个人简历

学习经历： 2005.9-2010.6 华中科技大学同济医学院公共卫生学院, 劳动卫生与环境卫生专业医学博士 2007.10-2009.9 德国图宾根大学医学院脑科研究所 DAAD奖学金博士研究生 1999.9-2002.6 武汉大学医学院药理学硕士 1994.9-1999.6 湖北医科大学临床医学系学士 主要工作经历与任职： 2016.12 - 2017.05 日本京都大学大学院人間・環境学研究科访问教授 2014.10 – 至今 武汉大学基础医学院药理学系教授 2012.7- 2014.7 日本北海道大学齿学院JSPS特别研究员 2002.6-2012.6 华中科技大学同济医学院药学院助教/讲师

研究领域

探索纳米材料与生物机体的相互作用及其细胞分子机制；将纳米材料/药物用于人类疾病的诊断与治疗。当前兴趣：纳米药物递送系统调控肿瘤免疫微环境以及用于肿瘤的免疫治疗。

近期论文

1. TF Li, YH Xu, K Li, C Wang, X Liu, Y Yue, Z Chen, SJ Yuan, Y Wen, Q Zhang, M Han, N Komatsu, L Zhao*, X Chen*. Doxorubicin-polyglycerol-nanodiamond composites stimulate glioblastoma cell immunogenicity through activation of autophagy. Acta Biomater. 2019; In press (IF: 6.38) 2. Z Chen, C Wang, TF Li, K Li, Y Yue, X Liu, HZ Xu , Y Wen, Q Zhang, M Han, N Komatsu, YH Xu, L Zhao*, X Chen*. Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates. Nanomedicine (Lond). 2018; In press. (IF: 5.008) 3. Li TF, Li K, Zhang Q, Wang C, Yue Y, Chen Z, Yuan SJ, Liu X, Wen Y, Han M, Komatsu N, Xu YH, Zhao L*, Chen X*. Dendritic cell-mediated delivery of doxorubicin-polyglycerol-nanodiamond composites elicits enhanced anti-cancer immune response in glioblastoma. Biomaterials. 2018;181:35-52. (IF: 8.806) 4. Li TF, Li K, Wang C, Liu X, Wen Y, Xu YH, Zhang Q, Zhao QY, Shao M, Li YZ, Han M, Komatsu N, Zhao L*, Chen X*. Harnessing the cross-talk between tumor cells and tumor-associated macrophages with a nano-drug for modulation of glioblastoma immune microenvironment. J Control Release. 2017;268:128-146. (IF:7.877) 5. Wang C, Li K, Li T, Chen Z, Wen Y, Liu X, Jia X, Zhang Y, Xu Y, Han M, Komatsu N, Zhao L*, Chen X*. Monocyte-mediated chemotherapy drug delivery in glioblastoma. Nanomedicine (Lond). 2018;13 (2):157-178. (IF: 5.008) 6. ZJ Wang, YH Xu, XN Meng, F Watari, HD Liu*, X Chen*, Suppression of c-Myc is involved in multi-walled carbon nanotubes' down-regulation of ATP-binding cassette transporters in human colon adenocarcinoma cells. Toxicol Appl Pharm. 2015;282(1):42-51.（IF 3.63） 7. L. Zhao, Y. Xu, H. Qin, S. Abe, T. Akasaka, T. Chano, F. Watari, T. Kimura, N. Komatsu*, X. Chen*. Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting peptide, and Acid-Responsive Antitumor Drug. Adv Funct Mater. 2014; 24(34): 5348–5357. （IF 10.439） 8. L. Zhao, Y. Xu, S. Abe, T. Akasaka, T. Watari, T. Kimura, N. Komatsu, X. Chen*. Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells. Biomaterials. 2014; 35(20): 5393–5406.（IF: 8.321）