个人简历

美国癌症协会（AACR）会员 ；Mayo Clinic Research Fellow’s Association（梅奥医院研究学者联合会会员）；International Journal of Biological Sciences杂志审稿人 ；Nucleic Acids Research 杂志审稿人

研究领域

致力于DNA损伤与肿瘤发生相关性研究。工作重点集中在DNA损伤诱导肿瘤相关重要因子去泛素化及去乙酰化修饰与肿瘤发生信号调控网络相关性研究

近期论文

1. Yuan J（袁健）, Luo K, Zhang L, Cheville J , Lou Z. USP10 Regulates p53 Localization and Stability by Deubiquitinating p53. Cell 2010 Feb 5;140(3):384-96. (Highlighted by Cell. 2010 Feb 5;140(3):308-10.) (IF=31.253) 2. Yuan J（袁健）*, Luo K,tongzheng Liu, Lou Z*. Regulation of SIRT1 activity by genotoxic stress. Genes&Development 2012 Apr 15;26(8):791-6. (IF=12.889) （共同通讯作者及第一作者） 3. Luo K, Zhang H, Wang L, Yuan J（袁健）*, Lou Z*. Sumoylation of MDC1 is important for proper DNA damage response. EMBO J 2012 May 25. doi: 10.1038/emboj.2012.158. (IF=10.124) （共同通讯作者） 4. Yuan J（袁健）, Minter-Dykhouse K, Lou Z. A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol. 2009 Apr 20;185(2):203-11. (Highlighted by J Cell Biol. 2009 Apr 20;185(2):203-11. and reported by The BCN (Breast Cancer.Net) News 23 Apr 2009) (IF=9.12) 5. Luo K, Yuan J（袁健）, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol. 2009 Feb;11(2):204-10. (IF=17.774） 6. Yuan J（袁健）, Pu M, Zhang Z, Lou Z. Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle. 2009 Jun 1;8(11):1747-53. (IF=4.12) 7. Luo K, Yuan J（袁健）, Lou Z. Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response. J Biol Chem. 2011 Aug 12;286(32):28192-9.（并列第一作者）(IF=5.328) 8. Yuan J（袁健）, Tang W, Luo K, Chen X, Gu X, Wan B, Yu L. Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53. Mol Biol Rep. 2006 Sep; 33(3): 151-8. 9. Yuan J（袁健）, Shan Y, Chen X, Tang W, Luo K, Ni J, Wan B, Yu L. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Mol Biol Rep. 2005 Dec;32(4):205-14. 10. Tang W, Yuan J（袁健）, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L. Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. J Biochem Mol Biol. 2006 Sep; 39(5):626-35. 11. Guo Z, Yuan J（袁健）, Tang W, Chen X, Gu X, Luo K, Wang Y, Wan B, Wang Y, Yu L. Cloning and Characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. Mol Biol Rep. 2007 Sep; 34(3):137-44. (并列第一作者)