个人简历

教育背景
2006.09-2011.06 于南开大学读五年制博士研究生(免试保送), 生物化学及分子生物学专业，获理学博士学位
2008.09-2009.04 德国海德堡德国癌症研究中心(DKFZ)研修
2002.09-2006.06 于南开大学读本科(免试保送), 生命科学专业, 获学士学位
工作经历
2018.11-至今 天津医科大学 生物化学与分子生物学 教授
2013.10-2018.11 天津医科大学 生物化学与分子生物学 副教授
2011.07-2013.10 天津医科大学 生物化学与分子生物学 讲师

研究领域

肿瘤分子生物学

近期论文

Yu L#, Shi JD, Wang CY, Klocker H, Mayer D, Zhang J*. Estradiol promotes the invasive potency of prostate cancer cells in a paracrine manner through stimulation of prostatic stromal cells. The Journal of Urology,2010, 183(4): e267. (IF: 4.016)
Yu L#, Wang CY, Shi JD, Du XL, Mayer D *, Zhang J*: Estrogen promotes invasion of prostate cancer cells in a paracrine manner through upregulation of matrix metalloproteinase 2 in prostatic stromal cells. Endocrinology, 2011, 152(3):773-781. (IF: 4.752)
Yu L#, Shi J, Cheng S, Zhu Y, Zhao X, Yang K, Du X, Klocker H, Yang X, Zhang J*: Estrogen promotes prostate cancer cell migration via paracrine release of ENO1 from stromal cells. Mol Endocrinol. 2012 Sep;26(9):1521-30. (IF: 4.993)
Li Y, Wang Y, Yu L#, Sun C, Cheng D, Yu S*, Wang Q, Yan Y, Kang C, Jin S, An T, Shi C, Xu J, Wei C, Liu J, Sun J, Wen Y, Zhao S, Kong Y. miR-146b-5p inhibits glioma migration and invasion by targeting MMP16. Cancer Lett. 2013 Oct 10;339(2):260-9. (IF: 5.012)
Wang Y, Li Y, Sun J, Wang Q, Sun C, Yan Y, Yu L, Cheng D, An T, Shi C, Xu J, Wei C, Liu J, Wen Y, Zhao S, Li H, Zhang H, Xu H, Yu S*. Tumor-suppressive effects of miR-29c on gliomas. Neuroreport. 2013 Aug 21;24(12):637-45. (IF: 1.644)
Xu H, Sun J, Shi C, Sun C, Yu L, Wen Y, Zhao S, Liu J, Xu J, Li H, An T, Zhou X, Ren L, Wang Q, Yu S*. miR-29s inhibit the malignant behavior of U87MG glioblastoma cell line by targeting DNMT3A and 3B. Neurosci Lett. 2015 Mar 17;590:40-6. (IF: 2.055)
Yu L#, Liu X, Cui K, Di Y, Xin L, Sun X, Zhang W, Yang X, Wei M, Yao Z, Yang J*. SND1 Acts Downstream of TGFβ1 and Upstream of Smurf1 to Promote Breast Cancer Metastasis. Cancer Res. 2015 Apr 1;75(7):1275-86. (IF: 9.284)
Yu L#, Di Y, Xin L, Ren Y, Liu X, Sun X, Zhang W, Yao Z, Yang J*. SND1 acts as a novel gene transcription activator recognizing the conserved Motif domains of Smad promoters, inducing TGFβ1 response and breast cancer metastasis. Oncogene. 2017 Jul 6;36(27):3903-3914. (IF: 7.529)
Li H, Yu L#, Liu J, Bian X, Shi C, Sun C, Zhou X, Wen Y, Hua D, Zhao S, Ren L, An T, Luo W, Wang Q, Yu S*. miR-320a functions as a suppressor for gliomas by targeting SND1 and β-catenin, and predicts the prognosis of patients.Oncotarget. 2017 Mar 21;8(12):19723-19737. (IF: 5.168)
Liu J, Yang J, Yu L#, Rao C, Wang Q, Sun C, Shi C, Hua D, Zhou X, Luo W, Wang R, Li W, Yu S*. miR-361-5p inhibits glioma migration and invasion by targeting SND1.Onco Targets Ther. 2018 Aug 28;11:5239-5252 (IF: 2.656)
Zhang S, Zhang H, Yu L*. HMGA2 promotes glioma invasion and poor prognosis via a long-range chromatin interaction. Cancer Med. 2018 Jul; 7(7): 3226–3239. (IF: 3.202)
Yu L#, Xu J, Liu J, Zhang H, Sun C, Wang Q, Shi C, Zhou X, Hua D, Luo W, Bian X, Yu S*. The novel chromatin architectural regulator SND1 promotes glioma proliferation and invasion and predicts the prognosis of patients.Neuro Oncol. 2019 Jun 10;21(6):742-754. (IF: 10.091)
Zhang S, Gao M, Yu L*. GATAD1 gene amplification promotes glioma malignancy by directly regulating CCND1 transcription.Cancer Med. 2019 Jul 8. [Epub ahead of print](IF: 3.357)