个人简历

2005-现今 天津大学管理学院 博士导师\r
2001-现今 天津大学药物科学与技术学院 博士导师\r
2001-2013 天津大学药物科学与技术学院院长\r
2001-03 天津TEDA开发区 科技局与技术监督局局长\r
1999-01 功能基因研究院 首席科学家（Novartis研究基金会）\r
1995-99 纽约大学 W. M. Keck 基金会教授\r
1992-95 纽约大学 助教授\r
1990-92 哥伦比亚大学医学院 研究员（药物学，Cystic Fibrosis 基金会）\r
1988-90 哥伦比亚大学 博士后\r
1988 哥伦比亚大学 博士\r
1987 哥伦比亚大学 硕士（Master of Philosophy）\r
1984 哥伦比亚大学 硕士（Master of Art）\r
1982 山东大学 理学学士

研究领域

"""""抗可卡因、单克隆抗体、抗病毒研究和糖化学等研究领域"

近期论文

Xuming Li, Xiang Zhang, Daisy Zhang-Negrerie, Yunfei Du,* and Kang Zhao.* Construction of 1,4-Benzodiazepine Skeleton from 2-(Arylamino)benzamides through PhI(OAc)2-Mediated Oxidative C?N Bond Formation. J. Org. Chem. 2014, in press. \r
\r
Jinglei Lv, Daisy Zhang-Negrerie, Jun Deng, Yunfei Du* and Kang Zhao.*Synthesis Metal-free Synthesis of 2-Oxindoles via PhI(OAc)2-Mediated Oxidative C-C Bond Formation Cyclization. J. Org. Chem. 2014, DOI: 10.1021/jo4025539.\r
\r
Le Liu, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* PhICl2 and Wet DMF: An Efficient System for Regioselective Chloroformyloxylation/α-Chlorination of Alkenes/α,β-Unsaturated Compounds. Org. Lett. 2014, DOI: 10.1021/ol403321n. \r
\r
Zheng Zisheng, Zhang-Negrerie, Du Yunfei,* Zhao Kang.* The applications of hypervalent iodine(III) reagents in the constructions of heterocyclic compounds through oxidative coupling reactions. Sci. China, Ser. B. 2014, 57, 1– 25. (Invited Review Paper)\r
\r
Xiang Zhang, Daisy Zhang-Negrerie, Jun Deng, Yunfei Du* and Kang Zhao.* Synthesis of Diversely Substituted Indoloquinolinones via Pd(II)/Cu(II)-Mediated Oxidative C-C Bond Formation and I(III)-Mediated C-N Bond Formation. J. Org. Chem. 2013, 78, 12750–12759. \r
\r
Xiaoqian Sun, Youran Lyu, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* Formation of Functionalized 2H-Azirines through PhIO-Mediated Trifluoroethoxylation and Azirination of Enamines. Org. Lett. 2013, 15, 6222–6225. \r
\r
Yu, Qingzhen; Zhang, Nana; Huang, Jianhui; * Lu, Shaonan; Zhu, Yi; Yu, Xiaoxiao; Zhao, Kang. * Efficient Synthesis of Hydroxyl Isoindolones by a Pd-Mediated C-H Activation/Annulation Reaction. Chem. Eur. J. 2013, 19, 11184 – 11188. \r
\r
Lu, Shaonan; Lin, Yingfu; Zhong, Hongban; Zhao, Kang; * Huang, Jianhui. * A practical one-pot procedure for the synthesis of N-H isoquinolones. Tetrahedron Lett. 2013, 54, 2001-2005.\r
\r
Yang, Dan; Ding, Shixuan; Huang, Jianhui; * Zhao, Kang. * Pd-catalysed direct dehydrogenative carboxylation of alkenes: facile synthesis of vinyl esters. Chem. Commun. 2013, 49, 1211-1213. \r
\r
Ningning Zhang, Rui Yang, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* Direct Conversion of N-Alkoxyamides to Carboxylic Esters through Tandem NBS-Mediated Oxidative Homocoupling and Thermal Denitrogenation. J. Org. Chem. 2013, 78, 8705–8711.\r
\r
Yunhui Zheng, Chao Yang, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* One-Pot Synthesis of Isoxazoles from Enaminones: An Application of Fe(II) as the Catalyst for Ring Expansion of 2H-Azirine Intermediates. Tetrahdron Lett. 2013, 54, 6157 – 6160.\r
\r
Ran Cheng, Tianjian Guo, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* One-Pot Synthesis of Quinazolinones from Anthranilamides and Aldehydes via TsOH-Mediated Cyclocondensation and PIDA-Mediated Oxidative Dehydrogenation. Synthesis 2013, 45, 2998 – 3006.\r
\r
Qingzhen Yu, Nana Zhang, Jianhui Huang,* Shaonan Lu, Yi Zhu, Xiaoxiao Yu and Kang Zhao.* Efficient Synthesis of Hydroxyl Isoindolones by a Pd-Mediated C-H Activation/Annulation Reaction. Chem. Eur. J. 2013, in press. \r
