个人简历

学习简历： 2006-2011 中科院上海有机化学研究所，获有机化学博士学位 2002-2006 武汉大学化学系，获学士学位 工作简历： 2018 至今 武汉大学，副研究员 2012-2017 美国布朗大学，博士后研究员 2011-2012 中科院上海有机化学研究所，助理研究员

研究领域

酶学机制、结构生物学、天然药物生物合成

近期论文

1. Lian Duan, Gerwald Jogl and David E. Cane. The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism. J. Am. Chem. Soc., 2016, 138, 12678−12689. 2. Lian Duan, Shoufeng Wang, Rijing Liao and Wen Liu. Insights into Quinaldic Acid Moiety Formation in Thiostrepton Biosynthesis Facilitating Fluorinated Thiopeptide Generation. Chem. Biol., 2012, 19, 443-448. 3. R. Liao, L. Duan, C. Lei, H. Pan, Y. Ding, Q. Zhang, D. Chen, B. Shen, Y. Yu and W. Liu. Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications. Chem. Biol., 2009, 16, 141–147. (Co-first Author). 4. Yi Yu, Lian Duan, Qi Zhang, Rijing Liao, Ying Ding; Haixue Pan, Evelyn Wendt-Pienkowski, Gongli Tang, Ben Shen and Wen Liu. Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework. ACS Chemical Biology, 2009, 4(10), 855-864. 5. Patrick N. Blank, Golda G. Harris, Wayne K. W. Chou, Lian Duan, David E. Cane, and David W. Christianson. Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry, Just Accepted Manuscript. 6. Travis A. Pemberton, Mengbin Chen, Golda G. Harris, Wayne K. W. Chou, Lian Duan, Mustafa Köksal, Alex S. Genshaft, David E. Cane, and David W. Christianson. Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry, 2017, 56 (14), pp 2010–2023. 7. Yi Yu, Heng Guo, Qi Zhang, Lian Duan, Ying Ding, Rijing Liao, Chun Lei, Ben Shen and Wen Liu. NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide. J. Am. Chem. Soc., 2010, 132, 16324–16326. 8. Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen & Wen Liu. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology, 2011, 7, 154–160. 9. Jing Li, Xudong Qu, Xinyi He, Lian Duan, Guojun Wu, Dexi Bi, Zixin Deng, Wen Liu, Hong-Yu Ou. ThioFinder: A Web-Based Tool for the Identification of Thiopeptide Gene Clusters in DNA Sequences. Plos One 2012, 7, e45878. 10. Kai Zhang, Zhao Chen, Chuluo Yang, Xiaowei Zhang, Youtian Tao, Lian Duan, Liang Chen, Linna Zhu, Jingui Qin and Yong Cao. Improving the performance of phosphorescent polymer light-emitting diodes using morphology-stable carbazole-based iridium complexes. J. Mater. Chem., 2007, 17, 3451-3460.