个人简历

学习经历： 2004.4~ 2004.7 国家教育行政学院中青班 学习 1996.9～1999.6 湖北医科大学内科学肝脏药理学 医学博士学位 1988.9～1991.7 湖北医科大学药理学 医学硕士学位 1981.9～1986.7 湖北医学院医学系 医学学士学位 主要工作经历与任职： 2012.12～至今 武汉大学基础医学院药理学系 二级教授、博导、系主任、省重点实验室主任 2000.4～2012.12 武汉大学基础医学院药理学系 教授、博导、系主任、副院长 1997.1～2000.3 湖北医科大学药理教研室 副教授 1993.6～1996.12 湖北医科大学药理教研室 讲师 1991.6～1993.5 湖北医科大学药理教研室 助教 1986.7～1988.8 武汉市第三医院内科 住院医师

研究领域

长期从事外源物发育毒理、药物靶标与新药研究，至今已培养和带领了一支稳定、跨学科的新药研发团队，包括教授、副教授及讲师，也有一批来自985/211大学并具有医学、药学、生物学、化学等不同专业背景的研究生。

近期论文

1) Zhou J, Zhu CY, Luo HW, Shen L, Gong J, Wu YM, Magdalou J, Chen LB, Guo Y*, Wang H*. Two intrauterine programming mechanisms of adult hypercholesterolemia induced by prenatal nicotine exposure in male offspring rats. FASEB J. 2018:fj201800172R. (IF: 5.498) 2) Xiao H, Wen YX, Pan ZQ, Shangguan YF, Qin J,Tan Y, Jiang HQ, Li B, Zhang Q, Chen LB* and Wang H*. Increased H3K27ac level of ACE mediates the intergenerational effect of low peak bone mass induced by prenatal dexamethasone exposure in male offspring rats. Cell Death Dis. 2018;9(6):638. (IF: 5.965) 3) Lu J, Jiao ZX, Yu Y, Zhang C, He X, Li Q, Xu D*, Wang H*. Programming for increased expression of hippocampal GAD67 mediated the hypersensitivity of the hypothalamic-pituitary-adrenal axis in male offspring rats with prenatal ethanol exposure. Cell Death Dis. 2018;9(6):659. (IF: 5.965) 4) Xu D, Luo HW, Hu W, Hu SW, Yuan C, Wang GH, Zhang L, Yu H, Magdalou J, Chen LB*, Wang H*. Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring. FASEB J. 2018:fj201701557R. (IF: 5.498) 5) Tie K, Wu M, Deng Y, Wen YX, Xu D, Chen LB*, Wang H*. Histone hypo-acetylation of Sox9 mediates nicotine-induced weak cartilage repair by suppressing BMSC chondrogenic differentiation. Stem Cell Res Ther. 2018;9(1):98. (IF: 4.211) 6) Lv F, Wan Y, Chen YX, Pei LG, Luo DJ, Fan GL, Luo MC, Xu D*, Wang H*. Prenatal dexamethasone exposure induced ovarian developmental toxicity and transgenerational effect in rat offspring. Endocrinology. 2018;159(3):1401-15. (IF: 4.286) 7) Ni QB, Lu KH, Li J, Tan Y, Qin J, Jacques Magdalou, Chen LB*, Wang H*. Role of TGFβ signaling in maternal ethanol-induced fetal articular cartilage dysplasia and adult onset of osteoarthritis in male rats. Toxicol Sci. 2018;164(1):179-90. (IF: 4.081) 8) Shangguan Y, Jiang H, Pan ZQ, Xiao H, Tan Y, Tie K, Qin J, Deng Y, Chen LB*, Wang H*. Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats. Cell Death Dis. 2017;8:e3157. (IF: 5.965) 9) Qi YJ, Luo HW, Hu SW, Wu YM, Magdalou J, Chen LB*, Wang H*. Effects and interactions of prenatal ethanol exposure, a post-weaning high-fat diet and gender on adult hypercholesterolemia occurrence in offspring rats. Cellular Physiol Biochem. 2017;44:657-70. (IF: 5.104) 10) Zhang XR*, Shangguan YF, Ma J, Hu H, Wang LL, Magdalou J, Chen LB, Wang H*. Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats. Br J Pharmacol. 2016;173(14):2250-62. (IF:5.491)