个人简历

生于中国天津市，1990毕业于青岛海洋大学（中国海洋大学）生物学专业，1997年获得南开大学分子生物学硕士学位，2007年获得美国辛辛那提大学（University of Cincinnati）细胞和癌症生物学博士学位，部分研究成果发表于美国国家科学院院报（PNAS）。2008-09年任美国加州博尔诚公司细胞与分子生物学首席研究员，2009-12年担任美国辛辛那提儿童医院医学中心(Cincinnati Children’s Hospital Medical Center)博士后，2013-14任美国辛辛那提儿童医院医学中心研究员， 2014-16年任美国密西根波普医疗系统成人造血干细胞实验室研究员。 2016年-今任天津中医药大学中医药研究院研究员，天津市外籍高层次专家。此外，任Frontiers in Pharmacology 审稿人，担任美国辛辛那提儿童医院医学中心客座研究员，天津市抗衰老协会血液病专业委员会委员。在国际一流期刊发表学术论文20余篇，其中《PNAS》二篇,《Genes & Development》一篇,《Journal of Clinical Investigation》一篇，《Stem Cell Reports》一篇, 第一作者论文SCI 影响因子最高为9.5。2017年获得国家自然科学基金面上项目1项，2018年获天津市教委科研资助一项。2018年申请中国专利一项。

