个人简历

1994 – 2000 华中农业大学生物技术六年制本硕连读专业。 2000 – 2004 获上海交通大学生物化学与分子生物学博士学位。 2001 – 2002 作为访问博士生赴韩国高等科技学院合作研究。 2005 – 2007 赴美国麻省理工学院进行博士后研究。 2007 – 2011 在美国哈佛大学进行研究工作。 2011 - 至今 武汉大学药学院教授。

研究领域

1．基因组修饰及编辑 利用最新发展的前沿技术，对细胞基因组进行精确地修饰和编辑，结合表观遗传学、基因组学、蛋白组学等，发展出特定设计的工程细胞，并解析这些表观遗传学修饰或基因组改造对细胞生命活动的影响。 2．DNA骨架的磷硫酰化生理修饰 与任何DNA或RNA修饰不同，DNA的磷硫酰化是DNA骨架上发现的第一例生理修饰，又称为DNA 骨架上的硫修饰，或DNA的第六元素。入选《环球科学》2007 年度“全球十大科学新闻”。磷硫酰化修饰由dnd 基因簇的一系列基因来完成，在不同的细菌宿主中表现出识别序列特异性，空间构象特异性。磷硫酰化修饰拓展了DNA的元素组成并丰富了DNA 结构，打开了一个新的学科领域。 3．创新药物的设计与改造 依据药物生物合成的机理及对重大疾病致病机理的认识，通过全面的病理分析，合理筛选并设计潜在药物，并通过前沿技术基因组编辑、合成生物学、基因工程、蛋白质工程、代谢工程及组合生物合成途径进行优化改造，发展相应的创新药物和治疗手段，以获得性能改善并可应用于临床的创新药物。

近期论文

1.Chen C, Wang L, Chen S, Wu X, Gu M, Chen X, Jiang S, Wang Y, Deng Z, Dedon P, Chen S*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, doi: 10.1073/pnas.1702450114. 2. Tong T#, Chen S#, Wang L#, Tang Y#, Ryu JY, Jiang S, Wu X, Chao Chen C, Luo J, Deng Z, Li Z, Lee SY*, Shi Chen*. Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018, doi:10.1073/pnas.1721916115. 3. Lei Xiong#, Siyi Liu#, Si Chen#, Yao Xiao#, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of DNA phosphorothioation-based antiviral system in archaea. Nature Communications, 2019, in press, DOI: 10.1038/S41467-019-09390-9. 4. Cao B. #, Chen C. #, DeMott M.S. #, Cheng Q., Clark T.A., Xiong X., Zheng X., Butty V., Levine S.S., Yuan G., Boitano M., Luong K., Song Y., Zhou X., Deng Z., Turner S.W., Korlach J., You D.*, Wang L.*, Chen S.*, Dedon P.C. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications, 2014, 5, doi:10.1038/ncomms4951. 5. Wang L, Chen S*, Vergin KL, Giovannoni SJ, Chan SW, Demott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC*. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A, 2011, 108 (7): 2963-2968. 6. Wang L, Jiang S, Chen C, He W, Wu X, Wang F, Tong T, Zou X, Li Z, Luo J, Deng Z, Chen S*. Synthetic genomes: from DNA synthesis to genome design. Angew Chemie Int Ed., 2018, 57: 2~11. 7. Wang L, Jiang S, Deng Z, Dedon P, Chen S*. DNA phosphorothioate modification – a new multi- functional epigenetic system in bacteria. FEMS Microbiology Reviews, 2019, 43(2), 109–122. https://doi.org/10.1093/femsre/fuy036 8. Chen Y., Deng Z, Jiang S., Hu Q., Liu H., Zhou S., Ma W., Chen S.*, Zhao Y*. Human cells lacking coilin and Cajal bodies areproficient in telomerase assembly, trafficking and telomere maintenance. Nucleic Acids Research, 2014, 1-11, doi: 10.1093/nar/gku1277. 9. Wang F#, Wang L#, Zou X., Duan S., Li Z., Deng Z., Luo J., Lee S. Y.*, Chen S*. Advances in CRISPR-Cas systems for RNA targeting, tracking and editing. Biotechnology Advances, 2019, https://doi.org/10.1016/j.biotechadv.2019.03.016. 10. Zou X#, Wang L#, Li Z, Luo J, Wang Y, Deng Z, Du S, Chen S*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2018, 38(1): 229~260. 11. Deng Z, Purtell K Lachance V, Wold M, Chen S*, Yue Z*. Autophagy Receptors and Neurodegenerative Diseases. Trends in Cell Biology, 2017, 27(7).491~504. doi.org/10.1016/j.tcb.2017.01.001. 12. Wu S#, Wang L# ; Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S*. Signature arsenic detoxification pathways in Halomonas sp. GFAJ-1, mBio, 2018, May 1; 9 (3): e00515-18. doi: 10.1128/mBio.00515-18. 13. Sisi Xia, Jun Chen, Liqiong Liu, Yue Wei, Zixin Deng, Lianrong Wang, Shi Chen*. Tight control of genomic phosphorothioate modification by the ATP-modulated autoregulation and reusability of DndB. Molecular Microbiology, 2018 December, doi: 10.1111/mmi.14186. 14. Huang Q, Wang F, Yuan C, He Z, Rao L, Cai B, Chen B, Jiang S, Li Z, Chen J, Liu W, Guo F, Ao Z*, Chen S*, Zhao X*. Gelatin Nanoparticle-Coated Silicon Beads for Density-Selective Capture and Release of Heterogeneous Circulating Tumor Cells with High Purity. Theranostics, 2018, 8(6): 1624~1635 15. Liu L, Zhang Y, Jiang D, Du S, Deng Z, Wang L, and Chen S*. Recent Advances in the Genomic Profiling of Bacterial Epigenetic Modifications. Biotechnology Journal, 2019, 14, 1800001. DOI: 10.1002/biot.201800001. 16.Yan G, Chen X, Du S, Deng Z, Wang L, Chen S*. Genetic mechanisms of arsenic detoxification and metabolism in bacteria. Current Genetics, 2019, 65: 329–338, doi.org/10.1007/s00294-018-0894-9. 17. Haotian Chi, Xiaoli Wang, Yue Shao, Ying Qin, Zixin Deng, Lianrong Wang, Shi Chen*. Engineering and modification of microbial chassis for systems and synthetic biology. Synthetic and Systems Biotechnology, 2019, 4: 25–3326. doi.org/10.1016/j.synbio.2018.12.001. 18. Chen S.*, Wang L., Deng Z*. Twenty years hunting for sulfur in DNA. Protein & Cell, 2010, 1(1): 14-21. 19. Wang L.#, Chen S.#, Xu T., Taghizadeh K., Wishnok J., Zhou X., You D., Deng Z, Dedon P. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology, 2007, 3(11): 709-710. 20. Chen S.#, Galan M. C.#, Carla Coltharp, O’Connor S. E. Redesign of a central enzyme in alkaloid biosynthesis. Chemistry & Biology, 2006, 13(11): 1137-41.