个人简历

1997.9-2001.6 武汉大学生命科学学院 生物化学专业 学士\r
2001.9-2006.6 武汉大学生命科学学院 生物物理专业 博士\r
2006.11-2007.6 新加坡国立大学生物系 博士后\r
2007.7-2010.12 美国加州大学河滨分校化学系 博士后\r
2011.1 至今 武汉大学化学与分子科学学院 教授/博导\r
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袁必锋:博士，武汉大学化学与分子科学学院教授、博士生导师，国家自然科学基金优秀青年基金获得者（2015年）。2001年和2006年于武汉大学生命科学学院分别获得学士和博士学位。2006年至2010年在新加坡国立大学和加州大学河滨分校开展博士后研究。2011年任武汉大学化学与分子科学学院教授、博士生导师。担任Chinese Chemical Letters副主编、Chemical Research in Toxicology顾问编委(Editorial Advisory Board)、Scientific Reports编委、《色谱》编委、《分析测试学报》青年编委、《高等学校化学学报》青年编委、中国生物物理学会代谢组学分会理事。主要研究方向为生物分析化学、核酸化学生物学。在所从事的研究工作中，建立了DNA、RNA、蛋白质等多种生物大分子修饰（表观遗传修饰）的高灵敏分析方法，开展了生物大分子修饰和疾病的相关性研究；建立了多种代谢组学分析方法，开展了基于代谢组的临床疾病标志物分析。在PNAS、Nucleic Acids Research、Chemical Science等学术刊物上发表了190余篇SCI收录论文，专著一部，论文引用七千余次。

研究领域

"""""1. 核酸表观遗传修饰\r
核酸表观遗传修饰不仅在基因调控等方面有重要作用，而且在癌症等许多疾病的发生中也扮演着重要角色。本课题组通过建立质谱分析和测序等研究方法，对核酸表观遗传修饰的生理功能进行研究。\r
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2. 代谢组学\r
发展基于质谱技术的代谢组学研究方法，结合相应的生物学手段，探索代谢物在疾病发生、发展过程中的生理功能。\r
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3. 核酸损伤和修复\r
发展核酸损伤的检测手段，探索核酸损伤的定位、复制、转录、修复机制。"

