个人简历

学习背景\r
1988.9―1992.7 江西农业大学 攻读植物遗传育种专业学士学位\r
1997.9―2001.3 华中农业大学 攻读生物化学与分子生物学专业硕士学位\r
2001.3―2004.3 上海交通大学 攻读生物化学与分子生物学专业博士学位\r
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工作经历\r
1992.7―1998.9 江西农业大学 生物技术研究开发中心，研究实习员\r
1998.9―2002.10 江西农业大学 生物技术研究开发中心，助理研究员\r
2002.10―2006.11 江西农业大学 生物工程系，副教授\r
2006.11―2009.11 江西农业大学 生物工程与技术学院，教授\r
2005.1―2010.5 剑桥大学 生物化学系，Royal Society China Fellow、Senior Research Associate\r
2010.5―现在 武汉大学 药学院，教授、湖北省“楚天学者教授计划”入选者

研究领域

"""""微生物来源天然产物生物合成的分子遗传学、生物化学及合成生物学\r
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微生物来源活性天然产物生物合成途径的解析与药物创新\r
以具有重要基础和应用价值的微生物天然产物为研究对象，从分子遗传学、生物化学及合成生物学的角度探索其生物合成机理，并回答其生物合成中蕴藏的关键科学问题，为新药创制提供精确的“分子装配线路图”。同时，通过代谢途径的理性设计和定向优化，有的放矢地改造天然产物生物合成途径，实现微生物药物的高产和创新。\r
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DNA编辑新技术的探究与应用\r
侧重于DNA编辑机制的探索和工具的开发，并综合运用DNA编辑技术对靶向基因（簇）进行高效克隆和编辑"

