个人简历

学习经历： 2003/09-2009/06 武汉大学生命科学学院，病毒学方向，博士 (Wuhan University, PhD) 2005/08-2006/08 芬兰赫尔辛基大学，生物技术研究所，联合培养博士(University of Helsinki, Finland, Joint doctoral student) 1999/09-2003/06 武汉大学生命科学学院，生物技术系，本科 (Wuhan University, Bachelor's Degree) 主要工作经历与任职情况： 2011/11-至今， 武汉大学，生命科学学院，病毒学国家重点实验室，副教授 (College of Life Sciences, Wuhan University, Associate Prof.) 2015/9-2015/10，芬兰赫尔辛基大学，微生物系，访问学者 (University of Helsinki, Finland, visiting scholar) 2012/11-2013/01，2011/11-2012/01，2010/01-2010/03，芬兰赫尔辛基大学，生物技术研究所，访问学者 (University of Helsinki, Finland, visiting scholar) 2009/07-2011/10，武汉大学，生命科学学院，师资博士后（讲师） (College of Life Sciences, Wuhan University, lecturer)

研究领域

本实验室以冠状病毒（SARS-CoV，MERS-CoV）、艾滋病毒（HIV）及乙型肝炎病毒（HBV）为研究对象，通过解析病毒蛋白的结构功能关系，揭示病毒复制转录的机制，从而鉴定新的抗病毒药物靶点。在此研究的基础上筛选抗病毒先导化合物，同时利用基因治疗的手段开发抗病毒治疗新策略。

近期论文

1.Chen Yu*, Guo Deyin*, 2016. Molecular mechanisms of coronavirus RNA capping and methylation. Virologica Sinica, 31 (1): 3–11. 2.Li Shun, Zhu Mingzhu, Pan Ruangang, Fang Ting, Cao Yuanyuan, Chen Shuliang, Zhao Xiaolu, Lei Chaoqi, Guo Lin, Chen Yu, Li Chunmei, Jokitalo E, Yin Y, Shu Hongbing, Guo D*, 2016. The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nature Immunology, 17(3): 241-9. 3.Zeng Cong, Wu Andong, Wang Yi, Xu Shan, Tang Y, Jin Xu, Wang Shilei, Qin Lei, Sun Ying, Fan C, Snijder EJ, Neuman BW, Chen Yu, Ahola Tero, Guo Deyin*, 2016. Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales.Journal of Virology, JVI.00658-16. 4.Cui Lei, Wang Haiying, Ji Yanxi, Yang Jie, Xu Shan, Huang Xingyu, Wang Zidao, Qin Lei, Tien Po, Zhou Xi, Guo Deyin*, Chen Yu*, 2015. The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells. Journal of Virology, 89 (17): 9029-9043. 5.Wang Yi, Sun Ying, Wu Andong, Xu Shan, Pan Ruangang, Zeng Cong, Jin Xu, Ge Xinyi, Shi Zhengli, Ahola Tero, Chen Yu*, Guo Deyin*, 2015. Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. Journal of Virology, 89(16):8416-27. 6.Sun Ying, Wang Zidao, Tao Jiali, Wang Yi, Wu Aangdong, Yang Ziwen, Wang Kaimei, Shi Liqiao, Chen Yu* and Guo Deyin*, 2014. Yeast-based Assays for the High-throughput Screening of Inhibitors of Coronavirus RNA Cap Guanine-N7-methyltransferase. Antiviral Research, 14, 00036-9. 7.Liu Xing, Hao Ruidong, Chen Shuliang, Guo Deyin, Chen Yu*, 2015. Inhibition of Hepatitis B Virus by CRISPR/Cas9 System via Targeting the Conserved Regions of Viral Genome. Journal of General Virology, 96 (8): 2252-61. 8.Wu Andong, Wang Yi, Zeng Cong, Huang Xingyu, Xu Shan, Su Ceyang, Wang Min, Chen Yu*, Deyin Guo*, 2015. Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus. Virus Research, 208:56-65. 9.Chen Yu, Tao Jiali, Sun Ying, Wu Aangdong, Su Ceyang, Gao Guozhen, Cai Hui, Qiu Su, Wu Yingliang, Ahola Tero and Guo Deyin*, 2013. Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase. Journal of Virology, 87, 6296-305. 10.Chen Yu, Su Ceyang, Ke Min, Jin Xu, Xu Lirong, Zhang Zhou, Wu Angdong, Sun Ying, Yang Zhouning, Tien Po, Ahola Tero, Liang Yi, Liu Xinqi* and Guo Deyin*, 2011. Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. PLoS Pathogens, 7, e1002294. 11.Chen Yu, Cai Hui, Pan Ji'an, Xiang Nian, Tien Po, Ahola Tero and Guo Deyin*, 2009. Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proc Natl Acad Sci U S A, 106, 3484-9. 12.Hao Ruidong, He Jing, Liu Xing, Gao Guozhen, Liu Dan, Cui Lei, Yu Guojun, Yu Wenhui, Chen Yu, Guo Deyin*, 2015. Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6. Journal of Virology, 89, 4345-55. 13.Hou Panpan, Chen Shuliang, Wang Shilei, Yu Xiao, Chen Yu, Jiang Meng, Zhuang Ke, Ho Wenzhe, Hou Wei, Huang Jian, Guo Deyin*, 2015. Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Scientific Reports, 5:15577. 14.Yu Xiao, Chen Shuliang, Hou Pangpang, Wang Min, Chen Yu, Guo Deyin*, 2015. VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability. BBRC, 459(2): 270-276. 15.Jin Xu., Chen Yu., Sun Ying., Zeng Cong., Wang Yi., Tao Jiali., Wu Andong., Yu Xiao, Zhang Zhou, Tian Jie. and Guo Deyin*, 2013. Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP. Virus Research, 176, 45-52. 16.Ke Min#, Chen Yu#, Wu Angdong, Sun Ying, Su Ceyang, Wu Hao, Jin Xu, Tao Jiali, Wang Yi, Ma Xiao, Pan Ji'an and Guo Deyin*, 2012. Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2'-O-methyltransferase activity of nsp10/nsp16 complex. Virus Research, 167, 322-8. 17.Zhang Ke, Chen Yu, Pan Ji’an, Ahola Tero and Guo Deyin*, 2009. Lentiviral vector-derived shRNAs confer enhanced suppression of Semliki forest virus replication in BHK-21 cells compared to shRNAs expressed from plasmids. Biotechnol Lett. 31, 501-8. 18.Hussain, Snawa, Pan Ji’an, Chen Yu, Yang Yalin, Xu Jing, Peng Yu, Wu Ying, Li Zhaoyang, Zhu Ying, Tien Po. and Guo Deyin*, 2005. Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus.Journal of Virology, 79, 5288-95. 19.Li Zhaoyang, Xiong Yong, Peng Yu, Pan Ji’an, Chen Yu, Wu Xiaoyun, Hussain Snawa, Tien Po. and Guo Deyin*, 2005. Specific inhibition of HIV-1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis. FEBS Lett. 579, 3100-6.