个人简历

学习经历　Education： 1993-1996：美国普林斯顿大学，分子生物学，博士后。Postdoctoral Associate in Molecular Biology, Princeton University, NJ, USA. 1989-1992：美国爱达华大学，生物化学，博士。Ph.D. in Biochemistry, University of Idaho, ID, USA. 1982-1985：武汉大学，病毒学，硕士。M.S. in Virology, Wuhan University, Wuhan, China. 1978-1982：武汉大学，微生物学，学士。B.S. in Microbiology, Wuhan University, Wuhan, China. 工作经历　Work Experience： 2010-至今：武汉生物技术研究院，副院长。Vice President, Wuhan Institute of Biotechnology, Wuhan, China. 2005-至今：病毒学国家重点实验室，主任。Director, State Key Laboratory of Virology, Wuhan, China. 1999-至今：教育部长江学者奖励计划，特聘教授。Distinguished Professor of Virology, Cheung Kong Scholars Program, Ministry of Education, China. 1999-至今：武汉大学生命科学学院，教授、博士生导师。Professor and Doctoral Supervisor, College of Life Sciences, Wuhan University, Wuhan, China. 1996-1999：美国普林斯顿大学，研究员。Research Staff Member, Princeton University, NJ, USA. 1992-1993：美国爱达华大学，副研究员。Research Associate, University of Idaho, ID, USA. 1986-1989：美国佐治亚大学，访问学者。Visiting Scholar, University of Georgia, GA, USA. 1985-1986：武汉大学，讲师。Lecturer, Wuhan University, Wuhan, China.

研究领域

病毒感染与致病的分子机理

近期论文

1. Chen YN, Chen JB, Wang H, Shi JJ, Wu KL, Liu S, Liu YL, Wu JG (2013). HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog 9(4):e1003248. (IF:9.629) 2. Xia C, Chen YC, Gong H, Zeng WB, Vu GP, Trang P, Lu SW, Wu JG, Liu FY (2013). Inhibition of hepatitis B virus gene expression and replication by ribonuclease P. Mol Ther 21(5):995-1003. (IF:6.284) 3. Cao YH, Zhang W, Yu Y, Zhu CL, Zhang R, Song Y, Wang Q, Bai L, Liu YL, Wu KL, Wu JG (2013). IL-27, a cytokine, and IL-29, a type III interferon, are coordinated to regulate virus replication in a manner similar to type I interferon. J Immunol (Accepted) (IF:5.745) 4. Xu P, Huang ZX, Gao XD, Michel FJ, Hirsch G, Hogan RJ, Sakamoto K, Ho WZ, Wu JG, He B (2013). Infection of mice, ferrets, and rhesus macaques with a clinical mumps virus isolate. J Virol 87(14):8158-8168. (IF:5.189) 5. Yu Y, Cao YH, Sun ZC, Zhang W, Wu KL, Wu JG (2013). Hepatitis B e antigen activates the suppressor of cytokine signaling-2 to antagonize type I and type III interferon and mediate viral immune evasion. Eur J Immunol (In reversion) (IF:4.970) 6. Zhang Z, Vu GP, Gong H, Xia C, Chen YC, Liu FY, Wu JG, Lu SW (2013). Engineered external guide sequences are highly effective in inhibiting gene expression and replication of hepatitis B virus in cultured cells. PLoS One 8(6):e65268. (IF:4.411) 7. Liu S, Hao Q, Wang Y, Yue X, Peng NF, Chen YN, Wu JG, Zhu Y (2012). Major vault protein: A virus-induced host factor against viral replication through the induction of type-I interferon. Hepatology 56(1):57-66. (IF:11.665) 8. Yue X, Wang H, Zhao F, Liu S, Wu JG, Ren W, Zhu Y (2012). Hepatitis B virus-induced calreticulin protein is involved in interferon resistance. J Immunol 189(1):279-286. (IF:5.745) 9. Liu L, Cao ZY, Chen J, Li R, Cao YH, Zhu CL, Wu KL, Wu JG, Liu F, Zhu Y (2012). Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. J Biol Chem 287(15):11899-11910. (IF:5.328) 10. Li YX, Zhang Q, Liu Y, Luo Z, Kang L, Qu J, Liu WY, Xia XS, Liu YL, Wu KL, Wu JG (2012). Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways. J Virol 86(23):12531-12543. (IF:5.189) 11. Zhang Q, Gong R, Qu J, Zhou YJ, Liu WY, Chen MZ, Liu YL, Zhu Y, Wu JG (2012). Activation of the Ras/Raf/MEK pathway facilitates HCV replication via attenuation of the INF-JAK-STAT pathway. J Virol 86(3):1544-1554. (IF:5.189) 12. Fang JL, Liu L, Li YK, Wu JG, Huo XX, Zhu Y (2012). Epigenetic changes mediated by miR29 activate cyclooxygenase-2 and interferon-1 production during viral infection. J Virol 86(2):1010-1020. (IF:5.189) 13. Xu P, Luthra PY, Li Z, Fuentes S, D’Andrea J, Wu JG, Rubin S, Rota P, He B (2012). The V protein of mumps virus plays a critical role in pathogenesis. J Virol 86(3):1768-1776. (IF:5.189) 14. Zeng WB, Chen YC, Bai Y, Trang P, Vu GP, Lu SW, Wu JG, Liu FY (2012). Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme. PLoS One 7(12):e51855. (IF:4.411) 15. Li CW, Yu S, Zhong XL, Wu JG, Li XD (2012). Circadian rhythms of fetal liver transcription persist in the absence of canonical circadian clock gene expression rhythms in vivo. PLoS One 7(2): e30781. (IF:4.411) 16. Li CW, Yu S, Zhong XL, Wu JG, Li XD (2012). Transcriptome comparison between fetal and adult mouse livers: Implications for circadian clock mechanisms. PLoS One 7(2): e31292. (IF:4.411) 17. Chen YN, Shen A, Rider PJ, Yu Y, Wu KL, Mu YX, Hao Q, Liu YL, Gong H, Zhu Y, Liu FY, Wu JG (2011). A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. FASEB J 25(12):4511-4521. (IF:6.515) 18. Yu Y, Gong R, Mu YX, Chen YN, Zhu CL, Sun ZC, Chen MZ, Liu YL, Zhu Y, Wu JG (2011). Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, interleukin-29, interleukin-8, and cyclooxygenase-2. J Immunol 187(9):4844-4860. (IF:5.745)