刁爱坡
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资料介绍
个人简历
刁爱坡,博士,天津市特聘教授,硕士生和博士生导师。2001年获英国TheUniversityofHertfordshire博士学位,2001-2008年英国曼彻斯特大学生命科学学院博士后,2009年任天津科技大学生物工程学院教授。入选教育部新世纪优秀人才支持计划,主持国家自然科学基金,天津市自然科学基金等科研项目。主讲课程本科生:分子生物学,基因工程药物研究生:分子生物学,基因工程制药申请专利:[1]刁爱坡,李玉银,郁彭,宋宁,王啊丽。一种吲哚酮类化合物的新用途。2018101008225[2]刁爱坡,李玉银,郁彭,赵苗苗,陈月,李丙旭。一种苯甲酸酯类化合物及其制备方法与应用。2017113456980[3]刁爱坡,李玉银,郁彭,刘阳,李志鹏。一种吲哚酮类化合物及其制备方法与应用。2017114061733研究领域
[1]寻找新型药物靶点,筛选具有抗肿瘤、炎症、衰老药物与分子药理学研究[2]利用微生物发酵和细胞培养技术表达和制备基因工程蛋白质药物近期论文
[1]LiY,WangJ,SongN,ZengF,ZhaoM,WangA,ChenY,JingL,YuP,DiaoA*.2-(2-nitrobenzylidene)indolin-3-onecompoundinhibitstransmembraneprostateandrogen-inducedprotein(TMEPAI)expressionandcancercellproliferation.CellProlif.2018,51(5):e12469.[2]TianZhao,ZhipengLi,ZhouliangGuo,AliWang,ZhenxingLiu,QingZhao,YuyinLi,EdwardA.McKenzie,AipoDiao*.FunctionalrecombinanthumanLegumainproteinexpressioninPichiapastoristoenablescreeningforLegumainsmallmoleculeinhibitors.ProteinExpressionandPurification.2018,150:12-16.[3]YuyinLi,GuojunPan,YueChen,QianYang,TiantianHao,LianboZhao,LongZhao,YushengCong,AipoDiao*,PengYu*.Inhibitorofthehumantelomerasereversetrancriptase(hTERT)genepromoterinducescellapoptosisviaamitochondrial-dependentpathway.EuropeanJournalofMedicinalChemistry.2017145:370-378[4]LiuZ,HuoX,ZhaoS,YangJ,ShiW,JingL,LiW,LiY,MaL,GaoY,DiaoA*.LowdensitylipoproteinreceptorclassAdomaincontaining4(LDLRAD4)promotestumorigenesisofhepaticcancercells.ExpCellRes.20176:30475-5.[5]ShenhengLuo,LeiJing,TianZhao,YuyinLi,ZhenxingLiu,AipoDiao*.UbiquitinationanddynactinregulateTMEPAIlysosomaltrafficking.SciRep.20177:42668.[6]YuyinLi,AilongGuo,JianjunWang,YaliYan,LeiJing,ShenhengLuo,XingNiu,LifangJing,BoJiang,MengYang,ZhenxingLiu,LongMa,AipoDiao*.Sp1transcriptionfactorspromoteTMEPAIgeneexpressionandcontributetotumorigenesis.CellProliferation201649(6):710-719.[7]YuyinLi,YuejunSun,LifangJing,JianjunWang,YaliYan,YajuanFeng,YueyingZhang,ZhenxingLiu,LongMa,AipoDiao*.LysosomeinhibitorsenhancethechemotherapeuticactivityofdoxorubicininHepG2cells.Chemotherapy201662(2):85-93.[8]LuoS1,YangM1,LvD1,JingL1,LiY1,LiuZ1,DiaoA*.TMEPAIincreaseslysosomestabilityandpromotesautophagy.IntJBiochemCellBiol.201676:98-106.[9]YuyinLi,LiZhang,JieZhou,ShenhengLuo,RuiHuang,ChangcaiZhaoandAipoDiao*.Nedd4E3ubiquitinligasepromotescellproliferationandautophagy.CellProliferation201548(3):338-347.[10]JianliDang,LeiJing,WeiweiShi,PingQin,YuyinLi,AipoDiao*.Expressionandpurificationofactiverecombinanthumanbonemorphogenetic7-2dimerfusionprotein.ProteinExpressionandPurification2015115:61-68.[11]XilongBai,LeiJing,YinchuanLi,YuyinLi,ShenhengLuo,ShashaWang,JieZhou,ZheLiu,AipoDiao*.TMEPAIinhibitsTGF-βsignalingbypromotinglysosomedegradationofTGF-βreceptorandcontributestolungcancerdevelopment.CellularSignalling201426:2030-2039.[12]KouKunyuan,DangJianli,ZhangBaoxia,WuGuanrong,LiYuyin,DiaoAipo*.EstablishmentofamethodtomeasuretheinteractionbetweenNedd4andUbCH5cfordrugscreening.Proceedingsofthe2014InternationalConferenceonAppliedBiotechnology.[13]AipoDiao,LauraFrost,YuichiMorohashiandMartinLowe.CoordinationofgolgintetheringandSNAREassembly:GM130bindssyntaxin5inap115-regulatedmanner.JournalofBiologicalChemistry.2008283(11):6957-67.[14]Chi-FangChiu,YashodaGhanekar,LauraFrost,AipoDiao,DanielMorrison,EdwardMcKenzieandMartinLowe.ZFPL1,anovelringfingerproteinrequiredforcis-GolgiintegrityandefficientERtoGolgitransport.EMBOJournal200827(7):934-47.[15]NooraHyvola,AipoDiao,EddieMckenzie,AlisonSkippen,ShamshadCockcroftandMartinLowe.MembranetargetingandactivationoftheLowesyndromeproteinOCRL1byrab1GTPases.EMBOJournal200625(16):3750-61.[16]Choudhury,R.,Diao,A.,Zhang,F.,Eisenberg,E.,Saint-Pol,A.,Williams,C.,Konstantakopoulos,A.,Lucocq,J.,Johannes,L.,Rabouille,C.,Greene,L.andLowe,M.LowesyndromeproteinOCRL1interactswithclathrinandregulatesproteintraffickingbetweenendosomesandthetrans-Golginetwork.MolecularBiologyoftheCell200816(8):3467-79.[17]Diao,A.andLowe,M.TheGolgigoesfission.Science2004305,48-49.[18]Diao,A.,Rahman,D.,Pappin,D.J.C.,Lucocq,J.andLowe,M.Thecoiled-coilmembraneproteingolgin-84isanovelrabeffectorrequiredforGolgiribbonformation.JournalofCellBiology2003160,201-212. 相关热点
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