个人简历

天津大学教授，博士生导师，天津大学医学工程与转化医学研究院副院长，国家重点研发计划首席科学家，国家青年拔尖人才项目获得者（四青），科睿唯安“全球高被引科学家”（Highly Cited Researchers）（2021），爱思唯尔（Elsevier）中国高引学者（2020、2021、2022），天津市‘杰青’获得者。毕业于天津大学理学院获得博士学位，2013-2015年赴斯坦福大学戴宏杰院士课题组进行博士后研究。长期从事纳米生物医学和光学成像，独立提出‘团簇酶’的概念，实验对神经创伤的早期高效干预（Nat. Commun.2021）；独立构建超越天然酶反应亲和力的单原子纳米酶缝线和器械，实现对神经创伤对中期调控（Nat. Commun.2022），独立发现超快人工酶，实现对神经创伤的高效抑制和神经认知改善（Sci. Adv. 2019）；设计生物活性的红外二区团簇探针，实现高效病理监测（Adv. Mater. 2019）。在过去几年的工作中，以第一或通讯作者身份发表SCI收录论文100多篇，包括Nature Communications 2篇（IF=17.6），Science Advances 1篇（IF=14.9），Advanced Materials 4篇（IF=30.8），Nano Letters 3篇（IF=11.1），ACS Nano 4篇（IF=18.0），Coordination Chemistry Reviews 3篇, Trends in Pharmacological Sciences1篇（IF=17.6）, Advanced Functional Materials 1篇（IF=19.9）。总引用次数超过10000多次，1篇热点论文，12篇论文入选ESI高被引。主持国家自然科学基金重大研究计划、联合基金、面上等5项国家基金。\r
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教育背景\r
天津大学凝聚态物理 硕士（2007），导师：刘昌龙\r
天津大学材料物理与化学 博士（2012），导师：刘昌龙\r
美国斯坦福大学 博士后（2013-2015），导师：戴宏杰（Hongjie Dai）\r
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工作经历\r
天津大学 教授（2018-）\r
天津大学 研究员（2016-）\r
中国医学科学院放射医学研究所（2007-2013）

研究领域

""（1）超小团簇分子的物理化学设计及其在重大疾病中应用。\r
（2）深组织近红外二区（1,100-1700 nm）荧光成像技术在重大疾病方面的应用。\r
（3）神经电极的原子分子设计、界面电子输运和重大疾病诊断和干预""""

