个人简历

Education Experience 2003-2009 Ph. D. Biochemistry and Biomedical Sciences McMaster University 1999-2003 Bachelor of Science Life Sciences Fudan University Professional Experience 2016- Associate Professor Tianjin Univeristy 2010-2016 Research Associate Univeristy of British Columbia 2009-2010 Postdoctoral Fellow Cold Spring Harbor Laboratory

研究领域

The research of Yuchi’s group centers on the structure and function of ion channels. Ion channels are the second largest target class for approved drugs. Drugs targeting ion channels are used to treat arrhythmia, neuropathic pain, epilepsy, anxiety and more. The ultimate goal of our group is to understand the physiological and pathological roles of ion channels at the molecular level. The specific questions we are tackling include: 1) the interaction network and regulation of ion channels involved in heart and muscle diseases; 2) how disease-causing mutations perturb the structure and function of critical ion channels; 3) how to target insect ion channels to develop novel biopesticides. To answer these questions, our lab combines a variety of complementary techniques, including X-ray crystallography, electrophysiology, calorimetry, in-silico drug screening, as well as many other biochemical, biophysical and computational methods.

近期论文

2018 A two-step purification strategy using calmodulin as an affinity tag Lin, Lianyun; Liu, Chen; Nayak, Bidhan Chandra; et al. Journal of chromatography. A 2018 Pathogenic mechanism of a catecholaminergic polymorphic ventricular tachycardia causing-mutation in cardiac calcium release channel RyR2 Xiong, Jing; Liu, Xijun; Gong, Yunyun; et al. Journal of Molecular and Cellular Cardiology 117 2017 Crystal structure of ryanodine receptor N-terminal domain from Plutella xylostella reveals two potential species-specific insecticide-targeting sites Lin, Lianyun; Liu, Chen; Qin, Juan; et al. Insect biochemistry and molecular biology 92 2017 The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry Roston, Thomas M.; Yuchi, Zhiguang; Kannankeril, Prince J.; et al. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2016 Ryanodine receptors under the magnifying lens: Insights and limitations of cryo-electron microscopy and X-ray crystallography studies Yuchi, Zhiguang; Van Petegem, Filip Cell Calcium 2015 Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant Yuchi, Zhiguang; Yuen, Siobhan M. Wong King; Lau, Kelvin; et al. Nature Communications 6 2015 De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome Wang, Lumin; Meng, Xiangyun; Yuchi, Zhiguang; et al. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 36 2013 Structural Insights Into Disease Mutations of the Ryanodine Receptor Zhiguang Yuchi, Lynn Kimlicka; Van Petegem, Filip Genetic Disorders 2013 The cardiac ryanodine receptor N-terminal region contains an anion binding site that is targeted by disease mutations Kimlicka, Lynn; Tung, Ching-Chieh; Carlsson, Anna-Carin Cecilia; et al. Structure 21 2012 Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain Yuchi, Zhiguang; Lau, Kelvin; Van Petegem, Filip Structure 20 2011 Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors Yuchi, Zhiguang; Van Petegem, Filip; Crystallographic, R. Channels 2009 An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel Yuchi, Zhiguang; Pau, Victor P. T.; Lu, Bridget X.; et al. FEBS Journal 276 2008 GCN4 enhances the stability of the pore domain of potassium channel KcsA Yuchi, Zhiguang; Pau, Victor P. T.; Yang, Daniel S. C. FEBS Journal 275 2007 Characterization of the C-terminal Domain of a Potassium Channel from Streptomyces lividans (KcsA) Pau, Victor P. T.; Zhu, Yongfang; Yuchi, Zhiguang; et al. Journal of Biological Chemistry 282 2004 Impaired reproduction in transgenic mice overexpressing Gamma-aminobutyric acid transporter I (GAT1) Hu, Jia Hua; Zhang, Jin Fu; Ma, Ying Hua; et al. Cell research 14