个人简历

学习经历： 1998.9-2001.7 武汉大学内科学博士 1987.9-1990.7 湖北医科大学病原生物学硕士 1982.9-1987.7 湖北医科大学临床医学系本科学士 主要工作经历与任职： 2007.1 - 至今 武汉大学基础医学院药理学系教授、博导、系副主任 2002.11- 2006.12 武汉大学医学院药理学系副教授、硕导、系副主任 2006.9-2006.12 日本福岛医科大学药理学系研修 1990.9-1998.8 湖北省老年医学研究所临床药理研究室医师、主治医师

研究领域

⑴细胞膜重要脂质代谢产物功能研究：已知花生四烯酸被环氧化酶（COX）、脂氧酶（LOX）和细胞色素P450(CYP)酶代谢生成上百种结构相似，但具有不同生物活性的代谢产物，在生命活动和多种重大疾病过程中发挥重要的作用。然而，许多重要花生四烯酸代谢产物的作用机制和关键作用靶点等尚不清楚。本研究主要从事细胞膜重要脂质代谢产物调控肿瘤血管生成和转移等作用的研究，将为探索新靶标、新抗癌药物以及肿瘤防治提供新思路。

近期论文

1.Chen XW, Yu TJ, Zhang J, Li Y, Chen HL, Yang GF, Yu W, Liu YZ, Liu XX, Duan CF, Tang HL, Qiu M, Wang CL, Zheng H, Yue J, Guo AM, Yang J*. CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis. Oncogene. 2017, 36(35):5045-5057 2. Wang C, Li Y, Chen H, Zhang J, Zhang J, Qin T, Duan C, Chen X, Liu Y, Zhou X, Yang J*. Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma. Cancer Lett. 2017,402: 131-141. 3. Chen L, Ackerman R, Saleh M, Gotlinger KH, Kessler M, Mendelowitz LG, Falck JR, Arbab AS, Scicli AG, Schwartzman ML, Yang J*, Guo AM*. 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo. J Pharmacol Exp Ther. 2014,348: 442-51. 4. Zhao H, Zhang X, Chen X, Li Y, Ke Z, Tang T, Chai H, Guo AM, Chen H*, Yang J*. Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. Toxicol Appl Pharmacol. 2014, 279:311-321. 5. Zheng H, Li Y, Wang Y, Zhao H, Zhang J, Chai H, Tang T, Yue J, Guo AM*, Yang J*. Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. Toxicol Appl Pharmacol. 2014,280:10-20. 6. Li Y, Zhao H, Wang Y, Zheng H, Yu W, Chai H, Zhang J, Falck JR, Guo AM, Yue J, Peng R, Yang J*. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013,272, 37-48. 7. Yu W, Chai H, Li Y, Zhao H, Xie X, Zheng H, Wang C, Wang X, Yang G, Cai X, Falck JR, Yang J*. Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. Toxicol Appl Pharmacol. 2012,264, 73-83. 8. Zhao H, Li Y, Wang Y, Zhang J, Ouyang X, Peng R, Yang J*. Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice. Food Chem Toxicol. 2012,50, 2648-55. 9. Yu W, Chen L, Yang YQ, Falck JR, Guo AM, Li Y, Yang J*. Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemother Pharmacol. 2011, 68, 619-629. 10. Zhan C, Yang J*. Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Pharmacol Res. 2006; 53(3):303-9.