近期论文

Ma, C.J., Li, L., Shao, W.X., Ding, J.H., Cai, X., Lun, Z., Yuan, B.F.* and Feng, Y.Q. (2021) An enzyme-mediated bioorthogonal labeling method for genome-wide mapping of 5-hydroxymethyluracil. Chem Sci, 12, 14126-14132.\r
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Feng, Y., Chen, J.J., Xie, N.B., Ding, J.H., You, X.J., Tao, W.B., Zhang, X., Yi, C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2021) Direct decarboxylation of Ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation. Chem Sci, 12, 11322-11329.\r
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Cheng, M.Y., You, X.J., Ding, J.H., Dai, Y., Chen, M.Y., Yuan, B.F.* and Feng, Y.Q. (2021) Novel dual methylation of cytidines in RNA of mammals. Chem Sci, 12, 8149–8156.\r
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Dai, Y., Yuan, B.F.* and Feng, Y.Q. (2021) Quantification and mapping of DNA modifications. RSC Chem Biol, 2, 1096–1114.\r
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Dai, Y., Qi, C.B., Feng, Y., Cheng, Q.Y., Liu, F.L., Cheng, M.Y., Yuan, B.F.* and Feng, Y.Q. (2021) Sensitive and Simultaneous Determination of Uridine Thiolation and Hydroxylation Modifications in Eukaryotic RNA by Derivatization Coupled with Mass Spectrometry Analysis. Anal Chem. 93, 6938-6946.\r
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Liu, F.L., Ye, T.T., Ding, J.H., Yin, X.M., Yang, X.K., Huang, W.H., Yuan, B.F.* and Feng, Y.Q. (2021) Chemical Tagging Assisted Mass Spectrometry Analysis Enables Sensitive Determination of Phosphorylated Compounds in a Single Cell. Anal Chem, 93, 6848-6856.\r
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Feng, Y., Xie, N.B., Tao, W.B., Ding, J.H., You, X.J., Ma, C.J., Zhang, X., Yi, C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2020) Transformation of 5-Carboxylcytosine to Cytosine Through C–C Bond Cleavage in Human Cells Constitutes a Novel Pathway for DNA Demethylation. CCS Chem, 2, 994-1008.\r
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Cheng, Q.Y., Xiong, J., Ma, C.J., Dai, Y., Ding, J.H., Liu, F.L., Yuan, B.F.* and Feng, Y. Q. (2020) Chemical tagging for sensitive determination of uridine modifications in RNA, Chem Sci, 11, 1878-1891.\r
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Ding, J.H., Ma, C.J., Chen, M.Y., Chen, B., Yuan, B.F.* and Feng, Y.Q. (2020) Quantification and single-base resolution analysis of N1-methyladenosine in mRNA by ligation-assisted differentiation. Anal Chem, 92, 2612-2619.\r
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Liu, F.L, Qi, C.B., Cheng, Q.Y., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2020) Diazo reagent labeling with mass spectrometry analysis for sensitive determination of ribonucleotides in living organisms. Anal Chem, 92, 2301-2309.\r
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You, X.J., Liu, T., Ma, C.J., Qi, C.B., Tong, Y., Zhao, X., Yuan, B.F.* and Feng, Y.Q. (2019) Determination of RNA hydroxylmethylation in mammals by mass spectrometry analysis. Anal Chem, 91, 10477-10483.\r
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Tang, F., Liu, S., Li, Q.Y., Yuan, J., Li, L., Wang, Y., Yuan, B.F.* and Feng, Y.Q. (2019) Location analysis of 8-oxo-7,8-dihydroguanine in DNA by polymerase-mediated differential coding. Chem Sci, 10, 4272–4281.\r
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Xiong, J., Ye, T.T., Ma, C.J., Cheng, Q.Y., Yuan, B.F.* and Feng, Y.Q. (2019) N6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals. Nucleic Acids Res, 47, 1268-1277.\r
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Chen, B., Yuan, B.F.* and Feng, Y.Q. (2019) Analytical Methods for Deciphering RNA Modifications. Anal Chem, 91, 743-756.\r
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Xu, J., Zhang, Q.F., Zheng, J., Yuan, B.F.* and Feng, Y.Q.* (2019) Mass spectrometry-based fecal metabolome analysis. TrAC-Trend Anal Chem, 112, 161-174.\r
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Ma, C.J., Ding, J.H., Ye, T.T., Yuan, B.F.* and Feng, Y.Q. (2019) AlkB Homologue 1 Demethylates N(3)-Methylcytidine in mRNA of Mammals. ACS Chem Biol, 14, 1418-1425.\r
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Li, Q.Y., Xie, N.B., Xiong, J., Yuan, B.F.* and Feng, Y.Q. (2018) Single-Nucleotide Resolution Analysis of 5-Hydroxymethylcytosine in DNA by Enzyme-Mediated Deamination in Combination with Sequencing. Anal Chem, 90, 14622-14628.\r
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Chu, J.M., Ye, T.T., Ma, C.J., Lan, M.D., Liu, T., Yuan, B.F.* and Feng, Y.Q. (2018) Existence of Internal N7-Methylguanosine Modification in mRNA Determined by Differential Enzyme Treatment Coupled with Mass Spectrometry Analysis. ACS Chem Biol. 13, 3243−3250\r
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Jiang, H.P., Xiong, J., Liu, F.L., Ma, C.J., Tang, X.L., Yuan, B.F.* and Feng, Y.Q. (2018) Modified nucleoside triphosphates exist in mammals. Chem Sci, 9, 4160-4167.\r
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Yuan, B.F., Zhu, Q.F., Guo, N., Zheng, S.J., Wang, Y.L., Wang, J., Xu, J., Liu, S.J., He, K., Hu, T., Zheng, Y.W., Xu, F.Q. and Feng, Y.Q.* (2018) Comprehensive Profiling of Fecal Metabolome of Mice by Integrated Chemical Isotope Labeling-Mass Spectrometry Analysis. Anal Chem, 90, 3512-3520.