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马龙
2023-05-13 11:25
  • 马龙
  • 马龙 - -天津科技大学-生物工程学院-个人资料

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资料介绍

个人简历


马龙,男,1983年生,教授,博导。先后主持和参加了多个中国、英国和欧盟的科研基金项目,总额大于210万英镑。回国后主持国家自然基金青年、面上项目等。2014年5月入职天津科大任副教授,2015年10月起任教授,2017年任博士生导师。
近年先后发表31篇SCI文章,其中26篇发表于JCRI、II区杂志。文章总影响因子约150,影响因子>5分8篇,其中第一作者/通讯作者6篇。影响因子>9分4篇,其中第一作者3篇。单篇文章最高影响因子11.4,单篇第一作者文章最高被SCI引用67次。发表的文章曾被国际著名期刊Chem.Rev.(IF=45.6),Nat.Nanotechnol.(IF=33.3),Acc.Chem.Res.(IF=24.3)等引用。文章被2012年4月11日出版的美国化学会志(IF=11.4)作为封面进行报道。2014年发表在ChemBioChem的文章被当年2月3日出版的美国化学会著名的科学传播杂志《化学和工程新闻》(C&ENews)作为“亮点”报道;并被评选为ChemBioChem杂志(JCR二区)“Most-accessedarticlespublishedinChemBioChemduring2015”。2014年发表在JournalofEthnopharmacology的药理学文章被美国医生网MDLinx作为“推荐”文章报道。现申请中国专利4项。
获得中国国家留学基金委奖学金(CSCscholarship),英国爱丁堡大学MTEM科研奖励,英国爱丁堡大学化学院奖学金,英国爱丁堡大学会议奖学金(conferencegrant),欧洲科学研究委员会博士后研究基金奖励等。多次参加国际核酸生物和化学年会、英国皇家化学会组织的学术研讨会,并在大会上做口头及墙报展示。
教育及工作背景:
2002.09-2006.07天津医科大学药剂学学士(Bsc)
2006.09-2008.07天津大学药物科学与技术学院药剂学硕士(Msc)
2008.09-2011.11英国爱丁堡大学生物物理化学博士(PhD)
2011.11-2014.04英国圣安德鲁斯大学生物医学研究中心研究员(ResearchFellow)
主讲课程:
本科生:分子生物学;微生物遗传学与育种(双语)
研究生:制药工程专题讲座;新药研究与开发;科技论文写作等
所获奖励:
2008年国家留学基金委CSC奖学金
2008年英国爱丁堡大学MTEM奖学金
2008年爱丁堡大学化学院奖学金
2012年欧洲研究理事会ERC博士后基金
2014年天津科技大学“海河学者”培育计划
2016年天津市创新人才推进计划“青年科技优秀人才”
2016年天津市创新人才推进计划“重点领域创新团队”(参与)
2017年度天津市创新创业创优先进个人
2017年度入选天津市高校“中青年骨干创新人才培养计划”

研究领域


1.基于核酸、核酸相关酶、核酸适体和纳米材料的生物传感器研究,用于生物样品的分析和药品、食品质量控制。
2.基于天然活性产物的抗肿瘤、抗炎活性物质发现及药理学评价;靶向人类核酸修复系统抑制剂的发现和抗肿瘤活性评价。
3.链霉菌中的生物催化、生物合成及代谢研究。新型生物催化剂(酶)的发现、设计和利用;生物催化路线和次级活性代谢产物生物合成途径的研究;链霉菌中活性天然的发现。

