个人简历

Education Experience 2005-2009 Bachelor of Engineering Bioinformatics Huazhong University of Science and Technology 2009-2014 Doctor of Philosophy Structural Biology Tsinghua University Professional Experience 2014-2019 Postdoc University of Pennsylvania 2019- Associate professor Tianjin Univesity

研究领域

The research interest of Mei lab focuses on the molecular mechanism underlying the regulation of vesicle trafficking. Vesicle trafficking is a fundamental cellular process by which membrane-encapsulated vesicles, including synaptic vesicles, transport materials between different cellular compartments and between a cell and its environment. Malfunction of vesicle trafficking will cause a broad spectrum of severe diseases, such as cancer, diabetes, immune deficiency and neuropathy. Vesicle trafficking occurs in four steps including vesicle biogenesis, transport, docking and fusion with the target membrane, each of which is mediated by a specific concert of protein families. Membrane fusion is mediated by the SNAREs and docking is manly mediated by the MTCs (Multi-subunit tethering complexes). MTCs are conserved in eukaryotes and different MTCs are involved in different stages of the secretory and endocytic pathway. MTCs not only mediate vesicle docking via tethering the trafficking vesicles to the target membrane, but also interact with the SNAREs to promote membrane fusion between them (Figure 1). However, the molecular mechanisms underlying these cellular processes are largely unknown.

近期论文

1. K. Mei and W. Guo. Exocytosis: A New Exocyst Movie. Current Biology, 2019, 29(1), R30-R32. 2. K. Mei, P. Yue，and W. Guo. Analysis of the Role of Sec3 in SNARE Assembly and Membrane Fusion. SNAREs, 175-189. (Springer New York, 2019) 3. K. Mei and W. Guo. The exocyst complex. Current Biology, 2018, 28(17), R922-R925. 4. K. Mei*, Y. Li*, S. Wang, G. Shao, J. Wang, Y. Ding, G. Luo, P. Yue, J.-J. Liu, X. Wang, M.-Q. Dong, H.-W. Wang, and W. Guo. Cryo-EM Structure of the Exocyst Complex, Nature structural & molecular biology, 2018, 25(2):139-146. 5. P. Yue*, Y. Zhang*, K. Mei, S. Wang, J. Lesigang, Y. Zhu, G. Dong, and W. Guo. Sec3 Promotes the Initial Binary T-Snare Complex Assembly and Membrane Fusion, Nature Communication, 2017, 8:14236. 6. S. Tang, Y. Si, Z. Wang, K. Mei, X. Chen, J. Cheng, J. Zheng, and L. Liu. An Efficient One‐Pot Four‐Segment Condensation Method for Protein Chemical Synthesis, Angewandte Chemie International Edition, 2015, 54(19): 5713-5717. 7. S. Yang*, Y. Wang*, K. Mei, S. Zhang, X. Sun, F. Ren, S. Liu, Z. Yang, X. Wang, Z. Qin, and Z. Chang. Tumor necrosis factor receptor 2 (TNFR2)· interleukin-17 receptor D (IL-17RD) heteromerization reveals a novel mechanism for NF-κB activation, Journal of Biological Chemistry, 2015, 290(2): 861-871. 8. K. Mei*, Z. Jin*, F. Ren, Y. Wang, Z. Chang, and X. Wang. Structural Basis for the Recognition of RNA Polymerase II C-Terminal Domain by CREPT and p15RS, Science China Life Sciences, 2014, 57(1): 97-106. 9. D. Wang, S. Zhang, L. Li, X. Liu, K. Mei, and X. Wang. Structural insights into the assembly and activation of IL-1 [beta] with its receptors, Nature immunology, 2010,11(10): 905-911.