个人简历

学习经历： 2005—2010 美国加州理工学院（Caltech），博士后/研究助理 2000—2005 中国科学技术大学，博士 1995—1999 安徽大学，本科 主要工作经历与任职情况： 2011/01 至今， 武汉大学生命科学学院，教授，博导

研究领域

1）肿瘤细胞代谢；2）线粒体动力学

近期论文

1.Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z.* (2018) Sam50 determines mitochondrial clearance by regulating mitochondrial shape and Pink1-Parkin-mediated mitophagy. Cell Reports. 23(10), 2989-3005 2.Khan M, Xiang S, Song Z* and Mian W* (2017) TRINGS, a p53 inducible long noncoding RNA protects cancer cells from necrosis under glucose starvation. EMBO Journal. 2017 36(23):3483-3500 (co-corresponding author) 3.Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z*. (2016) Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization. Cell Death and Differentiation. 23(3):380-92. 4.Zhang K, Li H, Song Z.* (2014) Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage. EMBO Reports, 15(5):576-85 5.Ruan Y, Li H, Zhang K, Jian F, Tang J, Song Z.* (2013) Loss of Yme1L perturbates mitochondrial dynamics. Cell Death & Disease, 4: e896. doi: 10.1038/cddis.2013.414 6.Losón OC, Song Z, Chen H, Chan DC. (2013) Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Molecular Biology of the Cell. 24(5):659-67. 7.Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J. (2012) Regulation of mitochondrial permeability transition pore by PINK1. Molecular neurodegeneration. 7:22. 8.Lin Miao#, Zhiyin Song#, Lei Jin, YouMing Zhu and Mian Wu (2010) ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation. Oncogene, 29(5):711-722 (co-first author) 9.Zhiyin Song, Mariam Ghochani, Terry Frey and David C. Chan (2009) Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Molecular Biology of the Cell, (15):3525-3532 10.Zhiyin Song, Hsiuchen Chen, Maja Fiket, Christiane Alexander, and David C. Chan (2007) OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L Journal of Cell biology 178(5):749-755 11.Li Ma, Yafeng Huang, Zhiyin Song, Shanshan Feng, Xu Tan and Mian Wu (2006) Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway Cell Death and Differentiation. 13(12):2079-88. 12.De-e Zhu, Hoti Naser, Zhiyin Song, Lei Jing and Mian Wu (2006) Suppression of tumor growth using a recombinant adenoviral vector carrying the dominant-negative mutant gene Survivin-D53A in a nude mice model. Cancer Gene Therapy .13(8):762-70 13.Zhiyin Song and Mian Wu. (2005) Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation. Oncogene. 14; 24(16): 2723-2734 14.Zhiyin Song, Shixin Liu, He He, Yi Wang, Shanshan Feng and Mian Wu. (2004) A Single Amino Acid Change (Asp 53->Ala53) Converts Survivin from anti-apoptotic to pro-apoptotic. Molecular Biology of the Cell. 15(3):1287-1296 15.Zhiyin Song, Xuebiao Yao and Mian Wu (2003) Direct interaction between Survivin and Smac is essential for the anti-apoptotic activity of Survivin during Taxol-induced apoptosis Journal of Biological Chemistry 278(25): 23130-23140