近期论文


1.LongMaandScottL.Cockroft*Biologicalnanoporesforsingle-moleculebiophysics.ChemBioChem,2010,11,25-34.(IF=3.945,JCR二区)
2.CraigP.Wilson,CécileBoglio,LongMa,ScottL.CockroftandSimonJ.Webb*Palladium(II)-mediatedassemblyofbiotinylatedionchannels.Chemistry−AEuropeanJournal,2011,17,3465-3473.(IF=5.476,JCR二区)
3.TaraSabir,AnitaToulmin,LongMa,AnitaC.Jones,PeterMcGlynn,GunnarF.Schroder*andStevenW.Magennis*Branchpointexpansioninafullycomplementarythree-wayDNAjunction.JournaloftheAmericanChemicalSociety,2012,134,6280-6285.(IF=11.336,JCR一区)“featuredascoverart”(被选为封面报道)
4.LongMa,KaiChen,DavidJ.Clarke,ChristopherP.Nortcliffe,GeoffreyG.Wilson,J.MichaelEdwardson,A.JenniferMorton,AnitaC.JonesandDavidT.F.Dryden*RestrictionendonucleaseTseIcleavesA:AandT:TmismatchesinCAGandCTGrepeats.NucleicAcidsResearch,2013,41,4999-5009.(IF=9.202,JCR一区)
5.L.DavidFinger#,NikeshPatel#,AmandaBeddows#,LongMa#(共同第一作者),JackC.Exell#,EmmaJardine,AnitaC.Jones*andJaneA.Grasby*ObservationofunpairedsubstrateDNAintheflapendonuclease-1activesite.NucleicAcidsResearch,2013,41,9839-9847.(IF=9.202,JCR一区)
6.LongMa,XiaohuaWu,GeoffreyG.Wilson,AnitaC.JonesandDavidT.F.Dryden*Time-resolvedfluorescenceof2-aminopurineinDNAduplexesinthepresenceoftheEcoP15ITypeIIIrestriction-modificationenzyme.BiochemicalandBiophysicalResearchCommunications,2014,449,120-125.(IF=2.281,JCR二区)
7.HaiDeng,*#LongMa#(共同第一作者),NouchaliBandaranayaka,ZhiweiQin,GregMann,KwakuKyeremeh,YiYu,ThomasShepherd,JamesH.NaismithandDavidO’Hagan*IdentificationoffluorinasesfromStreptomycessp.MA37,Norcardiabrasiliensis,andActinoplanessp.N902-109bygenomemining.ChemBioChem,2014,15,364-368.(IF=3.945,JCR二区)“highlightedinACSC&ENews,Volume92Issue5,Feb3,2014,p.25-26”被美国化学会化学与工程新闻作为“重点”报道;被评选为ChemBioChem杂志“Most-accessedarticlespublishedinChemBioChemduring2015”。
8.ShengHuang#,LongMa#(共同第一作者),MingHimTong,YiYu,*DavidO’HaganandHaiDeng*Fluoroacetatebiosynthesisfromthemarine-derivedbacteriumStreptomycesxinghaiensisNRRLB-24674.Organic&BiomolecularChemistry,2014,12,4828-4831.(IF=3.487,JCR二区)
9.LongMa*andJiangguangLiuTheprotectiveactivityofConyzabliniisaponinagainstacutegastriculcerinducedbyethanol.JournalofEthnopharmacology,2014,158,PartA,358-363.(IF=2.939,*通讯作者,JCR二区)“featuredinMDLinx.com”被美国医生网MDLinx作为“推荐”文章报道。
10.LongMa,AxelBartholome,MingHimTong,ZhiweiQin,YiYu,ThomasShepherd,KwakuKyeremeh,HaiDeng*andDavidO’Hagan*IdentificationofafluorometabolitefromStreptomycessp.MA37:(2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoicacid.ChemicalScience,2015,6,1414-1419.(IF=9.211,JCR一区)
11.LongMa*,andAipoDiaoMarizomib,Apotentsecondgenerationproteasomeinhibitorfromnaturalorigin.Anti-cancerAgentsinMedicinalChemistry,2015,15,298-306.(IF=2.939,*通讯作者,JCR二区)
12.LongMa*,andAipoDiaoDesignenzyme-interfacedDNAlogicoperations(AND,ORandINHIBIT)withanassayingapplicationforsingle-basemismatch.ChemicalCommunications,2015,51,10233-10235.(IF=6.834,*通讯作者,JCR一区)
13.LongMa*,GuanrongWu,YufengLi,PingQin,LingpeiMeng,HaiyanLiu,YuyinLiandAipoDiaoAreversiblemetalionsfueledDNAmoleculardevicefor“turn-onand-off”fluorescencedetectionofmercuryions(II)andbiothiolsrespectivelywithhighselectivityandsensitivity.Nanoscale,2015,7,18044-18048.(IF=7.760,*通讯作者,JCR一区)
14.LongMa*,YufengLi,LingpeiMeng,HaiDeng,YuyinLi,QiangZhangandAipoDiaoBiologicalfluorinationfromthesea:DiscoveryofaSAM-dependentnucleophilicfluorinatingenzymefromthemarine-derivedbacteriumStreptomycesxinghaiensisNRRLB24674.RSCAdvances,2016,6,27047-27051.(IF=3.840,*通讯作者,JCR二区)
15.LongMa*,HaiyanLiu,GuanrongWu,NanaSun,LingpeiMeng,YuyinLi,ZhenxingLiuandAipoDiaoAdual-channeldetectionofmercuricionsusingalabelfreeG-quadruplex-basedDNAzymemolecule.Analyst,2016,141,3997-4000.(IF=4.107,*通讯作者,JCR一区)
