个人简历

Education Experience 1990-1993 Ph. D. Animal Science Tohoku University, Japan 1994-1995 Postdoctoral Cell Biology Stanford University Professional Experience 1995-2000 Associate Professor Tohoku University 2001-2005 Research Fellow Brigham and Women's Hospital/Harvard Medical School 2006-2008 Instructor Brigham and Women's Hospital/Harvard Medical School 2008-2016 Assistant Professor Brigham and Women's Hospital/Harvard Medical School 2016- Professor Tianjin University

研究领域

The Nakamura group focuses on the regulation of the cellular actin cytoskeleton and in particular on the molecular mechanisms of chemical and mechanical signal transduction (mechanotransduction), a conversion of mechanical forces into cellular biochemical signals. Mechanotransduction is essential for many physiological processes in diverse organisms during development and maintenance of all tissues. Defects in mechanotransduction, often caused by mutations or deregulation of proteins that disturb cellular or extracellular mechanics, are implicated in the development of various diseases, ranging from muscular dystrophies and hypertension-induced vascular and cardiac hypertrophy to cancer progression and metastasis. Despite its importance, little is known about the underlying mechanisms of mechanotransduction. The group uses a wide range of techniques including proteomics, microscopy, molecular biology, and cell biology, and appreciate collaboration with expertises in structural biology, mechanical engineering, single molecular analysis, computer simulation, and drug design.

近期论文

2016 An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu) Song, Mia; He, Qianjing; Berk, Benjamin-Andreas; et al. Biochemical and Biophysical Research Communications 469 2016 Arterial Myogenic Activation through Smooth Muscle Filamin A Retailleau, Kevin; Arhatte, Malika; Demolombe, Sophie; et al. Cell Reports 14 2016 DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk Justa-Schuch, Daniela; Silva-Garcia, Maria; Pilla, Esther; et al. Elife 5 2015 Filamin A interaction with the CXCR4 third intracellular loop regulates endocytosis and signaling of WT and WHIM-like receptors Gomez-Mouton, Concepcion; Fischer, Thierry; Peregil, Rosa M.; et al. Blood 125 2015 FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets Begonja, Antonija Jurak; Pluthero, Fred G.; Suphamungmee, Worawit; et al. Blood 126 2014 Binding of WIP to Actin Is Essential for T Cell Actin Cytoskeleton Integrity and Tissue Homing Massaad, Michel J.; Oyoshi, Michiko K.; Kane, Jennifer; et al. Molecular and Cellular Biology 34 2014 Documentation and localization of force-mediated filamin A domain perturbations in moving cells Nakamura, Fumihiko; Song, Mia; Hartwig, John H.; et al. Nature Communications 5 2014 Remodeling of the Intestinal Brush Border Underlies Adhesion and Virulence of an Enteric Pathogen Zhou, Xiaohui; Massol, Ramiro H.; Nakamura, Fumihiko; et al. Mbio 5 2013 Domain-Domain Interactions in Filamin A (16-23) Impose a Hierarchy of Unfolding Forces Xu, Tianyou; Lannon, Herbert; Wolf, Sebastein; et al. Biophysical Journal 104 2013 Filamin-A Regulates Neutrophil Uropod Retraction through RhoA during Chemotaxis Sun, Chunxiang; Forster, Carol; Nakamura, Fumihiko; et al. Plos One 8 2013 FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration Nakamura, Fumihiko Biochemical Journal 453 2013 Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function Chen, Hu; Chandrasekar, Saranya; Sheetz, Michael P.; et al. Scientific Reports 3 2012 Electron Microscopy and 3D Reconstruction Reveals Filamin Ig Domain Binding to F-Actin Suphamungmee, Worawit; Nakamura, Fumihiko; Hartwig, John H.; et al. Journal of Molecular Biology 424 2011 Differential Mechanical Stability of Filamin A Rod Segments Chen, Hu; Zhu, Xiaoying; Cong, Peiwen; et al. Biophysical Journal 101 2011 Improved High-Force Magnetic Tweezers for Stretching and Refolding of Proteins and Short DNA Chen, Hu; Fu, Hongxia; Zhu, Xiaoying; et al. Biophysical Journal 100 2011 Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A Ehrlicher, A. J.; Nakamura, F.; Hartwig, J. H.; et al. Nature 478 2011 Refilin holds the cap. Gay, Olivia; Nakamura, Fumihiko; Baudier, Jacques Communicative & integrative biology 4 2011 RefilinB (FAM101B) targets FilaminA to organize perinuclear actin networks and regulates nuclear shape Gay, Olivia; Gilquin, Benoit; Nakamura, Fumihiko; et al. Proceedings of the National Academy of Sciences of the United States of America 108 2011 The filamins Organizers of cell structure and function Nakamura, Fumihiko; Stossel, Thomas P.; Hartwig, John H. Cell Adhesion & Migration 5 2010 Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks Kasza, K. E.; Broedersz, C. P.; Koenderink, G. H.; et al. Biophysical Journal 99