近期论文

Shaofang Zhang, Yonghui Li, Si Sun, Ling Liu, Xiaoyu Mu, Shuhu Liu, Menglu Jiao, Xinzhu Chen, Ke Chen, Huizhen Ma, Tuo Li, Xiaoyu Liu, Hao Wang, Jianning Zhang, Jiang Yang & Xiao-Dong Zhang*, Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma, Nature Communications, 2022 (设计了超越天然酶亲和力的单原子纳米酶，唯一通讯作者).\r
https://www.nature.com/articles/s41467-022-32411-z\r
http://news.tju.edu.cn/info/1012/61947.htm\r
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Xiaoyu Mu, Junying Wang, Hua He, Qifeng Li, Bing Yang, Junhui Wang, Haile Liu, Yalong Gao, Lufei Ouyang, Si Sun, Qinjuan Ren, Xinjian Shi, Wenting Hao, Qiaoman Fei, Jiang Yang, Lulin Li, Ryan Vest, Tony Wyss-Coray, Jian Luo, and Xiao-Dong Zhang*, An Oligomeric Semiconducting Nanozyme with Ultrafast Electron Transfers Alleviates Acute Brain Injury, Science Advances, 2021 (设计了具有超快电子转移的短聚物纳米酶，可以大缓解急性脑损伤症状，唯一通讯作者)。\r
https://www.science.org/doi/full/10.1126/sciadv.abk1210\r
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Haile Liu, Yonghui Li, Si Sun, Qi Xin, Shuhu Liu, Xiaoyu Mu, Xun Yuan, Ke Chen, Hao Wang, Kalman Varga, Wenbo Mi, Jiang Yang & Xiao-Dong Zhang*, Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions, Nature Communications, 2021.(提出团簇酶Clusterzyme的概念,揭示对神经炎症的调控, 入选Nature Communications的Editor Choice，入选ESI高被引，唯一通讯作者)，相关学术媒体的报道：\r
http://news.tju.edu.cn/info/1003/54635.htm \r
http://www.xinhuanet.com/tech/2021-01/11/c_1126970056.htm \r
https://www.hubpd.com/c/2021-01-11/985276.shtml\r
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Shuangjie Liu, Ling Liu, Yue Zhao, Yang Wang, Yingpeng Wu, Xiao-Dong Zhang*, and Dong Ming*, A High-Performance Electrode Based on van der Waals Heterostructure for Neural Recording, Nano Letters, 2022, 22, 11, 4400–4409 (范德瓦尔斯异质结高性能神经电极).\r
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Si Sun, Haile Liu, Qi Xin, Ke Chen, Huizhen Ma, Shuhu Liu, Xiaoyu Mu, Wenting Hao, Shuangjie Liu, Yalong Gao, Yang Wang, Jiahui Pei, Ruoli Zhao, Shaofang Zhang, Xiaoning Zhang, Hao Wang, Yonghui Li*, and Xiao-Dong Zhang*, Atomic Engineering of Clusterzyme for Relieving Acute Neuroinflammation through Lattice Expansion, Nano Letters, 2021.\r
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Yuanyuan Yang, Yingjie Yu, Hao Chen, Xiangxi Meng, Wen Ma, Meng Yu, Ziyuan Li, Changhui Li, Haile Liu, Xiaodong Zhang*, Haihua Xiao*, and Zhiqiang Yu*, illuminating platinum transportation while maximizing therapeutic efficacy by gold nanoclusters via simultaneous near-infrared-i/ii imaging and glutathione scavenging, ACS Nano, 2020.\r
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Haile Liu, Guosong Hong, Zhentao Luo, Junchi Chen, Junlei Chang, Ming Gong, Hua He, Jiang Yang, Xun Yuan, Lulin Li, Xiaoyu Mu, Junying Wang, Wenbo Mi, Jian Luo, Jianping Xie*, and Xiao-Dong Zhang *, Atomic Precision Gold Clusters for NIR-II Imaging, Advanced Materials, 2019（原子精度红外二区造影剂的构建及其对神经系统疾病的实时成像，ESI高被引）.\r
学术新闻：http://physics.tju.edu.cn/news/details/10264/\r
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Ruijuan Yan, Si Sun, Jiang Yang, Wei Long, Junying Wang, Xiaoyu Mu, Qifeng Li, Wenting Hao, Shaofang Zhang, Haile Liu, Yalong Gao, Lufei Ouyang, Junchi Chen, Shuangjie Liu, Xiao-Dong Zhang,*, Dong Ming,* A Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma, ACS Nano, 2019,（单原子纳米酶神经绷带的构建）.\r
学术新闻：http://news.tju.edu.cn/info/1012/47197.htm\r
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Xiaoyu Mu, Hua He, Junying Wang, Wei Long, Qifeng Li, Haile Liu, Yalong Gao, Lufei Ouyang, Qinjuan Ren, Si Sun, Jingya Wang, Jiang Yang, Qiang Liu, Yuanming Sun, Changlong Liu, Xiao-Dong Zhang*, Wenping Hu, Carbogenic Nanozyme with Ultrahigh RNS Selectivity for Traumatic Brain Injury, Nano Letters, 2019.\r
学术新闻：http://physics.tju.edu.cn/news/details/10260/ \r
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Xiaoyu Mu, Junying Wang, Yonghui Li, Fujuan Xu, Wei Long, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Haitao Dai, Qiang Liu, Yuanming Sun, Changlong Liu, and Xiao-Dong Zhang*, Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury, ACS Nano, 2019.\r
学术新闻：http://physics.tju.edu.cn/news/details/10260/\r
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Qinglai Yang, Zhuoran Ma, Huasen Wang, Bin Zhou, Shoujun Zhu, Yeteng Zhong, Junying Wang, Hao Wan, Alexander Antaris, Rui Ma, Xiao Zhang, Jingyi Yang, Xiaodong Zhang*, Haitao Sun*, Weiqiang Liu, Yongye Liang*, Hongjie Dai*, Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window, Advanced Materials, 28, 2017 (ESI高被引论文，引用次数=188).\r
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Xiao-Dong Zhang, Huasen Wang, Alexander L Antaris, Lulin Li, Shuo Diao, Rui Ma, Andy Nguyen, Guosong Hong, Zhuoran Ma, Joy Wang, Shoujun Zhu, Joseph M Castellano, Tony Wyss-Coray, Yongye Liang*, Jian Luo*, Hongjie Dai*, Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore, Advanced Materials, 28, 2016 (引用次数=247).\r
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Xiao-Dong Zhang*, Jinxuan Zhang, Junying Wang, Jiang Yang, Jie Chen, Xiu Shen, Jiao Deng, Dehui Deng, Wei Long, Yuan-Ming Sun, Changlong Liu, Meixian Li*, Highly Catalytic Nanodots with Renal Clearance for Radiation Protection, ACS Nano, 10 (2016) 4511-4519.\r
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Xiao-Dong Zhang*, Zhentao Luo, Jie Chen, Xiu Shen, Shasha Song, Yuanming Sun, Saijun Fan, Feiyue Fan, David Tai Leong, Jianping Xie*, Ultrasmall Au10-12(SG)10-12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy. Advanced Materials, 26 (2014) 4565-4568 (ESI高被引论文, 引用次数=365).