个人简历

Education Experience 1990-1994 Bachelor of Science Department of Chemistry, Organic Chemistry Lanzhou University 1996-1999 M.S. School of Life Sciences, Biochemistry and Molecula Lanzhou University 2000-2003 Ph. D. Institute for Viral Disease Control, Pathogenic Bi Chinese CDC 2003-2004 Postdoctoral Weill Cornell Medical College, Biochemistry Cornell University 2004-2009 Postdoctoral School of Public Health, Molecular Microbiology an Johns Hopkins University Professional Experience 1994-1996 Research fellow Ministry of Health Lanzhou Institute of Biologic Products, First Research Department (Dept. of Bacte 1999-2000 Research fellow Surveying-Designing Institute of Land Reclamation in Gansu Province 2009-2013 Professor Chinese CDC, Institute for Viral Disease Control 2013- Professor Tianjin University, School of Life Sciences

研究领域

Innate immunity is the first line of host defense against invading pathogenic microorganisms, where type I interferon (IFN) production is initiated at the early stages and subsequently induces the expression of IFN-stimulated genes (ISGs) in an autocrine and paracrine manner, leading to the destruction of invading pathogens. In order to replicate and survive, viruses have evolved diverse strategies to evade IFN responses. One area of research in my laboratory is to understand the molecular mechanisms of evasion of innate immunity by pathogenic microorganisms. Another goal of our research is to study the molecular mechanisms of severe fever with thrombocytopenia syndrome virus (SFTSV) and enteroviruss D68 pathogenesis. Key scientific issues 1) Innate detection of viral pathogenic microorganisms; 2) The mechanism of ubiquitin in the antiviral signaling pathway; 3) The molecular mechanism of the generation and regulation of type I interferon and other important cytokines by natural immune activation; 4) The mechanism of cytokine secretion after natural immune activation;

近期论文

2014 [Severe fever with thrombocytopenia syndrome virus nucleoprotein specifically binds to 60kD SSA/Ro protein in host cells]. Zheng, Bin; Wang, Tao; Zhang, Shuo; et al. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] 30 2013 Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential Jiao, Lianying; Ouyang, Songying; Liang, Mifang; et al. Journal of Virology 87 2012 Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model Jin, Cong; Liang, Mifang; Ning, Junyu; et al. Proceedings of the National Academy of Sciences of the United States of America 109 2012 [Establishment of minireplicon system for severe fever with thrombocytopenia syndrome bunyavirus]. Yu, Xia-Li; Jiang, Xiao-Lin; Wang, Tao; et al. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] 28 2011 Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China Yu, Xue-Jie; Liang, Mi-Fang; Zhang, Shou-Yin; et al. New England Journal of Medicine 364 2011 [Expression of structural and non-structural proteins of severe fever with thrombocytopenia syndrome bunyavirus]. Lu, Jing; Li, Chuan; Zhang, Fu-Shun; et al. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] 27 2010 A Single Amino Acid Difference in Human APOBEC3H Variants Determines HIV-1 Vif Sensitivity Zhen, Anjie; Wang, Tao; Zhao, Ke; et al. Journal of Virology 84 2010 Hantavirus-like particles generated in CHO cells induce specific immune responses in C57BL/6 mice Li, Chuan; Liu, Feng; Liang, Mifang; et al. Vaccine 28 2010 Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42 Wang, Qin; Li, Chuan; Zhang, Quanfu; et al. Virology Journal 7 2010 Tracking hantavirus nucleocapsid protein using intracellular antibodies Li, Jiandong; Zhang, Quanfu; Wang, Tao; et al. Virology Journal 7 2009 A Patch of Positively Charged Amino Acids Surrounding the Human Immunodeficiency Virus Type 1 Vif SLVx4Yx9Y Motif Influences Its Interaction with APOBEC3G Chen, Gongying; He, Zhiwen; Wang, Tao; et al. Journal of Virology 83 2009 Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase Ehrlich, Elana S.; Wang, Tao; Luo, Kun; et al. Proceedings of the National Academy of Sciences of the United States of America 106 2008 Conserved and non-conserved features of HIV-1 and SIVagm Vif mediated suppression of APOBEC3 cytidine deaminases Zhang, Wenyan; Huang, Michael; Wang, Tao; et al. Cellular Microbiology 10 2008 Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression Zhang, Wei; Zhang, Xuzhao; Tian, C.; et al. Cellular Microbiology 10 2008 Distinct viral determinants for the packaging of human cytidine deaminases APOBEC3G and APOBEC3C Wang, Tao; Zhang, Wenyan; Tian, Chunjuan; et al. Virology 377 2008 Interaction with 7SL RNA but not with HIV-1 genomic RNA or p bodies is required for APOBEC3F virion packaging Wang, Tao; Tian, Chunjuan; Zhang, Wenyan; et al. Journal of Molecular Biology 375 2007 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G Wang, Tao; Tian, Chunjuan; Zhang, Wenyan; et al. Journal of Virology 81 2007 Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation Luo, Kun; Wang, Tao; Liu, Bindong; et al. Journal of Virology 81 2007 Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association Niewiadomska, Anna Maria; Tian, Chunjuan; Tan, Lindi; et al. Journal of Virology 81 2007 Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles Tian, Chunjuan; Wang, Tao; Zhang, Wenyan; et al. Nucleic Acids Research 35