个人简历

学习经历： 1983.09~1988.06 武汉大学医学院（原湖北医学院），攻读学士学位 1996.09~1998.06 武汉大学医学院（原湖北医科大学），攻读硕士学位 2002.09~2006.06 武汉大学，攻读博士学位 2008.09~2010.12 美国南加州大学，访问学者、博士后 2016.09~2016.10 美国芝加哥大学，交流学习 主要工作经历与任职： 1988.07~1994.02 武汉市第九医院，住院医师 1994.03~1999.10 武汉大学组织学与胚胎学教研室，助教、讲师 1999.11~2010.10 武汉大学组织学与胚胎学教研室，副教授 2011.11~至今 武汉大学组织学与胚胎学教研室，教授、博导

研究领域

1）生殖生物学: 主要关注胚胎植入的分子机制以及不良宫内环境对胚胎发育的影响。2） 围生期新生儿感染性疾病: 采用血脑屏障的细胞及动物模型，研究新生儿脑膜炎大肠杆菌等病原菌穿过血脑屏障的分子机制。

近期论文

1)Liu R, Wu C, Li L, Chi F, Zhang T, Xu Y, Ji L, Chen Z, Hu H, Zhang X, Huang S, Wang L#.CD48 and α7 nAChR Synergistically Regulate FimH-mediated E. coli K1 Penetration and Neutrophil Transmigration Across Human Brain Microvascular Endothelial Cells. J Infect Dis. 2018 Sep 10. doi: 10.1093/infdis/jiy531. 2）Ji L, Chen Z, Xu Y, Xiong G, Liu R, Wu C, Hu H# and Wang L#. Systematic Characterization of Autophagy in Gestational Diabetes Mellitus. Endocrinology. 2017, 158(8):2522-2532. 3）Zhang, XLΔ(Zhang,Xiao-Li);Wang LΔ(Wang, Lin)(ΔThese authors contributed equally to this work); Xiong L(Xiong,Li);Huang,FH(Huang, Feng-Hua);Xue,H(Xue, Han).Timosapon B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity.EXPERIMENTAL AND THERAPEUTIC MEDICINE 2017,14: 3856-3861. 4）XIAOLI ZHANG, LIN WANG, FENGHUA HUANG, JIAFU LI, LI XIONG, HAN XUE and YUANZHEN ZHANG. Evaluation of the promoter region polymorphism (5 HTTLPR) in the serotonin transporter gene in females with postpartum depression. EXPERIMENTAL AND THERAPEUTIC MEDICINE.2015, 9: 245-249. 5）Zhang X, Wang L, Huang F, Li J, Xiong L, Xue H, Zhang Y. Gene-environment interaction in postpartum depression: a Chinese clinical study. J Affect Disord. 2014 Aug;165:208-12. doi: 10.1016/j.jad.2014.04.049. Epub 2014 Apr 30. 6）Sheng-He HuangΔ*, Lin Wang Δ, Feng ChiΔ（ΔThese authors contributed equally to this work),Chun-Hua Wu1, Hong Cao2, Aimin Zhang1,4, Ambrose Jong1. Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood–brain barrier disorders caused by microbial and non-microbial factors. PLoS One. 2013 Apr 26;8(4):e62164. 7）Lina He, Feng Chi, Tao Bo1, Lin Wang, Chun-Hua Wu, Ambrose Jong, Sheng-He huang* p54nrb, a PSF protein partner, contributes to meningitic Escherichia coli K1-mediated pathogenicities. Open Journal of Applied Sciences 2012, Paper ID:2310016/ojapps. 2012. Published Online 2012 8）Feng ChiΔ, Lin WangΔ(ΔThese authors contributed equally to this work), Xueye Zheng, Chun-Hu Wu, Ambrose Jong,Michael A. Sheard, Wei Chi, Sheng-He Huang*. Meningitic Escherichia coli K1 Penetration and Neutrophil Transmigration Across the Blood–Brain Barrier are Modulated by Alpha7 Nicotinic Receptor. PLOS ONE, 2011,6(9):e25016. 9）Feng ChiΔ, Lin WangΔ（ΔThese authors contributed equally to this work), Xueye Zheng, Ambrose Jong, Sheng-He Huang*. Recruitment of α7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. Future Microbiology, 2011,6:953-66. 10）Xiaojuan CheΔ, Feng ChiΔ, Lin WangΔ(ΔThese authors contributed equally to this work), Timothy D. Jong, Chun-Hu Wu, Xiaoning Wang, Sheng-He Huang*. Involvement of IbeA in meningitic Escherichia coli K1-induced Polymorphonuclear leukocyte transmigration across brain endothelial cells. Brain Pathology .2011,21(4):389-404. 11）Chi F, Jong T, Wang L, Ouyang Y, Wu CH, Li W, Huang SH*. Vimentin-mediated signaling is required.for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cells. Biochem J. 2010, 427:79-90. 12）Wang L, Zou L.Role of caveolin - 1 in the entry of HCMV into human extravillous trophoblast cells，