研究领域

内源性免疫，包括树突状细胞的TLRs信号传导，细胞代谢，线粒体功能，氨基酸代谢，抗原加工，inflammasome（炎性体）的激活，细胞自噬

近期论文

L.Bao,O.Al-Assar,L.Drynan,M.Arends,P.Tyers,R.Barker,andT.Rabbitts.Anon-cellautonomousmousemodelofCNShaemangioblastomamediatedbymutantKRAS.ScientificReports.2017,21;7:44899.

2.L.Bao,C.Hannon,A.Cruz-Migoni,D.Ptchelkine,M.Sun,.Miller,W.Bunjobpol,CE.Quevedo,M.Derveni,J.Chambers,T.Rabbits.IntracellularimmunizationagainstHIVinfectionwithanintracellularantibodythatmimicsHIVintegrasebindingtothecellularLEDGFprotein.ScientificReports.2017,7:16869.doi:10.1038/s41598-017-16742-2

3.KParikh,AAntanaviciute,DFawkner-Corbett,MJagielowicz,JKinchen,AAulicino,NAshley,EJohnson,PHublitz,LBao,JLukomska,RSinghAndev,EBjorkland,HKoohy,ASimmons.Single-cellcensusofthecolonicepitheliumrevealsgobletcelldriversofbarrierbreakdownininflammatoryboweldisease.Nature(inreview).

4.XiangY,LiaoXH*,YaoA,QinH,FanLJ,LiJP,HuP,LiH,GuoW,LiJY,GuCJ,BaoLY*,ZhangTC*.MRTF-A-miR-206-WDR1formfeedbacklooptoregulatebreastcancercellmigration.ExpCellRes.2017Oct15;359(2):394-404

5.LiaoXH,XiangY,LiH,ZhengL,XuY,XiYuC,LiJP,ZhangXY,XingWB,CaoDS,BaoLY,ZhangTC.VEGF-AStimulatesSTAT3ActivityviaNitrosylationofMyocardintoRegulatetheExpressionofVascularSmoothMuscleCellDifferentiationMarkers.SciRep.2017Jun1;7(1):2660.

6.LiH,XiangY,FanLJ,ZhangXY,LiJP,YuCX,BaoLY,CaoDS,XingWB,LiaoXH,ZhangTC.Myocardininhibitedthegapproteinconnexin43viapromotedmiR-206toregulatevascularsmoothmusclecellphenotypicswitch.Gene.2017Mar22.pii:S0378-1119(17)30198-1.

7.LiaoXH,WangN,ZhaoDW,ZhengDL,ZhengL,XingWJ,MaWJ,BaoLY,DongJ,ZhangTC.STAT3ProteinRegulatesVascularSmoothMuscleCellPhenotypicSwitchbyInteractionwithMyocardin.JBiolChem.2015Aug7;290(32):19641-52.

8.CahillTJ,LeoV,KellyM,StockenhuberA,KennedyNW,BaoL,CereghettiG,HarperAR,CzibikG,LaoC,BellahceneM,SteeplesV,GhaffariS,YavariA,MayerA,PoultonJ,FergusonDJ,ScorranoL,HettiarachchiNT,PeersC,BoyleJ,HillRB,SimmonsA,WatkinsH1,DearTN,AshrafianH.ResistanceofDynamin-relatedprotein1OligomerstoDisassemblyImpairsMitophagyResultinginMyocardialInflammationandHeartfailure.JBiolChem.2015Oct23;290(43):25907-19.

9.BaoL,OdellAF,StephenSL,WheatcroftSB,WalkerJH,PonnambalamS.CalciumbindingproteinS100A6regulateendothelialcellproliferationandsenescence.FEBSJournal.2012Oct25.doi:10.1111/febs.12044.

10.BrunsAF,YuldashevaN,LathamAM,BaoL,Pellet-ManyC,FrankelP,StephenSL,HowellGJ,WheatcroftSB,KearneyMT,ZacharyIC,PonnambalamS.AHeat-ShockProteinAxisRegulatesVEGFR2Proteolysis,BloodVesselDevelopmentandRepair.PLOSONE.2012,7(11),e48539.

11.BrunsAF,BaoL,WalkerJH,PonnambalamS(2009)Co-ordinationoftheVEGF-A-stimulatedresponseinendothelialcellsviaVEGFR1andVEGFR2traffickingandproteolysis.Biochem.Soc.Trans.37:1193-1197.

12.BaoL,RedondoC,FindlayJBC,WalkerJH,PonnambalamS(2009)Decipheringsolubleandmembraneproteininteractionsusingyeastsystems.Mol.Membr.Biol.26:127-135.

13.LuR,JiaJ,BaoL,FuZ,LiG,WangS,WangZ,JinM,GaoW,YaoZ.(2006)ExperimentalstudyoftheinhibitionofhumanhepatocarcinomaBel7402cellsbythetripeptidetyroserleutide(YSL).CancerChemotherPharmacol.57:248-256.

14.WangY,YangJ,GaoY,DuYR,BaoLY,NiuWY,YaoZ.(2006)Regulatoryeffectofe2,IL-6andIL-8onthegrowthofepithelialovariancancercells.CellMolImmunol.2:365-372.

15.包乐媛，张业尼，钱磊，等.大豆肽对高血脂症大鼠的降脂作用[J].大豆科学，2007，26(5):752-756.

16.包乐媛,李会强,毕晓阳,李国立，姚智.人滑膜细胞的分离培养与鉴定.中国医学检验杂志2004,5(5):386-388.

17.包乐媛,陆融,李国立,王松,付正,贾静,高文远,赵琳,姚智.四肽化合物CMST1对大鼠佐剂性关节治疗作用的实验研究.中国药理学通报,2005,21(9):1148-1149.

18.樊欣迎,包乐媛,朱婧,刘翊,杜连祥.表皮生长因子受体干扰序列与白细胞介素24融合蛋白的原核表达[J].生物技术通讯.2009(01);

19.樊欣迎,包乐媛,窦苓,杜连祥,路福平.融合蛋白EGFRi-IL-24的纯化及活性鉴定[J].药物生物技术.2009(04)

20.钱磊,包乐媛,鄂旭,路福平,杜连祥.脱脂豆粕酶法制备大豆肽[J].化学与生物工程.2007(03)

21.王建玲,樊欣迎,包乐媛,杜连祥.融合基因EGFRi-IL-24真核表达载体的构建与表达[J].生物医学工程学杂志.2010(02)

22.李岩,李会强,许瀛海,张静楷,包乐媛,姚智.糖尿病视网膜病变血清IgG型抗内皮细胞抗体检测.天津医药，2006,34(3):151-153.

23.包乐媛,李会强.细胞因子检测试剂盒简介.吕世静主编.临床免疫学检验实验指导.北京:中国医药科技出版社.2005:79-81.