个人简历
2011 Ph. D. University of Kansas Medical Center, KA, USA 2011 Postdoctoral Elan Pharma, Inc., CA; 2013, Apricity, Inc. &
研究领域
The research in Zhang’s group focuses on the function of transporters and nuclear receptors in pharmacology and toxicology. The major projects include: 1) preclinical development of novel transporter/receptor-targeted drugs for metabolic diseases and cancer; 2) mechanistic study of drug(herb)-induced liver and intestine injuries; 3) regulatory mechanisms of genes involved in cell death and diseases.
近期论文
2015 Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice. Selwyn, Felcy Pavithra; Csanaky, Ivan L; Zhang, Youcai; et al. Drug metabolism and disposition: the biological fate of chemicals 43 2015 Prediction and validation of enzyme and transporter off-targets for metformin Yee, Sook Wah; Lin, Lawrence; Merski, Matthew; et al. Journal of Pharmacokinetics and Pharmacodynamics 42 2014 Decreased Bile-Acid Synthesis in Livers of Hepatocyte-Conditional NADPH-Cytochrome P450 Reductase-Null Mice Results in Increased Bile Acids in Serum Cheng, Xingguo; Zhang, Youcai; Klaassen, Curtis D. Journal of Pharmacology and Experimental Therapeutics 351 2014 Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice Zhang, Youcai; Limaye, Pallavi B.; Renaud, Helen J.; et al. Toxicology and Applied Pharmacology 277 2014 OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin Chen, Ligong; Shu, Yan; Liang, Xiaomin; et al. Proceedings of the National Academy of Sciences of the United States of America 111 2013 Hormonal regulation of Cyp4a isoforms in mouse liver and kidney Zhang, Youcai; Klaassen, Curtis D. Xenobiotica 43 2013 Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice Liu, Jie; Lu, Yuan-Fu; Zhang, Youcai; et al. Toxicology and Applied Pharmacology 272 2013 Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism Zhang, Youcai; Csanaky, Ivan L.; Selwyn, Felcy Pavithra; et al. Biochemical Pharmacology 86 2013 Reduced Renal Clearance of Cefotaxime in Asians with a Low-Frequency Polymorphism of OAT3 (SLC22A8) Yee, Sook Wah; Anh Nguyet Nguyen; Brown, Chaline; et al. Journal of Pharmaceutical Sciences 102 2012 Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice Zhang, Youcai; Limaye, Pallavi B.; Lehman-McKeeman, Lois D.; et al. Plos One 7 2012 Effect of bile duct ligation on bile acid composition in mouse serum and liver Zhang, Youcai; Hong, Ji-Young; Rockwell, Cheryl E.; et al. Liver International 32 2012 Glucose and Insulin Induction of Bile Acid Synthesis MECHANISMS AND IMPLICATION IN DIABETES AND OBESITY Li, Tiangang; Francl, Jessica M.; Boehme, Shannon; et al. Journal of Biological Chemistry 287 2012 Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice Kong, Bo; Wang, Li; Chiang, John Y. L.; et al. Hepatology 56 2012 Nrf2 protects against diquat-induced liver and lung injury Wu, Kai Connie; Zhang, Youcai; Klaassen, Curtis D. Free Radical Research 46 2012 Organic Anion Transporting Polypeptide 1a1 Null Mice Are Sensitive to Cholestatic Liver Injury Zhang, Youcai; Csanaky, Ivan L.; Cheng, Xingguo; et al. Toxicological Sciences 127 2012 Transcription Factor-Mediated Regulation of Carboxylesterase Enzymes in Livers of Mice Zhang, Youcai; Cheng, Xingguo; Aleksunes, Lauren; et al. Drug Metabolism and Disposition 40 2011 Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles Gong, Lei; Aranibar, Nelly; Han, Yong-Hae; et al. Toxicological Sciences 122 2011 Dose-Response of Five Bile Acids on Serum and Liver Bile Acid Concentrations and Hepatotoxicty in Mice Song, Peizhen; Zhang, Youcai; Klaassen, Curtis D. Toxicological Sciences 123 2011 LOSS OF OATP1A1 FUNCTION INCREASES DEOXYCHOLIC ACID HEPATOTOXICITY IN MICE BY INCREASING INTESTINAL PERMEABILITY Zhang, Youcai; Csanaky, Ivan L.; Lehman-McKeeman, Lois D.; et al. Hepatology 54 2011 Loss of Organic Anion Transporting Polypeptide 1a1 Increases Deoxycholic Acid Absorption in Mice by Increasing Intestinal Permeability Zhang, Youcai; Csanaky, Ivan L.; Lehman-McKeeman, Lois D.; et al. Toxicological Sciences 124
