个人简历

受教育经历（从大学本科开始，按时间倒排序） 1986/09-1989/07 武汉大学，化学系，学士﹑硕士 1992/12-1996/05 香港中文大学,化学系，博士 研究工作经历（按时间倒排序） 1989/07-/1992/12， 武汉大学，化学系,助教,讲师 1996/10-1998/10， 美国弗吉利亚大学,化学系,博士后， 从事小分子与核酸的识别和相互作用 1998/11-2001/05， 美国马里兰大学,化学与生物化学系，博士后，从事小分子与核酸的识别和相互作用 2001/05-至今， 武汉大学，化学与分子科学学院，教授，博士生导师 2009/10-2012/10， 教育部长江学者特聘教授

研究领域

化学生物学、生物有机化学、药物化学。

近期论文

1.Wang, S. R., Fu, B. S., Wang, J. Q., Wang, Long, Y. L., Zhang, X. E., Peng, S., Guo, P., Tian, T.* and Zhou, X.* Novel Amplex Red Oxidases based on Non-canonical DNA Structures: Property Studies and Applications in MicroRNA Detection. Anal. Chem., 2014, DOI: 10.1021/ac402535a. 2.Wang, C., Feng, S., Wu, L., Yan, S., Zhong, C., Guo, P., Huang, R., Weng, X.* and Zhou, X.* A new fluorescent turn-on probe for highly sensitive and selective detection of sulfite and bisulfite. Sens. Actuators B Chem., 2014, 190, 792-799. 3.Wang, S., Long, Y., Wang, J., Ge, Y., Guo, P., Liu, Y., Tian, T.* and Zhou, X.* Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: The effects on the B-Z transition. J. Am. Chem. Soc., 2014. 136. 56-59. 4.Tang, Y., Chu, J.-M., Huang, W., Xiong, J., Xing, X.-W., Zhou, X., Feng, Y.-Q.* and Yuan, B.-F*. Hydrophilic Material for the Selective Enrichment of 5-hydroxymethylcytosine and Its LC-MS/MS Detection. Anal. Chem., 2013, 85, 6129−6135. 5.Hong, T., Wang, T., Guo, P., Xing, X., Ding, F., Chen, Y., Wu, J., Ma, J., Wu, F. and Zhou, X.* Fluorescent Strategy Based on Cationic Conjugated Polymer Fluorescence Resonance Energy Transfer for the Quantification of 5-(Hydroxymethyl) cytosine in Genomic DNA. Anal. Chem., 2013, 85, 10797-10802. 6.Wang, C., Yan, S., Huang R., Feng S., Fu, B., Weng, X.* and Zhou, X.* A turn-on fluorescent probe for detection of tyrosinase activity. Analyst, 2013,138, 2825-2828 7.Guo, P., Yan, S., Zhou, Y., Wang C., Xu, X., Weng, X., and Zhou, X.* A novel fluorescent “Turn-Off/Turn-On” system for the detection of acid phosphatase activity. Analyst, 2013, 138, 3365-3367. 8.Tian, T., Zhang, X., Fu, B., Long, Y., Peng, S., Wang, S.*, and Zhou, X*. Systematic investigation of DNAs with modified cytosines under hot alkali treatment. ChemComm, 2013, 49, 9968-9970. 9.Tian, T., Peng, S., Xiao, H., Long, Y., Fu, B., Zhang, X., Guo, S., Wang, S.*, Zhou, X.* and Liu, S. 5-Methyldeoxycytidine enhances the substrate activity of DNA polymerase. ChemComm, 2013, 49, 10085-10087. 10. Wang, S., Fu, B., Peng, S., Zhang, X., Tian, T. * and Zhou, X.* The G-triplex DNA could function as a new variety of DNA peroxidase. ChemComm, 2013, 49, 7920-7922. 11. Hu, J., Xing, X., Xu, X., Wu, F., Guo, P., Yan, S., Xu, Z., Xu, J., Weng, X. and Zhou, X.* Selective Chemical Labelling of 5-Formylcytosine in DNA by Fluorescent Dyes. Chem. Eur. J., 2013, 19, 5836-5840. 12. Tian, T., Xiao, H., Zhang, Z., Long, Y., Peng, S., Wang, S.*, Zhou, X., Liu, S. and Zhou, X.*. Sensitive and Convenient Detection of microRNAs Based on Cascade Amplification by Catalytic DNAzymes.Chem. Eur. J.,2013, 19, 92-95. 13. Du, Y.* and Zhou, X.* Targeting Non‐B‐Form DNA in Living Cells. Chem. Rec., 2013, 13, 371-384. 14. Liu, L., Zhai, Q., Hong, T., Ge, Y., Hu, P., Weng, X.*, Liu, Y. and Zhou, X.* Selective cleavage of DNA at guanosine bases which locate in DNA non-duplex portions within duplexes by ruthenium (II) complexes. Inorg. Chim. Acta, 2013, 394, 385–390. 15. Wang, T., Hong, T., Tang, T., Zhai, Q., Xing, X., Mao, W., Zheng, X., Xu, L.; Wu, J., Weng, X., Wang, S., Tian, T., Yuan, B., Huang, B., Zhuang,L; Zhou, X.* Application of N-Halogeno-N- sodiobenzene sulfonamide Reagents to the Selective Detection of 5-Methylcytosine in DNA Sequences. J. Am. Chem. Soc., 2013, 135, 1240-1243. 16. Yuan, L., Tian, T., Chen, Y., Zhang, Z. and Zhou, X*. An L-DNA G-Quadruplex: Application for Peroxidase DNAzyme. Nucleos. Nucleot. Nucl., 2013, 32, 589-598. 17. Wu, J., Huang, R., Wang, C., Liu, W., Wang, J., Weng, X., Tian, T. and Zhou, X.*. Thiol-inducible direct fluorescence monitoring of drug release. Org. Biomol. Chem., 2013, 11, 580-585. 18. Wu, J., Huang, R., Wang, T., Zhao, X., Zhang, W., Weng, X., Tian, T., Zhou, X.* Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug. Org. Biomol. Chem. 2013, 11, 2365-2369. 19. Guo, P., Xu, X., Qiu, X., Zhou, Y., Yan, S., Wang, C., Lu, C., Ma, W., Weng, X. and Zhou, X*. Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2′-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives. Org. Biomol. Chem., 2013, 11, 1610-1613. 20. Mao, W., Hu, J., Hong, T., Xing, X., Wang, S., Chen, X., Zhou, X.* A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences. Org. Biomol. Chem. 2013, 11, 3568-3572.