个人简历

主要教育和工作经历： 1991-1995 武汉大学生命科学学院学士 1995-1998 武汉大学生命科学学院硕士 1998-2000 中国医学科学院基础医学研究所博士 2004-2005 Georgetown University 博士后 2000-2004 中国医学科学院基础医学研究所助理研究员，副研究员 2005-2008 Case Western Reserve University 研究助理 2008-至今 武汉大学生命科学学院教授

研究领域

本实验室以体细胞、斑马鱼、小鼠和大鼠基因敲除/敲入技术为主要研究方法，从分子水平探讨肿瘤的发病机理, 研究相关基因作用途径和寻找理想的分子靶标，为肿瘤的早期诊断、治疗和预后提供理论依据。

近期论文

[1] X.F. Zhang, K.K. Li, L. Gao, S.Z. Li, K. Chen, J.B. Zhang, D. Wang, R.F. Tu, J.X. Zhang, K.X. Tao, G. Wang, X.D. Zhang, miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta, Oncotarget, 6 (2015) 4144-4158. [2] Z.Y. Zhang, S.Z. Li, H.H. Zhang, Q.R. Wu, J. Gong, T. Liang, L. Gao, N.N. Xing, W.B. Liu, R.L. Du, X.D. Zhang, Stabilization of ATF5 by TAK1-NLK Critically Regulates the IL-1beta-stimulated C/EBP Signaling Pathway, Mol Cell Biol, (2014). [3] X.F. Zhang, R. Zhang, L. Huang, P.X. Wang, Y. Zhang, D.S. Jiang, L.H. Zhu, S. Tian, X.D. Zhang, H. Li, TRAF1 is a key mediator for hepatic ischemia/reperfusion injury, Cell death & disease, 5 (2014) e1467. [4] H.H. Zhang, S.Z. Li, Z.Y. Zhang, X.M. Hu, P.N. Hou, L. Gao, R.L. Du, X.D. Zhang, Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage, Cell death and differentiation, 21 (2014) 1656-1663. [5] L. Yan, W. Liu, H. Zhang, C. Liu, Y. Shang, Y. Ye, X. Zhang, W. Li, Ube2g2-gp78-mediated HERP polyubiquitylation is involved in ER stress recovery, Journal of cell science, 127 (2014) 1417-1427. [6] S.Z. Li, H.H. Zhang, J.B. Liang, Y. Song, B.X. Jin, N.N. Xing, G.C. Fan, R.L. Du, X.D. Zhang, Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKbeta, Biochimica et biophysica acta, (2014). [7] S.-Z. Li, Y. Song, H.-H. Zhang, B.-X. Jin, Y. Liu, W.-B. Liu, X.-D. Zhang, R.-L. Du, UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer, Sci. Rep., 4 (2014). [8] X.A. Wang, R. Zhang, Z.G. She, X.F. Zhang, D.S. Jiang, T. Wang, L. Gao, W. Deng, S.M. Zhang, L.H. Zhu, S. Guo, K. Chen, X.D. Zhang, D.P. Liu, H. Li, Interferon regulatory factor 3 constrains IKKbeta/NF-kappaB signaling to alleviate hepatic steatosis and insulin resistance, Hepatology, (2013). [9] L. Wang, Y. Lu, X. Zhang, Y. Zhang, D. Jiang, X. Dong, S. Deng, L. Yang, Y. Guan, L. Zhu, Y. Zhou, X. Zhang, H. Li, Mindin is a critical mediator of ischemic brain injury in an experimental stroke model, Experimental neurology, 247 (2013) 506-516. [10] S.Z. Li, H.H. Zhang, J.N. Zhang, Z.Y. Zhang, X.F. Zhang, X.D. Zhang, R.L. Du, ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis, Biochemical and biophysical research communications, 437 (2013) 325-330. [11] D.S. Jiang, X.F. Zhang, L. Gao, J. Zong, H. Zhou, Y. Liu, Y. Zhang, Z.Y. Bian, L.H. Zhu, G.C. Fan, X.D. Zhang, H. Li, Signal Regulatory Protein-alpha Protects Against Cardiac Hypertrophy Via the Disruption of Toll-Like Receptor 4 Signaling, Hypertension, (2013). [12] Z. Huang, S. Li, W. Song, X. Li, Q. Li, Z. Zhang, Y. Han, X. Zhang, S. Miao, R. Du, L. Wang, Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/Beta-catenin pathway by down-regulating Dickkopf-1 (DKK1), PloS one, 8 (2013) e70077. [13] K. Chen, L. Gao, Y. Liu, Y. Zhang, D.-S. Jiang, X. Wei, X. Zhu, R. Zhang, Y. Chen, Q. Yang, N. Kioka, X.-D. Zhang, H. Li, Vinexin-β protects against cardiac hypertrophy by blocking the Akt-dependent signalling pathway, Basic research in cardiology, 108 (2013) 1-14. [14] Y. Liu, S. Li, H. Zhang, Z. Wan, X. Zhang, R. Du, A one-step cloning method for the construction of somatic cell gene targeting vectors: application to production of human knockout cell lines, BMC biotechnology, 12 (2012) 71. [15] P. Zhang, Y. Zhao, X. Zhu, D. Sedwick, X. Zhang, Z. Wang, Cross-talk between phospho-STAT3 and PLCgamma1 plays a critical role in colorectal tumorigenesis, Molecular cancer research : MCR, 9 (2011) 1418-1428. [16] R. Du, S. Li, X. Zhang, A modified plasmid vector pCMV-3Tag-LIC for rapid, reliable, ligation-independent cloning of polymerase chain reaction products, Analytical biochemistry, 408 (2011) 357-359. [17] P. Wang, F. Zou, X. Zhang, H. Li, A. Dulak, R.J. Tomko, Jr., J.S. Lazo, Z. Wang, L. Zhang, J. Yu, microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells, Cancer research, 69 (2009) 8157-8165. [18] X. Zhang, C. Guo, Y. Chen, H.P. Shulha, M.P. Schnetz, T. LaFramboise, C.F. Bartels, S. Markowitz, Z. Weng, P.C. Scacheri, Z. Wang, Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies, Nature methods, 5 (2008) 163-165. [19] C. Guo, X. Zhang, S.P. Fink, P. Platzer, K. Wilson, J.K. Willson, Z. Wang, S.D. Markowitz, Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase, Cancer research, 68 (2008) 6118-6126. [20] X. Zhang, A. Guo, J. Yu, A. Possemato, Y. Chen, W. Zheng, R.D. Polakiewicz, K.W. Kinzler, B. Vogelstein, V.E. Velculescu, Z.J. Wang, Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T, Proceedings of the National Academy of Sciences of the United States of America, 104 (2007) 4060-4064.