个人简历

学习经历 1996.10-2001.3 日本京都大学大学院工学研究科合成及生物化学专业 博士 1989.9 -1992.7 武汉大学生命科学学院微生物学专业 硕士 1985.9 -1989.7 武汉大学生物系微生物学专业 学士 工作经历 2003.11-现在 武汉大学生命科学学院微生物学系 副教授、教授 2001.4-2003.8 日本国立产业技术综合研究所生物情报解析研究中心博士后 (JSPS Fellow) 1992.7-1996.9 武汉大学生命科学学院微生物学系 助教、讲师

研究领域

极端古菌分子生物学，重点探讨极端嗜盐、嗜热古菌适应极端环境的分子 机理，目前正致力于极端古菌蛋白分泌机制的研究。

近期论文

1.　Li M, Yin J, Mei S, Wang X, Tang XF*,Tang B* (2018) Halolysin SptA, a serine protease, contributes to growth-phase transition of haloarchaeonNatrinemasp. J7-2, and its expression involves cooperative action of multiplecis-regulatory elements. Front Microbiol. 9:1799. 2.　Perveen S, Rashid N, Tang XF, Imanaka T, Papageorgiou AC* (2017) Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a unique dimeric structure. FEBS Open Bio. 7(8):1217-30. 3.　Gao X, Zeng J, Yi H, Zhang F, Tang B*, Tang XF* (2017) Four inserts within the catalytic domain confer extra stability and activity to hyperthermostable pyrolysin from Pyrococcus furiosus. Appl Environ Microbiol 83(5).pii:e03228-16. 4.　Zhu F,Yang X, Wu Y, Wang Y, Tang XF, Tang B* (2017) Release of an HtrA-like protease from the cell surface of thermophilic Brevibacillus sp. WF146 via substrate-induced autoprocessing of the N-terminal membrane anchor. Front Microbiol 8:481. 5.　Tang W, Wu Y, Li M, Wang J, Mei S, Tang B*, Tang XF* (2016) Alternative translation initiation of a haloarchaeal serine protease transcript containing two in-frame start codons. J Bacteriol. 198(13):1892-901. (Spotlight article) 6.　Liu F, Zhao ZS, Ren Y, Cheng G, Tang XF, Tang B* (2016) Autocatalytic activation of a thermostable glutamyl endopeptidase capable of hydrolyzing proteins at high temperatures. Appl Microbiol Biotechnol 100(24):10429-41. 7.　Meng D, Dai M, Xu BL, Zhao ZS, Liang X, Wang M, Tang XF, Tang B* (2016) Maturation of fibrinolytic bacillopeptidase F involves both hetero- and autocatalytic processes. Appl Environ Microbiol 82(1):318-27. 8.　Xu BL, Dai M, Chen Y, Meng D, Wang Y, Fang N, Tang XF, Tang B* (2015) Improving the thermostability and activity of a thermophilic subtilase by incorporating structural elements of its psychrophilic counterpart. Appl Environ Microbiol 81(18):6302-13. 9.　Wang L, Cheng G, Ren Y, Dai Z, Zhao ZS, Liu F, Li S, Wei Y, Xiong J, Tang XF, Tang B* (2015) Degradation of intact chicken feathers by Thermoactinomyces sp. CDF and characterization of its keratinolytic protease. Appl Microbiol Biotechnol 99(9): 3949-59. 10.　Du X, Li M, Tang W, Zhang Y, Zhang L, Wang J, Li T, Tang B, Tang XF* (2015) Secretion of Tat-dependent halolysin SptA capable of autocatalytic activation and its relation to haloarchaeal growth. Mol Microbiol 96(3):548-65. 11.　Zhang Y, Wang M, Du X, Tang W, Zhang L, Li M, Wang J, Tang B, Tang XF* (2014) Chitin accelerates activation of a novel haloarchaeal serine protease that deproteinizes chitin-containing biomass. Appl Environ Microbiol 80(18):5698-708. 12.　Zeng J, Gao X, Dai Z, Tang B, Tang XF* (2014) Effects of metal ions on stability and activity of hyperthermophilic pyrolysin and further stabilization of this enzyme by modification of a Ca2+-binding site. Appl Environ Microbiol 80(9):2763-72. 13.　Feng J, Wang J, Zhang Y, Du X, Xu Z, Wu Y, Tang W, Li M, Tang B, Tang XF* (2014) Proteomic analysis of the secretome of haloarchaeon Natrinema sp. J7−2. J Proteome Res 13(3):1248-58. 14.　Zhu H, Xu BL, Liang X, Yang YR, Tang XF, Tang B* (2013) Molecular basis for auto- and hetero-catalytic maturation of a thermostable subtilase from thermophilic Bacillus sp. WF146. J Biol Chem 288(48):34826-38. 15.　Li XG*, Yang J, Wang R, Tang XF, Meng JJ, Qin HJ, Liu X, Guo F, Wan SB* (2013) Effects of ectopically expressed hyperthermophilic archaeon (Pyrococcus furiosus) ribulose-1,5-bisphosphate carboxylase/oxygenase on tobacco photosynthesis. Photosynthetica 51 (3): 387-94. 16.　Feng J, Liu B, Zhang Z, Ren Y, Li Y, Gan F, Huang Y, Chen X, Shen P, Wang L, Tang B*, Tang XF* (2012) The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable of growth on synthetic media without amino acid supplements. PLoS ONE 7(7):e41621. 17.　Dai Z, Fu H, Zhang Y, Zeng J, Tang B, Tang XF* (2012) Insights into the maturation of hyperthermophilic pyrolysin and the roles of its N-terminal propeptide and long C-terminal extension. Appl Environ Microbiol 78(12):4233-41. 18.　Xu Z, Du X, Li T, Gan F, Tang B, Tang XF* (2011) Functional Insight into the C-Terminal Extension of Halolysin SptA from Haloarchaeon Natrinema sp. J7. PLoS ONE 6(8):e23562. 19.　Liang X, Bian Y, Tang XF, Xiao G, Tang B* (2010) Enhancement of keratinolytic activity of a thermophilic subtilase by improving its autolysis resistance and thermostability under reducing conditions. Appl Microbiol Biotechnol 87:999–1006.