个人简历

Euducation： 1998 – 2003　中科院上海生命科学研究院生化与细胞所 博士 1994 – 1998　北京大学化学与分子工程学院 本科 Research Experience： 2011.12-至今　 武汉大学生命科学院 教授 2010.11-2011.11 美国普渡大学生物化学系 研究科学家 2006.11-2010.10 美国普渡大学生物化学系 博士后 2004.2- 2006.10 美国斯坦福大学生物系 博士后

研究领域

研究表观遗传学、基因表达调控和细胞分裂、增殖及分化相关联的基础问题。

近期论文

1) Cheng, X., Hao, Y., Shu,W., Zhao, M., Zhao, C., Wu, Y., Peng, X., Yao, P., Xiao, D., Qing, G., Pan, Z., Yin, L., Hu, D.*, Du, H.N.* (2017) Cell cycle-dependent Degradation of the Methyltransferase SETD3 Suppresses Cell Proliferation and Liver Tumorigenesis. J Biol. Chem. (coming soon) 2) Li, F., Zheng, L.D., Chen, X., Zhao, X.L., Briggs, S.D., Du, H.N*. (2017) Gcn5-mediated Rph1 acetylation regulates its autophagic degradation under DNA Damage Stress. Nucleic Acids Res. DOI:10.1093/nar/gkx129 3) Hu J.Y., Zhang D.L., Liu X.L., Li X.S., Cheng X.Q., Chen J., Du H.N., Liang Y*. (2016) Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells. Biochim Biophys Acta. 1863: 414-427. 4) Wang H.Y., Li Y., Xue T., Cheng N., Du, H.N.* (2016) Construction of a series of pCS2+ backbone-based Gateway vectors for overexpressing various tagged proteins in vertebrates. Acta Biochim Biophys Sin. 48: 1128-1134. 5) Xiao D, Yue M, Su H, Ren P, Jiang J, Li F, Hu Y, Du, H.N., Liu H, Qing G*. (2016) Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival. Mol Cell. 2016 Nov 3;64(3):493-506. 6) Du, H.N.* (2012) Transcription, DNA damage and beyond: the roles of histone ubiquitination and deubiquitination. Curr Prot & Pept Sci 13:447-466.