个人简历

学习经历： 1998.09 – 2001.06 武汉大学医学院，内科学，博士 1988.09－1991.06 湖北医科大学，病理生理学，硕士 1983.09－1988.06 湖北医科大学，临床医学，学士 主要工作经历与任职： 2001.06~至今 武汉大学基础医学院，副教授、教授，教研室副主任、主任 2014.01 – 2015.08 The University of South Dakota Sanford Medical College，Assistant Professor Research 2010.10 – 2011.09 The University of South Dakota Sanford Medical College，Visiting Research Scientist 2004.07 – 2008.09 University of Texas Health Science Center at San Antonio，Research Scientist 2003.04 – 2003.08 Henri Poincare Université, Nancy 1, Visiting Associate Professor 1993.01 – 1998.08 长江大学医学院，副教授 1991.07 – 1992.12 荆州市第一人民医院，主治医师

研究领域

研究重点集中在阐明代谢性疾病发生、发展的分子机制。率先揭示了脂联素 (adiponectin) 信号转导、及其胰岛素增敏效应的分子机制

近期论文

1. Li M, Zhang Y, Cao Y, Zhang D, Liu L, Guo Y, Wang C*. Icariin ameliorates palmitate-induced insulin resistance through reducing thioredoxin-interacting protein (TXNIP) and suppressing ER stress in C2C12 myotubes. Front. Pharmacol. 2018; 9:1180. 2. Ye M, Qiu H, Cao Y, Zhang M, Mi Y, Yu J, Wang C*. Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum. Front Pharmacol. 2017;8:148. 3. Jiang P, Zhang D, Qiu H, Yi X, Zhang Y, Cao Y, Zhao B, Xia Z, Wang C*. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017;44(7):760-770. 4. Ding Y, Zhang D, Wang B, Zhang Y, Wang L, Chen X, Li M, Tang Z, Wang C*. APPL1-mediated activation of STAT3 contributes to inhibitory effect of adiponectin on hepatic gluconeogenesis. Mol Cell Endocrinol. 2016;433:12-19. 5. Zhang D, Zhang Y, Ye M, Ding Y, Tang Z, Li M, Zhou Y, Wang C*. Interference with Akt signaling pathway contributes curcumin-induced adipocyte insulin resistance. Mol Cell Endocrinol. 2016;429:1-9. 6. Khan S, Zhang D, Zhang Y, Li M, Wang C*. Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties. Mol Cell Endocrinol. 2016;428:101-108. 7. Guan F, Ding Y, Zhang Y, Zhou Y, Li M, Wang C*. Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation. PLoS One. 2016;11(1):e0146553. 8. Wang C, Wang X. The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity. Biochim Biophys Acta. 2015;1852(2):188-194. 9. Zhang Y, Ye M, Chen LJ, Li M, Tang Z, Wang C*. Role of the ubiquitin-proteasome system and autophagy in regulation of insulin sensitivity in serum-starved 3T3-L1 adipocytes. Endocr J. 2015;62(8):673-686. 10. Zhang YM, Li MX, Tang Z, Wang CH*. Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. Acta Pharmacol Sin. 2015;36(8):987-997.