个人简历

学习经历： 2003.09 – 2006.12 武汉大学生命科学学院 博士 2000.09 – 2003.06 武汉大学生命科学学院 硕士 1990.09 – 1994.06 武汉大学生命科学学院 学士 主要工作经历与任职情况： 2009.11 – 至今 武汉大学生命科学学院 副教授，硕士研究生导师 2012.01 – 2012.12 美国纽约州奥尔巴尼医学院 访问学者 2007.02 – 2009.11 武汉大学生命科学学院 讲师 1994.07 – 2000.08 湖北中医药大学基础部 教师

研究领域

1、利用cDNA文库构建、mRNAs和microRNAs表达谱芯片、组织芯片等现代实验技术，结合生物信息学、分子生物学、细胞生物学等研究方法和技术手段，筛选与人类早期胚胎发育相关的新基因（包括蛋白编码基因和microRNAs基因）；2、与人类早期胚胎发育相关新基因的转录调控研究及其在人胚分子发育和恶性肿瘤发生发展过程中的生物学功能探索。

近期论文

1) Wei Wang, Jinyang Cai, Yi Lin, Zikou Liu, Qihao Ren, Li Hu, Zan Huang, Mingxiong Guo #, and Wenxin Li #. Zinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-containing Zinc Finger Proteins. PLoS One, 2014, Mar 19; 9(3):e92155 2) Yi Lin, Yan Zeng, Fan Zhang, Lu Xue, Zan Huang, Wenxin Li #, Mingxiong Guo #. Characterization of MicroRNA Expression Profiles and the Discovery of Novel MicroRNAs Involved in Cancer during Human Embryonic Development. PLoS ONE 2013, 8(8): e69230. 3) Wei Wang *, Jinyang Cai *, Yingliang Wu, Jun Hu, Zongyun Chen, Wenxin Li, Mingxiong Guo #, Zan Huang #. KRAB domain functions as a novel nuclear localization signal by interacting with KAP1. Cell Mol Life Sci., 2013, 70(20): 3947-3958. 4) Li Hu *, Wei Wang *, Jinyang Cai, Jun Luo, Yi Huang, Shilu Xiong, Wenxin Li, Mingxiong Guo #. Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Oncol Lett., 2013, 6: 49-54. 5) Hai-Ming Hu, Yicheng Chen, Lu Liu, Chuan-Geng Zhang, Wei Wang, Ke Gong, Zan Huang, Ming-Xiong Guo, Wen-Xin Li # and Wenhua Li #. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. FASEB J., 2013, 27(1): 163-73 6) Wei Wang *, Mingxiong Guo *, Li Hu, Jinyang Cai, Yan Zeng, Jun Luo, Zhiqiang Shu, Wenxin Li #, Zan Huang #. The Zinc Finger Protein ZNF268 is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling. J. Biol. Chem., 2012, 287(51): 42856-66. 7) Yan Zeng, Wei Wang, Jian Ma, Xianguo Wang, Mingxiong Guo #, Wenxin Li #. Knockdown of ZNF268, Which Is Transcriptionally Downregulated by GATA-1, Promotes Proliferation of K562 Cells. PLoS ONE., 2012, 7(1): e29518. 8) Lu Xue *, Hong-Ling Qiu *, Jian Ma, Ming-Xiong Guo, Wen-Xin Li #. ZNF300, A Recently Identified Human Transcription Factor, Activates the Human IL-2R Beta Promoter through the Overlapping ZNF300/Egr1 Binding Site. Cell. Mol. Biol. Lett. 2010, 15(4): 530-40. 9) Hong Yi *, Lu Xue *, Ming-Xiong Guo *, Jian Ma, Yan Zeng, Wei Wang, Jin-Yang Cai, Hai-Ming Hu, Hong-Bing Shu, Yun-Bo Shi #, Wen-Xin Li #.Gene Expression Atlas for Human Embryogenesis. FASEB J. 2010, 24(9): 3341-50. 10) Jun-Hua Xu, Tao Wang, Xian-Guo Wang, Xiang-Peng Wu, Zhou-Zhou Zhao, Chen-Gang Zhu, Hong-Ling Qiu, Lu Xue, Huan-Jie Shao, Ming-Xiong Guo, Wen-Xin Li #. PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. Leukemia Research, 2010, 34(12): 1636-46. 11) Zhouzhou Zhao, Di Wang, Chengang Zhu, Huanjie Shao, Chong Sun, Hongling Qiu, Lu Xue, Junhua Xu, Mingxiong Guo*, Wenxin Li*. Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. Oncol. Rep., 2008, 20(5): 1243-8. 12) Di Wang *, Ming-Xiong Guo *, Zhou-Zhou Zhao, Hong-Ling Qiu, Hai-Ming Hu, Huan-Jie Shao, Chen-Gang Zhu, Lu Xue, Yun-Bo Shi and Wen-Xin Li.Human T-cell leukemiavirus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive Element-binding Protein/Activating Transcription Factor pathway. J. Biol. Chem., 2008, 283(24): 16299-308. 13) Mingxiong Guo, Tao Huang, Yejian Cui, Baiqun Pan, Ao Shen, Yuting Sun, Yourong Yi, Yan Wang, Gengfu Xiao, Guihong Sun. PrPC interacts with tetraspanin-7 through bovine PrP154-182 containing alpha-helix 1. Biochem. Bioph. Res. Co., 2008, 365(1): 154-7. 14) Chengang Zhu, Zhouzhou Zhao, Mingxiong Guo, Huanjie Shao, Hongling Qiu, Di Wang, Junhua Xu, Lu Xue, Wenxin Li. The mammalian gene ZNF268 is regulated by hUpf1. Biochemistry-Moscow, 2008, 73(8): 881-5. 15) Li Xu, Zhouzhou Zhao, Jiqun Sheng, Chenggang Zhu, Hui Liu, Dahe Jiang, Xin Mao, Mingxiong Guo, and Wenxin Li. Co-expression of complement regulatory proteins human DAF and MCP with an IRES-mediated dicistronic mammalian vector enhances their cell protective effects. Biochemistry-Moscow. 2008, 73(9): 1025-30. 16) Hongling Qiu, Lu Xue, Li Gao, Huanjie Shao, Di Wang, Mingxiong Guo and Wenxin Li. Identification of the DNA binding element of the human ZNF300 protein. Cell. Mol. Biol. Lett., 2008, 13(3): 391-403. 17) Ming-Xiong Guo *, Di Wang *, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue, Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi, and Wen-Xin Li.Transcription of Human Zinc Finger ZNF268 Gene Requires an Intragenic Promoter Element. J. Biol. Chem., 2006, 281(34): 24623-36. 18) Shao H, Zhu C, Zhao Z, Guo M, Qiu H, Liu H, Wang D, Xue L, Gao L, Sun C, Li W. KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains. Int. J. Mol. Med., 2006, 18(3): 457-63. 19) Guihong Sun, Mingxiong Guo, Ao Shen, Fanghua Mei, Xiaoxue Peng, Rui Gong, Deyin Guo, Jianguo Wu, Po Tien, Gengfu Xiao. Bovine PrPCdirectly interacts with alpha B-crystalline. FEBS Lett., 2005, 579: 5419-24.