近期论文

Guo Sun, Chaoqun Hu, Qing Mei, Minghe Luo, Xu Chen, Zhengyuan Li, Yuanzhen Liu, Zixin Deng, Zhengyu Zhang* and Yuhui Sun*, Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nature Communications 2020, 11: 4501.\r
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Guifa Zhai#, Wenyan Wang#, Wei Xu, Guo Sun, Chaoqun Hu, Xiangming Wu, Zisong Cong, Liang Deng, Yanrong Shi, Peter F. Leadlay, Heng Song, Kui Hong, Zixin Deng and Yuhui Sun*, Cross-module enoylreduction in the azalomycin F polyketide synthase. Angewandte Chemie International Edition 2020, 59: 2-7.\r
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Minghe Luo, Lingjie Tang, Yulu Dong, Hongbo Huang, Zixin Deng and Yuhui Sun*, Antibacterial natural products lobophorin L and M from the marine-derived Streptomyces sp. 4506. Natural Product Research (Online ahead of print).\r
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Yuanzhen Liu*, Xu Chen, Zhengyuan Li, Lixia Huang and Yuhui Sun*, Ansavaricin J, a new heterocyclic ring-fused streptovaricin from gene stvP5-deleted mutant of Streptomyces spectabilis CCTCC M2017417. Chemistry & Biodiversity 2020, 17: e1900713.\r
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Yao Liu#, Yuanzhen Liu#, Zixiu Du#, Lidan Zhang, Juan Chen, Zhen Shen, Qian Liu, Juanxiu Qin, Huiying Lv, Hua Wang, Lei He, Junlan Liu, Qian Huang, Yuhui Sun*, Michael Otto* and Min Li*, Skin microbiota analysis-inspired development of novel anti-infectives. Microbiome 2020, 8: 85.\r
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Sicong Li#, Qian Liu#, Zhiyu Zhong, Zixin Deng and Yuhui Sun*, Exploration of hygromycin B biosynthesis utilizing CRISPR-Cas9-associated base editing. ACS Chemical Biology 2020, 15: 1417-1423.\r
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Rory Little, Fernanda C. R. Paiva, Robert Jenkins, Hui Hong, Yuhui Sun, Yuliya Demydchuk, Markiyan Samborskyy, Manuela Tosin, Finian J. Leeper, Marcio V. B. Dias and Peter F. Leadlay*, Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis. Nature Catalysis 2019, 2: 1045-1054.\r
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Weixin Tao*, Li Chen, Chunhua Zhao, Jing Wu, Dazhong Yan, Zixin Deng and Yuhui Sun*, In vitro packaging mediated one-step targeted cloning of natural product pathway. ACS Synthetic Biology 2019, 8: 1991-1997.\r
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Zhiyu Zhong#, Junhong Guo#, Liang Deng, Li Chen, Jian Wang, Sicong Li, Wei Xu, Zixin Deng and Yuhui Sun*, Base editing in Streptomyces with Cas9-deaminase fusions. bioRxiv 2019 (doi: https://doi.org/10.1101/630137).\r
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Jingjing Zhou, Chengbin Qiu, Ni Pi, Sicong Li, Xiyao Cheng, Lei Zhang, Yao Chen, Yongqi Huang*, Yuhui Sun* and Zhengding Su*, A protein biosynthesis machinery strategy for identifying P53PTC-rescuing compounds as synergic anti-tumor drugs. ChemistrySelect 2018, 3: 11048-11053.\r
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Weixin Tao, Anna Yang, Zixin Deng and Yuhui Sun*, CRISPR/Cas9-based editing of streptomyces for discovery, characterization, and production of natural products. Frontiers in Microbiology 2018, 9: 1660.\r
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Sicong Li#, Jun Zhang#, Yuanzhen Liu, Guo Sun, Zixin Deng and Yuhui Sun*, Direct genetic and enzymatic evidence for oxidative cyclization in hygromycin B biosynthesis. ACS Chemical Biology 2018, 13: 2203-2210.\r
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Yuan Li#, Wan Zhang#, Hui Zhang, Wenya Tian, Lian Wu, Shuwen Wang, Mengmeng Zheng, Jinru Zhang, Chenghai Sun, Zixin Deng, Yuhui Sun, Xudong Qu* and Jiahai Zhou*, Structural basis of a broadly selective acyltransferase from the polyketide synthase of splenocin. Angewandte Chemie International Edition 2018, 57: 5823-5827.\r
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Sicong Li#, Junhong Guo#, Anna Reva, Fanglu Huang, Binbin Xiong, Yuanzhen Liu, Zixin Deng, Peter F. Leadlay* and Yuhui Sun*, Methyltransferases of gentamicin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 2018, 115:1340-1345.\r
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Yuanzhen Liu, Xu Chen, Zhengyuan Li, Wei Xu, Weixin Tao, Jie Wu, Jian Yang, Zixin Deng and Yuhui Sun*, Functional analysis of cytochrome P450s involved in streptovaricin biosynthesis and generation of anti-MRSA analogues. ACS Chemical Biology 2017, 12: 2589-2597.\r
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Priscila dos Santos Bury, Fanglu Huang, Sicong Li, Yuhui Sun, Peter F. Leadlay and Marcio Vinicius Bertacine Dias*, Structural basis of the selectivity of GenN, an aminoglycoside N-methyltransferase involved in gentamicin biosynthesis. ACS Chemical Biology 2017, 12: 2779-2787.\r