16.JingLiua,ShuliMan,ZhenLiu,LongMa,WenyuanGaoAsynergisticantitumoreffectofpolyphyllinIandformosaninConhepatocarcinomacells.Bioorganic&MedicinalChemistryLetters,2016,26,4970-4975.(IF=2.486,JCR三区)
17.Curcumin-cyclodextrincomplexesenhancedtheanti-cancereffectsofcurcumin.EnvironmentalToxicologyandPharmacology,2016,48,31-38.(IF=2.187,JCR三区)
18.Inhibitionofurethane-inducedlungcarcinogenesisinmicebyaRhizomaparidissaponininvolvedEGFR/PI3K/Aktpathway.RSCAdvances,2016,6,92330-92334.(IF=3.289,JCR二区)
19.LongMa*,HaiyanLiu,LingpeiMeng,PingQin,BotaoZhang,YuyinLi,ShuliMan,ZhenLiu,ZhenxingLiuandAipoDiaoEvaluationoftheanti-canceractivityofthetriterpenoidalsaponinfractionisolatedfromthetraditionalChinesemedicineConyzabliniiH.Lév.RSCAdvances,2017,7,3408-3412.(IF=3.289,*通讯作者,JCR二区)
20.MetabolicregulatorynetworkalterationsrevealsdifferenttherapeuticeffectsofcisplatinandRhizomaparidissaponinsinLewispulmonaryadenomamice.RSCAdvances,2016,6,115029-115038.(IF=3.289,*通讯作者,JCR二区)
21.LysosomeinhibitorsenhancethechemotherapeuticactivityofDoxorubicininHepG2cells.Chemotherapy,2016,62,85-93.(IF=0.992,JCR四区)
22.Sp1transcriptionfactorpromotesTMEPAIgeneexpressionandcontributestocellproliferation.CellProliferation,2016,49,710-719.(IF=3.084,JCR三区)
23.LongMa*,HaiyanLiu,PingQing,ChenxiHu,ShuliMan,YuyinLi,ZhenLiu,ZhenxingLiu,AipoDiaoSaponinfractionisolatedfromConyzabliniiH.Lév.demonstratesstronganti-canceractivitythatisduetoitsNF-κBinhibition.BiochemicalandBiophysicalResearchCommunications,2017,483,779-785.(IF=2.371,*通讯作者,JCR二区)
24.Inhibitionoflungcancerindiethylnitrosamine-inducedmicebyRhizomaparidissaponins.MolecularCarcinogenesis,2017,56,1405–1413.(IF=4.722,JCR二区)
25.CurcuminAttenuatesN-Nitrosodiethylamine-Inducedliverinjuryinmicebyutilizingthemethodofmetabonomics.JournalofAgricultureandFoodChemistry,2017,65,2000-2007.(IF=3.154,JCR一区)
26.HaiyanLiu,ChenxiHu,NanaSun,YuyinLi,ShuliMan,ZhenxingLiu,AipoDiaoandLongMa*AtriterpenoidalsaponinfractionofConyzabliniiH.Lév.isadual-targetingautophagyinhibitorforHeLacells.RSCAdvances,2017,7,24291-24297.(IF=3.289,*通讯作者,JCR二区)
27.LongMa*,NanaSun,ChunhaoTu,QianZhang,AipoDiao*Designanaptamer-basedfluorescencedisplacementbiosensorforselectiveandsensitivedetectionofkanamycininaqueous-samples.RSCAdvances,2017,7,38512-38518.(IF=3.289,*通讯作者,JCR二区)
28.ShuliMan,JiangMa,JingwenYao,JingxiaCui,ChunxiaWang,YuLi,LongMa*,andFupingLu*SystemicperturbationsofkeymetabolitesinType2diabeticratstreatedbypolyphenolsextractsfromLitchichinensisseeds.JournalofAgricultureandFoodChemistry,2017,65,7698–7704.(IF=3.154,JCR一区)
29.LowdensitylipoproteinreceptorclassAdomaincontaining4(LDLRAD4)promotestumorigenesisofhepaticcancercells.ExperimentalCellResearch,2017,360,189-198.(IF=3.546,JCR二区)
30.Antitumorandanti-metastaticmechanismsofRhizomaparidissaponinsinLewismice.EnvironmentalToxicology,2017,accepted.(IF=2.937,JCR二区)
31.LongMa,*NanaSun,JinyanZhang,ChunhaoTu,XiuqiCao,DeminDuan,AipoDiao*,ShuliMan*Polyethylenimine-coatedFe3O4nanoparticleseffectivelyquenchfluorescentDNA,whichcanbedevelopedasanovelplatformforproteindetection.Nanoscale,2017,9,17699-17703.(IF=7.760,*通讯作者,JCR一区)
应邀作为BMCMol.Bio.,Curr.CancerDrugTar.,ChemBioChem,AnticancerAgentsMed.Chem.,Inflammation,BMCComplementAltern.Med.,Pharmacogn.Mag.,RSCAdvances等数十种著名专业期刊的审稿人;2015年收到CurrentMedicinalChemistry(JCR二区,IF=3.853)特约编辑邀请;
《TraditionalMedicineResearch》杂志编委;
中国微生物学会会员;
天津市药学会会员,天津市药学会青委会委员;
天津市科委、河北省科委项目评审专家等。

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