个人简历
Education Experience 2009 Ph. D. National University of Singapore, Singapore 2010-2013 Postdoctoral University of Cambridge, United Kingdom Professional Experience 2013-2016 Scientist I Singapore's Agency for Science, Technology, and Research, ICES
研究领域
The research in the group of Srinivasan encompasses two main areas, 1) Developing new reaction methodologies: The research topics under this area include bioorthogonal reactions, late-stage modification of advanced chemical entities, C-H activation, and high-throughput amenable synthesis – aiming at advancing the way organic molecules are made for drug discovery and chemical biology applications. 2) Inhibitor discovery based on fragment-based approaches: Design and synthesis of ‘unconventional’ fragments with rich structural diversity. These fragments will be used as a starting point towards novel inhibitors for unexplored biological targets such as the AurB-INCENP interaction.
近期论文
2016 Divergent Synthesis of Dihydroxanthene-Hemicyanine Fused Near-Infrared Fluorophores through the Late-Stage Amination of a Bifunctional Precursor Ong, Michelle Jui Hsien; Srinivasan, Rajavel; Romieu, Anthony; et al. Organic Letters 18 2015 An amidation/cyclization approach to the synthesis of N-hydroxyquinolinones and their biological evaluation as potential anti-plasmodial, anti-bacterial, and iron(II)-chelating agents Teng, Yanbo; Suwanarusk, Rossarin; Ngai, Mun Hong; et al. Bioorganic & Medicinal Chemistry Letters 25 2014 Regioselective Conversion of Arenes to N-aryl-1,2,3-triazoles Using C-H Borylation Srinivasan, Rajavel; Coyne, Anthony G.; Abell, Chris Chemistry-a European Journal 20 2009 High-Throughput Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (MptpB) Inhibitors Using Click Chemistry Tan, Lay Pheng; Wu, Hao; Yang, Peng-Yu; et al. Organic Letters 11 2009 High-throughput synthesis of azide libraries suitable for direct "click" chemistry and in situ screening Srinivasan, Rajavel; Tan, Lay Pheng; Wu, Hao; et al. Organic & Biomolecular Chemistry 7 2009 Site-specific covalent labeling of proteins inside live cells using small molecule probes Chattopadhaya, Souvik; Srinivasan, Rajavel; Yeo, Dawn S. Y.; et al. Bioorganic & Medicinal Chemistry 17 2008 Click synthesis of small-molecule inhibitors targeting caspases Ng, Su Ling; Yang, Peng-Yu; Chen, Kitty Y. -T.; et al. Organic & Biomolecular Chemistry 6 2008 In vivo imaging of a bacterial cell division protein using a protease-assisted small-molecule labeling approach Chattopadhaya, Souvik; Abu Bakar, Farhana B.; Srinivasan, Raiavel; et al. Chembiochem 9 2008 Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors Srinivasan, Rajavel; Tan, Lay Pheng; Wu, Hao; et al. Organic Letters 10 2008 Solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases Yang, Peng-Yu; Wu, Hao; Lee, Mei Yin; et al. Organic Letters 10
