个人简历

教育背景
2003.09-2008.07 博士 生物化学与分子生物学 北京大学医学部
1998.09-2003.07 医学学士 基础医学专业 北京大学医学部
工作经历
2015.10至今 研究生院副院长 天津医科大学
2015.03至今 生物化学与分子生物学系系副主任 教授 天津医科大学
2008.08-2014.12　博士后 美国Salk生物研究所

研究领域

基因表达调控

近期论文

1.Sun Y#, Liu Z#, Cao X#, Lu Y, Mi Z, He C, Liu J, Zheng Z, Li MJ, Li T, Xu D, Wu M, Cao Y, Li Y, Yang B, Mei C*, Zhang L*, Chen Y*. Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. Sci Adv. 2019 Jun 5;5(6):eaaw3593. (#equal contribution)
2.Cao X#, Dang L#, Zheng X#, Lu Y, Lu Y, Ji R, Zhang T, Ruan X, Zhi J, Hou X, Yi X, Li MJ, Gu T, Gao M*, Zhang L*, Chen Y*. Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma. Thyroid. 2019 Jun;29(6):809-823. (#equal contribution)
3.Chen, Y#., Zhang, L.#, Estarás, C., Choi, S., Moreno, L., Karn, J., Moresco, J.J., Yates J.R., and Jones, K.A.* 2014. A Gene-specific Role for Ssu72 RNAPII CTD Phosphatase in HIV-1 Tat Transactivation. Genes Dev. 28(20):2261-2275 (#equal contribution).
4.Chen, Y.#, Zhang, L., and Jones, K.A.* 2011. SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing. Genes Dev. 25(7):701-16.
5.Wang, Y., Zhang, H., Chen, Y., Sun, Y., Yang, F., Yu, W., Liang, J., Sun, L., Yang, X., Shi, L., Li, R., Li, Y., Zhang, Y., Li, Q., Yi, X., and Shang, Y*. 2009. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell. 138(4): 660-672.
6.Li, R., Zhang, H., Yu, W., Chen, Y., Gui, B., Liang, J., Wang, Y., Sun, L., Yang, X., Zhang, Y., Shi, L., Li, Y., and Shang, Y*. 2009. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28(18): 2763-2776.
7.Chen, Y.#, Shi, L., Zhang, L., Li, R., Liang, J., Yu, W., Sun, L., Yang, X., Wang, Y., Zhang, Y., and Shang, Y*. 2008. The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem. 283(26): 17969-17978.
8.Shi, B., Liang, J., Yang, X., Wang, Y., Zhao, Y., Wu, H., Sun, L., Zhang, Y., Chen, Y., Li, R., Hong, M., and Shang, Y*. 2007. Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. Mol Cell Biol. 27(14): 5105-5119.
9.Fan, D., Chen, Z., Chen, Y., and Shang, Y*. 2007. Mechanistic roles of leptin in osteogenic stimulation in thoracic ligament flavum cells. J Biol Chem. 282(41): 29958-29966.
10.Zhang, H., Sun, L., Liang, J., Yu, W., Zhang, Y., Wang, Y., Chen, Y., Li, R., Sun, X., and Shang, Y*. 2006. The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. EMBO J. 25(18): 4223-4233.
11.Wu, H., Sun, L., Zhang, Y., Chen, Y., Shi, B., Li, R., Wang, Y., Liang, J., Fan, D., Wu, G., Wang, D., Li, S., and Shang, Y*. 2006. Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylation. J Biol Chem. 281(31): 21848-21856.
12.Wu, H., Chen, Y., Liang, J., Shi, B., Wu, G., Zhang, Y., Wang, D., Li, R., Yi, X., Zhang, H., Sun, L., and Shang, Y*. 2005. Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature. 438(7070): 981-987.
天津市细胞生物学会理事
中国药理学会肾脏委员会常委