个人简历

学习经历： 1995.9－1999.6 北京大学生命科学学院，本科生，获学士学位 1999.9－2004.6 北京大学生命科学学院，硕博连读研究生，获博士学位， 2001.3－2002.6 美国国立犹太医学研究中心，交换学生。 主要工作经历与任职情况： 2004.9－2007.3 耶鲁大学医学院，博士后 2007.4－2009.2 美国Stowers医学研究所，博士后 2009.3至今 武汉大学生命科学学院，教授，博士生导师

研究领域

1）细胞内组蛋白甲基化等表观遗传标记建立、维持和遗传的分子调控机制；2）天然免疫相关的信号转导通路的表观遗传调控机制；3）恶性肿瘤发生发展过程的表观遗传调控机制。

近期论文

1. Zhu, Kun; Lei, Pin-Ji; Ju, Lin-Gao; Wang, Xiang; Huang, Kai,; Yang, Bo; Shao, Changwei; Zhu, Yuan; Wei, Gang; Fu, Xiang-Dong; Li, lianyun; Wu, Min*. The?SPOP-containing Complex Functions as an E3 Ligase for SETD2 to Regulate Gene-Specific H3K36me3-Coupled Alternative Splicing. Nucleic Acids Research, Advance Access published September 9, 2016. 2. Shuai-Kun Su, Chun-Yuan Li, Pin-Ji Lei, Xiang Wang, Quan-Yi Zhao, Yang Cai, Zhen Wang, Lianyun Li*, and Min Wu*. EZH1/SUZ12 complex positively regulates the transcription of NF-κB target genes via interaction with UXT. J Cell Sci. 2016, Jun 15;129(12):2343-53. (*corresponding authors) 3. Quan-Yi Zhao, Pin-Ji Lei, Xiaoran Zhang, Jun-Yi Zheng, Hui-Yi Wang, Jiao Zhao, Yi-Ming Li, Mei Ye, Lianyun Li, Gang Wei*, Min Wu*. Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. Clinical Epigenetics. 2016, 8:34. (*corresponding authors) 4. Kun Zhu, Xiang Wang, Lin-Gao Ju, Yuan Zhu, Jie Yao, Yanyi Wang, Min Wu*, Lianyun Li*. WDR82 negatively regulates cellular antiviral response by mediating TRAF3 poly-ubiquitination in multiple cell lines. J Immunol. 2015 Dec 1;195(11):5358-66. (*corresponding authors) 5. Jia-Dong Fan, Pin-Ji Lei, Jun-Yi Zheng, Xiang Wang, Shangze Li, Huan Liu, Yi-Lei He, Zhao-Ning Wang, Gang Wei, Xiaodong Zhang, Lian-Yun Li*, Min Wu*. The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death. Plos One. 2015 Jan 6;10(1):e0116782. (*corresponding authors) 6. Xiang Wang; Lingao Ju; Jiadong Fan; Yuan Zhu; Xiaolan Liu; Kun Zhu; Min Wu*; Lianyun Li*. Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation. Biochim Biophys Acta-MCR. 2014 Nov;1843 (11):2592-602. Epub 2014 Jun 28. (*corresponding authors) 7. Shuaikun Su, Min Zhang, Lianyun Li, Min Wu*. Polycomb Group Genes as the Key Regulators in Gene Silencing. Wuhan University Journal of Natural Science, February 2014, Volume 19, Issue 1, pp 1-7. 8. Quanyi Zhao, Jiadong Fan, Wei Hong, Lianyun Li*, Min Wu*. Inhibition of cancer cell proliferation by 5-fluoro-2’-deoxycytidine, a DNA methylation inhibitor, through activation of the DNA damage response pathway. Springer Plus. 2012, 1:65 . (*corresponding authors) 9. Xiang Wang, Kun Zhu, Shangze Li, Yifang Liao, Runlei Du, Xiaodong Zhang, Hong-Bing Shu, An-Yuan Guo, Lianyun Li*, and Min Wu*. MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation of genes downstream of NF-κB. J Cell Sci. 2012 Sep 1;125(Pt 17):4058-66. Epub 2012 May 23. (*corresponding authors) 10. Min Wu*, Hong-Bing Shu*. MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. Chin J Cancer. 2011 Apr;30(4):240-6. (*corresponding authors) 11. Min Wu#, Peng Fei Wang#, Jung Shin Lee, Skylar Martin-Brown, Laurence Florens, Michael Washbrun and Ali Shilatifard. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol. 2008 Dec;28(24):7337-44. (#co-first authors). 12. Leigh Ann Higa#, Min Wu#, Tao Ye, Ryuji Kobayashi, Hong Sun and Hui Zhang. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol. 2006 Nov;8(11):1277-83. (#co-first authors). 13. Damon Banks#, Min Wu#, Leigh Ann Higa, Nadia Gavrilova, Junmin Quan, Tao Ye, Ryuji Kobayashi, Hong Sun, Hui Zhang. L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Cell Cycle. 2006 Aug;5(15):1719-29. (#co-first authors). 14. Min Wu, Liang-Guo Xu, Tian Su, Yang Tian, Jun Huang, Zhonghe Zhai, Hong-Bing Shu. AMID is a p53-inducible gene down-regulated in tumors. Oncogene, 2004, vol. 23, 6815-6819. 15. Min Wu, Liang-Guo Xu, Zhonghe Zhai and Hong-Bing Shu. SINK is a p65-interacting Negative Regulator of NF-κB-dependent Transcription. Journal of Biological Chemistry, 2003, Vol. 278, 27072-27079. 16. Min Wu#, Liang-Guo Xu#, Xiaoyan Li, Zhonghe Zhai and Hong-bing Shu. AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. Journal of Biological Chemistry, 2002, Vol. 277, 25617-25623. (#co-first authors). 17. Liang-Guo Xu#, Min Wu#,Jiancheng Hu, Zhonghe Zhai and Hong-Bing Shu. Identification of downstream genes up-regulated by the tumor necrosis factor member TALL-1. Journal of Leukocyte Biology 2002, Vol. 72, 410-416. (#co-first authors).