\r
Shaonan Lu, Yingfu Lin, Hongban Zhong, Kang Zhao* and Jianhui Huang.* A Practical One-Pot Procedure for the Synthesis of N-H Isoquinolones. Tetrahedron Lett. 2013, 54, 2001-2005.\r
\r
Dan Yang, Shixuan Ding, Jianhui Huang* and Kang Zhao.* Pd-catalysed Direct Dehydrogenative Carboxylation of Alkenes: Facile Synthesis of Vinyl Esters. Chem. Commun. 2013, 49, 1211-1213. \r
\r
Le Liu, Hang Lu, Hong Wang, Chao Yang, Xiang Zhang, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* PhI(OCOCF3)2-Mediated C-C Bond Formation Concomitant with a 1,2-Aryl Shift in a Metal-Free Synthesis of 3-Arylquinolin-2-ones. Org. Lett. 2013, 15, 2906–2909. \r
\r
Yucheng Yuan, Rui Yang, Daisy Zhang-Negrerie, Junwei Wang, Yunfei Du* and Kang Zhao.* One-pot Synthesis of 3-Hydroxyquinolin-2(1H)-ones from N-Phenylacetoacetamide via PhI(OCOCF3)2-Mediated alpha-Hydroxylation and H2SO4-Promoted Intramolecular Cyclization. J. Org. Chem. 2013, 78, 5385–5392.\r
\r
Jinglei Lv, Ji Li, Daisy Zhang-Negrerie, Siyun Shang, Qingzhi Gao, Yunfei Du* and Kang Zhao.* Constructions of Tetrahydro-γ-carboline Skeletons via Intramolecular Oxidative Carbon-Carbon Bond Formation of Enamines. Org. Biomol. Chem. 2013, 11, 1929–1932.\r
\r
Jinming Li, Huiyu Chen, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* Synthesis of coumarins via PIDA/I2-mediated oxidative cyclization of substituted phenylacrylic acids. RSC Adv. 2013, 3, 4311 – 4320.\r
\r
Yunhui Zheng, Xuming Li, Chengfeng Ren, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* Synthesis of Oxazoles from Enamides via Phenyliodine Diacetate-Mediated Intramolecular Oxidative Cyclization. J. Org. Chem. 2012, 77, 10353–10361. SCI: 037AI. Highlighted by SYNFACTS, 2013, 9, 0146 (Abstracted by Organic Syntheses).\r
\r
Xin Liu, Ran Cheng, Feifei Zhao, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* Direct β-Acyloxylation of Enamines via PhIO-Mediated Intermolecular Oxidative C-O Bond Formation and Its Application to the Synthesis of Oxazoles. Org. Lett. 2012, 14, 5480 – 5483. SCI: 039KV (Highlighted by Organic Chemistry Portal).\r
\r
Xi-Liu Yun, Wen-Ying Bi, Jian-Hui Huang, Yu Liu, Daisy Zhang-Negrerie, Yun-Fei Du* and Kang Zhao.* Synthesis of N-Substituted Carbazolones from α-Iodo Enaminones via Pd(0)-Catalyzed Intramolecular Coupling under Microwave Irradiation. Tetrahedron. Lett. 2012, 53, 5076-5080. SCI: 001IP. \r
\r
Qingzhen Yu, Nan Zhang, Yang Tang, Hang Lu, Jianhui Huang, Songqing Wang, Yunfei Du,* Kang Zhao.* Cu(II)-Mediated Cascade Oxidative C-C Coupling and Aromatization: Synthesis of 3-Hydroxy-phenanthridinone Derivatives. Synthesis 2012, 44, 2374-2384. SCI: 988BH.\r
\r
Junwei Wang, Yucheng Yuan, Rui Xiong, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* PIFA-Mediated Oxidative C-C Bond Formation: Synthesis of 3-Hydroxy-2-oxindoles and Spirooxindoles from Anilides. Org. Lett. 2012, 14, 2210-2213. SCI: 935BN (Abstracted by Methods in Organic Synthesis Database)\r
\r
Le Liu, Yanfeng Fan, Qiaoqiao He, Yun Zhang, Daisy Zhang-Negrerie, Jianhui Huang,* Yunfei Du* and Kang Zhao. Synthesis of Highly Functionalized Fluorescent Indenes from Electron-rich ?-Aryl Ketonitriles. J. Org. Chem. 2012, 77, 3997-4004. SCI: 928KQ (Highlighted by SYNFACTS, 2012, 8, 0728; Abstracted by ChemInform, 2012, DOI: 10.1002/chin.201232094, Abstracted by Methods in Organic Synthesis Database).