个人简历

学习经历： 2017.9---现在，波士顿大学，化学系，访问学者 2010.6---2011.12，伊利诺伊大学香槟校区（UIUC）基因组生物研究所，博士后 2008.6---2010.5，上海交通大学，生命科学学院，博士后 2001.9---2007.12，华中农业大学，生命科学技术学院，博士 1997.9---2001.7， 华中农业大学，生命科学技术学院，本科 工作经历： 2012.1---现在，武汉大学药学院

研究领域

微生物来源的含磷天然产物的发掘与生物合成研究

近期论文

1. Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C*. Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production. Synth Syst Biotechnol. 2019 Ma;4(1):34-39. doi: 10.1016/j.synbio.2018.12.003 2. Chen L#, Naowarojna N#, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C*, and Liu P*. Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr). ACS Catal. 2019, 9(1): 253-258. doi: 10.1021/acscatal.8b03903 3. Naowarojna N#, Cheng R#, Chen L#, Quill M, Xu M, Zhao C*, Liu P*. Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis. Biochemistry. 2018 Jun 19;57(24):3309-3325. doi: 10.1021/acs.biochem.8b00239. 4. Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C*, Liu P*. Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation. J Am Chem Soc. 2018 Apr 4;140(13):4604-4612. doi: 10.1021/jacs.7b13628. 5. Deng Q, Zhou L, Luo M, Deng Z, Zhao C*. Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers. Synth Syst Biotechnol. 2017 Mar 24;2(1):59-64. doi: 10.1016/j.synbio.2017.03.001. 6. Li M, Chen L, Deng Z, Zhao C*. Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins. FEBS Open Bio. 2016 May 16;6(6):603-9. doi: 10.1002/2211-5463.12071. 7. Chen L, Li P, Deng Z, Zhao C*. Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola. Sci Rep. 2015 Aug 10;5:12892. doi: 10.1038/srep12892. 8. Hao C#, Huang S#, Deng Z, Zhao C*, Yu Y*. Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent \