Education Experience 2015-2017 Postdoctoral Molecular Pharmacology Tianjin University, China 2007-2012 Ph. D. Cell and Molecular Biology Colorado State University, USA 1994-1996 Master of Science Botany University of the Punjab, Pakistan 1992-1994 Bachelor of Science Pre-medical University of the Punjab, Pakistan Professional Experience 2015-2017 Charles Tenney Post-doctoral fellow Tianjin University, China 2012-2014 Assistant Professor National University of Sciences and Technology, Pakistan 2010-2012 Student scientist Colorado State University, USA 2003-2007 Assistant Professor Forman Christian University, Pakistan
研究领域
Primary Focus: Radiation Induced Bystander Mutagenesis (RIBE) Top: Construction of E-18 cell line (a modified WTK1 cell line) to measure bystander mutagenesis at a higher resolution. A unique 18 base sequence spliced into the TK1 gene of heterozygous host; which upon exogenous expression of the I-Sce1 restriction enzyme cuts at the 18 base sequence and renders a heterozygous cell line to homozygous recessive for the TK1 gene. Such recessive mutants can be screened using the mutation assay. Poisson distribution analysis allows the measurement of mutants in a 96 well assay to determine mutation frequency. Bottom: Comet assay employed for semi-quantification of I-Sce1 induced DNA damage in E-18 cells using fluorescence microscopy. Other research interests: Collaborating in the field of translational breast cancer research that is focused on identifying environmental risks, conceiving new therapeutic strategies, testing novel anti-cancer drugs and providing insight to develop new prototypes of biomedical equipment for in-vitro fertilization technology and tailored gene therapy. Also, interested in the screening of novel synthetic lead compounds (such as Akt 1, 2, 3) that have therapeutic potential against cancer target proteins.
近期论文
Noreen Akhtar, Ishrat Jabeen*, Nasir Jalal, Jon Antilla. (2018) Structure-Based Pharmacophore Models to Probe Anticancer Activity of Inhibitors of Protein Kinase B-beta (PKB β). Chemical Biology & Drug Design. DOI: 10.1111/cbdd.13418. Accepted Oct 21, 2018. Humaira Sawal, Kashif Asghar, Matthias Bureik, Nasir Jalal. * (2017) Bystander signaling via oxidative metabolism. Oncotargets and Therapy 10:3925-3940. https://doi.org/10.2147/OTT.S136076 Bilal Zulfiqar, Kaenat Nasir, Amnah Mahroo, Rai Khalid Farooq, Nasir Jalal, Gui-Bo Yang, Muhammad Usman Rashid, Kashif Asghar, Muhammad Ali A Shah,* (2017) Nanomedicine and cancer immunotherapy targeting indoleamine 2, 3-dioxygenase. OncoTargets and Therapy 2017:10 463–476. https://www.dovepress.com/nanomedicine--and--cancer--immunotherapy--focus--on--indoleamine--23--- peer-reviewed-article-OTT Nasir Jalal*, Austin R. Surendranath, Janak L. Pathak, Shi Yu, Chang Y. Chung. (2017) “Bisphenol A: the mighty and the mutagenic.” Toxicology Reports ISSN: 2214-7500, https://doi.org/10.1016/j.toxrep.2017.12.013 Science Direct Publishing group. Faria Khan; Naeem Akhtar; Nasir Jalal; Irshad Hussain; Rafal Szmigielski; Muhammad Qasim Hayat; Hafiz B. Ahmad; Waleed A. El-Said; Minghui Yang; Hussnain A. Janjua. (2017) \
