(4)nanoparticlesfortheremovalofleadfromwaterToxicityofnanoparticlesandderivedcompounds.Desalination277(1-3),213-220(2011).(https://doi.org/10.1016/j.desal.2011.04.036)
18.CandeloroP.,TirinatoL.,MalaraN.,FregolaA.,CasalsE.,PuntesV.,PerozzielloG.,GentileF.,ColuccioM.L.,DasG.,LiberaleC.,DeAngelisF.,DiFabrizioE.NanoparticlemicroinjectionandRamanspectroscopyastoolsfornanotoxicologystudies.Analyst136(21),4402-4408,(2011).(https://doi.org/10.1039/c1an15313g)
17.BoraschiD.,OostinghG.J.,CasalsE.,ItalianiP.,NelissenI.,PuntesV.,DuschlA.Nano-immunosafety:issuesinassayvalidation.JournalofPhysics:ConferenceSeries304012077,(2011).(https://doi.org/10.1088/1742-6596/304/1/012077)
16.SanchezA.,RecillasS.,FontX.,CasalsE.,GonzalezE.,PuntesV.Ecotoxicityof,andremediationwith,engineeredinorganicnanoparticlesintheenvironment.Trac-TrendsinAnalyticalChemistry30(3),507-516(2011).
(http://doi.org/10.1016/j.trac.2010.11.011)
15.GarciaA.,EspinosaR.,DelgadoL.,CasalsE.,GonzalezE.,PuntesV.,BarataC.,FontX.,SanchezA.Acutetoxicityofceriumoxide,titaniumoxideandironoxidenanoparticlesusingstandardizedtests.Desalination269(1-3),136-141(2011).
(https://doi.org/10.1016/j.desal.2010.10.052)
14.OostinghG.J.,CasalsE.,ItalianiP.,ColognatoR.,StritzingerR.,PontiJ.,PfallerT.,KohlY.,OomsD.,FavilliF.,LeppensH.,LucchesiD.,RossiF.,NelissenI.,ThieleckeH.,PuntesV.F.,DuschlA.,BoraschiD.Problemsandchallengesinthedevelopmentandvalidationofhumancell-basedassaystodeterminenanoparticle-inducedimmunomodulatoryeffects.Problemsandchallengesinthedevelopmentandvalidationofhumancell-basedassaystodeterminenanoparticle-inducedimmunomodulatoryeffects.ParticleandFibreToxicology8,(2011).
(https://doi.org/10.1186/1743-8977-8-8)
2010年
13.RecillasS.,ColonJ.,CasalsE.,GonzalezE.,PuntesV.,SanchezA.,FontX.ChromiumVIadsorptiononceriumoxidenanoparticlesandmorphologychangesduringtheprocess.JournalofHazardousMaterials184(1-3),425-431(2010).
(https://doi.org/10.1016/j.jhazmat.2010.08.052)
12.CasalsE.,PfallerT.,DuschlA.,OostinghG.J.,PuntesV.TimeEvolutionoftheNanoparticleProteinCorona.AcsNano4(7),3623-3632(2010).
(https://doi.org/10.1021/nn901372t)
11.PfallerT.,ColognatoR.,NelissenI.,FavilliF.,CasalsE.,OomsD.,LeppensH.,PontiJ.,StritzingerR.,PuntesV.,BoraschiD.,DuschlA.,OostinghG.J.Thesuitabilityofdifferentcellularinvitroimmunotoxicityandgenotoxicitymethodsfortheanalysisofnanoparticle-inducedevents.Nanotoxicology4(1),52-72(2010).
(https://doi.org/10.3109/17435390903374001)
10.PaulR.,BautistaL.,DeLaVargaM.,BotetJ.M.,CasalsE.,PuntesV.,MarsalF.Nano-cottonFabricswithHighUltravioletProtection.TextileResearchJournal80(5),454-462(2010).(https://doi.org/10.1177/0040517509342316)
9.LimS.I.,Ojea-JimenezI.,VaronM.,CasalsE.,ArbiolJ.,PuntesV.SynthesisofPlatinumCubes,Polypods,Cuboctahedrons,andRaspberriesAssistedbyCobaltNanocrystals.NanoLetters10(3),964-973(2010).
(https://doi.org/10.1021/nl100032c)
2009年
8.SperlingR.A.,CasalsE.,ComengeJ.,BastusN.G.,PuntesV.F.InorganicEngineeredNanoparticlesandTheirImpactontheImmuneResponse.CurrentDrugMetabolism10(8),895-904(2009).(https://doi.org/10.2174/138920009790274577)
7.NelissenI.,VerstraelenS.,DeBoeverP.,CasalsE.,OomsD.,LeppensH.,HollandersK.,VanDenHeuvelR.,SchoetersG.,PuntesV.,WittersH.Impactofengineerednanoparticlesonimmune-relatedgenesandprocessesinhumanalveolarepithelialcells.ToxicologyLetters189,S186-S186(2009).(https://doi.org/10.1016/j.toxlet.2009.06.649)
6.BarrenaR.,CasalsE.,ColonJ.,FontX.,SanchezA.,PuntesV.Evaluationoftheecotoxicityofmodelnanoparticles.Chemosphere75(7),850-857(2009).
(https://doi.org/10.1016/j.chemosphere.2009.01.078)
5.PfallerT.,PuntesV.,CasalsE.,DuschlA.,OostinghG.J.Invitroinvestigationofimmunomodulatoryeffectscausedbyengineeredinorganicnanoparticles-theimpactofexperimentaldesignandcellchoice.Nanotoxicology3(1),46-59(2009).
(https://doi.org/10.1080/17435390802546071)
2008年
4.BastusN.G.,CasalsE.,Vazquez-CamposS.,PuntesV.Reactivityofengineeredinorganicnanoparticlesandcarbonnanostructuresinbiologicalmedia.Nanotoxicology2(3),99-112(2008).(https://doi.org/10.1080/17435390802217830)
3.CasalsE.,BastusN.,Vazquez-CamposS.,VaronM.,ComengeJ.,PuntesV.InorganicNanoparticlesandBiology.ContributionstoScience4(2),171-176(2008).
(https://doi.org/10.2436/20.7010.01.47)
2.GuixM.,CarbonellC.,ComengeJ.,García-FernándezL.,AlarcónA.,CasalsE.,PuntesV.Nanoparticlesforcosmetics.Howsafeissafe?ContributionstoScience4(2),213-217(2008).(https://doi.org/10.2436/20.7010.01.52)
1.CasalsE.,Vazquez-CamposS.,BastusN.G.,PuntesV.Distributionandpotentialtoxicityofengineeredinorganicnanoparticlesandcarbonnanostructuresinbiologicalsystems.Trac-TrendsinAnalyticalChemistry27(8),672-683(2008).