研究领域

中药及复方药理和毒理研究，中药免疫药理学，现代中药研发

近期论文

Lyu M, Zhou Z, Wang X, Lv H, Wang M, Pan G, Wang Y, Fan G, Gao X, Feng Y and Zhu Y (2018) Network Pharmacology-Guided Development of a Novel Integrative Regimen to Prevent Acute Graft-vs.-Host Disease. Front. Pharmacol. 9:1440. doi: 10.3389/fphar.2018.01440. IF=3.8
Liu H, He S, Wang T, Orang-Ojong B, Lu Q, Zhang Z, Pan L, Chai X, Wu H, Fan G, Zhang P, Feng Y, Song YS, Gao X, Karas RH, Zhu Y. Selected phytoestrogens distinguish roles of ERα transactivation and ligand binding for anti-inflammatory activity. Endocrinology. 2018 Jul 11. doi: 10.1210/en.2018-00275. [Epub ahead of print] PubMed PMID: 30010822.
Chadwick ML, Lane A, Thomas D, Smith AR, White AR, Davidson D, Feng Y, Boscolo E, Zheng Y, Adams DM, Gupta A, Veillette A, Chow LML. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget. 2018 May 15; 9(37):24750-24765. doi: 10.18632/oncotarget.25345. eCollection 2018 May 15. PubMed PMID: 29872503; PubMed Central PMCID: PMC5973867.
Chen X, Feng Y, Shen X, Pan G, Fan G, Gao X, Han J, Zhu Y. Anti-sepsis protection of Xuebijing injection is mediated by differential regulation of pro- and anti-inflammatory Th17 and T regulatory cells in a murine model of polymicrobial sepsis. J Ethnopharmacol. 2018 Jan 30; 211:358-365. doi:10.1016/j.jep.2017.10.001. Epub 2017 Oct 4. PubMed PMID: 28987599. IF=3
Liu M, Zhang Z, Sampson L, Zhou X, Nalapareddy K, Feng Y, Akunuru S, Melendez J, Davis AK, Bi F, Geiger H, Xin M, Zheng Y. RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Stem Cell Reports. 2017 Dec 12; 9(6):1961-1975. doi: 10.1016/j.stemcr.2017.10.004. Epub 2017 Nov 9. PubMed PMID: 29129684; PubMed Central PMCID: PMC5785633.
Xiao M, Yang J, Feng Y, Zhu Y, Chai X, Wang Y. Metaproteomic strategies and applications for gut microbial research. Appl Microbiol Biotechnol. 2017 Mar 14. doi: 10.1007/s00253-017-8215-7. [Epub ahead of print] Review. PubMed PMID: 28293710.
Al-Homsi AS, Goodyke A, McLane M, Abdel-Mageed S, Cole K, Muilenburg M, Feng Y. Post-Transplantation Cyclophosphamide and Ixazomib Combination Rescues Mice Subjected to Experimental Graft-versus-Host Disease and Is Superior to Either Agent Alone. Biol Blood Marrow Transplant. 2017 Feb; 23(2):255-261. doi:10.1016/j.bbmt.2016.11.015. PubMed PMID: 27888016.
Al-Homsi AS, Goodyke A, Cole K, Muilenburg M, McLane M, Abdel-Mageed S, Feng Y. Ixazomib Suppresses Human Dendritic Cell and Modulates Murine Graft-Versus-Host Disease in a Schedule-Dependent Fashion. Exp Hematol. 2016 Dec 19. pii: S0301-472X(16)30770-6. doi: 10.1016/j.exphem.2016.12.002. [Epub ahead of print] PubMed PMID: 28007655.
Al-Homsi AS, Feng Y, Duffner U, Al Malki MM, Goodyke A, Cole K, Muilenburg M, Abdel-Mageed A. Bortezomib for the prevention and treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Exp Hematol. 2016 Sep; 44(9):771-7. doi: 10.1016/j.exphem.2016.05.005. Review. PubMed PMID: 27224851.
Al-Homsi AS, Roy TS, Cole K, Feng Y, Duffner U. Post-transplant high-dose cyclophosphamide for the prevention of graft-versus-host disease. Biol Blood Marrow Transplant. 2015 Apr; 21(4):604-11. doi: 10.1016/j.bbmt.2014.08.014. Epub 2014 Aug 23. Review. PubMed PMID: 25240817
Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F, Wang C, Yang Y, Hinton A Jr, Yan C, Ding H, Zhu L, Yu L, Yang B, Feng Y, Clegg DJ, Khan S, DiMarchi R, Mani SK, Tong Q, Xu Y. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. J Clin Invest. 2014 Aug 26. pii: 74726. doi:10.1172/JCI74726. [Epub ahead of print] PubMed PMID: 25157819.
Feng Y and Zheng Y. Oncogenic Insult In Bone Marrow Endothelial Cells Causes Hematopoietic Abnormalities. November 15, 2013; Blood: 122 (21): 2461
Feng Y, Singleton DW, Guo C, Gardner A, Pakala S, Kumar R, Jensen EV, Zhang J and Khan SA. DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor. PlosOne July 2013. http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068075
Feng Y, Zou X, Liu W, Guo F, Liu M, Sampson L, You L-R, Kuan C-Y and Zheng Y. Rho Gtpase Cdc42 Is Essential for Endothelial Niche Maintenance in the Bone Marrow and Hematopoiesis. Blood (ASH Annual Meeting Abstracts), Nov 2012; 120 (21): 508.
Feng Y, Liu M, Guo F, Liu W, Sampson L, You L-R, Kuan C-Y and Zheng Y. Novel Method to Study Mouse Bone Marrow Endothelial Cells in Vivo and in Vitro. Blood. Nov 2012; 120 (21): 617.
Sipes NS, Feng Y, Guo F, Lee HO, Chou FS, Cheng J, Mulloy J, Zheng Y. Cdc42 regulates extracellular matrix remodeling in three dimensions. J Biol Chem. 2011 Oct 21; 286 (42):36469-77.
Feng Y, Zhou X and Zheng Y. The Rho GTPase Cdc42 Is a Key Regulator of the Genesis and Function of Bone Marrow Derived Endothelial-Like Cells. Blood. Nov 2010; 116 (21): 2109.
Liu W, Feng Y, Shang X, Zheng Y. Rho GTPases in hematopoietic stem/progenitor cell migration. Methods Mol Biol. 2011; 750:307-19.
Feng Y, Manka D, Wagner KU, Khan SA. Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14718-23.
Singleton DW, Feng Y, Yang J, Puga A, Lee AV, Khan SA. Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environ Res. 2006 Jan; 100(1):86-92.