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Wei Xu#, Guifa Zhai#, Yuanzhen Liu, Yuan Li, Yanrong Shi, Kui Hong, Hui Hong, Peter F. Leadlay, Zixin Deng and Yuhui Sun*, An iterative module in the azalomycin F polyketide synthase contains a switchable enoylreductase domain. Angewandte Chemie International Edition 2017, 56: 5503-5506.\r
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Marie E. Yurkovich, Robert Jenkins, Yuhui Sun, Manuela Tosin* and Peter F. Leadlay*, The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase. Chemical Communications 2017, 53: 2182-2185.\r
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Judith Havemann, Marie E. Yurkovich, Robert Jenkins, Sophia Harringer, Weixin Tao, Shishi Wen, Yuhui Sun, Peter F. Leadlay and Manuela Tosin*, Chemical probing of thiotetronate bio-assembly. Chemical Communications 2017, 53: 1912-1915.\r
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Hui Hong, Yuhui Sun, Yongjun Zhou, Emily Stephens, Markiyan Samborskyy and Peter F. Leadlay*, Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase. Beilstein Journal of Organic Chemistry 2016, 12: 2164-2172.\r
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Jianzhao Qi, Dan Wan, Hongmin Ma, Yuanzhen Liu, Rong Gong, Xudong Qu, Yuhui Sun, Zixin Deng and Wenqing Chen*, Deciphering carbamoylpolyoxamic acid biosynthesis reveals unusual acetylation cycle associated with tandem reduction and sequential hydroxylation. Cell Chemical Biology 2016, 23: 935-944.\r
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Yujie Geng, Zixin Deng and Yuhui Sun*, An insight into the protospacer adjacent motif of Streptococcus pyogenes Cas9 with artificially stimulated RNA-guided-Cas9 DNA cleavage flexibility. RSC Advances 2016, 6: 33514-33522.\r
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Weixin Tao#, Marie E. Yurkovich#, Shishi Wen#, Karen E. Lebe, Markiyan Samborskyy, Yuanzhen Liu, Anna Yang, Yunkun Liu, Yingchen Ju, Zixin Deng, Manuela Tosin, Yuhui Sun* and Peter F. Leadlay*, A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis. Chemical Science 2016, 7: 376-385.\r
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Yunkun Liu#, Weixin Tao#, Shishi Wen, Zhengyuan Li, Anna Yang, Zixin Deng and Yuhui Sun*, In vitro CRISPR/Cas9 system for efficient targeted DNA editing. mBio 2015, 6:e 01714-15.\r
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Hu Zeng, Shishi Wen, Wei Xu, Zhaoren He, Guifa Zhai, Yunkun Liu, Zixin Deng and Yuhui Sun*, Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system. Applied Microbiology and Biotechnology 2015, 99: 10575-10585.\r
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Chuan Huang#, Fanglu Huang#, Eileen Moison, Junhong Guo, Xinyun Jian, Xiaobo Duan, Zixin Deng, Peter F. Leadlay* and Yuhui Sun*, Delineating the biosynthesis of gentamicin X2, the common precursor of the gentamicin C antibiotic complex. Chemistry & Biology 2015, 22: 251-261.\r
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Junhong Guo#, Fanglu Huang#, Chuan Huang, Xiaobo Duan, Xinyun Jian, Finian Leeper, Zixin Deng, Peter F. Leadlay* and Yuhui Sun*, Specificity and promiscuity at the branch point in gentamicin biosynthesis. Chemistry & Biology 2014, 21:608-618.\r
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Yuhui Sun*, A carbonate architect emerges. Nature Chemical Biology 2014, 10:486-487. (Invited Comments)\r
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Yanling Ma, Wei Xu, Jun Zhang, Sihong Zhang, Kui Hong, Zixin Deng and Yuhui Sun*, Nitrilase superfamily aryl acylamidase from the halotolerant mangrove Streptomyces sp. 211726. Applied Microbiology and Biotechnology 2014, 98: 8583-8590.\r
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Weixin Tao#, Manghong Zhu#, Zixin Deng and Yuhui Sun*, Biosynthesis of tetronate antibiotics: A growing family of natural products with broad biological activities. Science China Chemistry 2013, 56: 1364-1371. (Invited Review)\r
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Chompoonik Kanchanabanca#, Weixin Tao#, Hui Hong, Yajing Liu, Frank Hahn, Markiyan Samborskyy, Zixin Deng, Yuhui Sun* and Peter F. Leadlay*, Unusual acetylation-elimination in the formation of tetronate antibiotics. Angewandte Chemie International Edition 2013, 52: 5785-5788.\r
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Marie E. Yurkovich, Petros A. Tyrakis, Hui Hong, Yuhui Sun, Markiyan Samborskyy, Kohei Kamiya and Peter F. Leadlay*, A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster. ChemBioChem 2012, 13: 66-71.\r
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Jeroen S. Dickschat, Olivia Vergnolle, Hui Hong, Stephen Garner, Susanna R. Bidgood, Hannah C. Dooley, Zixin Deng, Peter F. Leadlay* and Yuhui Sun*, An additional dehydratase-like activity is required for lankacidin antibiotic biosynthesis. ChemBioChem 2011, 12: 2408-2412.