个人简历

1997, 9 ― 2001, 6 河北大学 药物化学 理学学士\r
2001, 9 ― 2004, 6 河北大学 有机化学 理学硕士\r
2004, 9 ― 2007, 6 天津大学 应用化学 工学博士\r
2011, 5 ― 2012, 5 美国威斯康星大学 – 麦迪逊分校，博士后（Research Associate）\r
2007, 7 ― 2009, 6 天津大学药学院 讲师\r
2009, 7 ― 2013, 6 天津大学药学院 副教授\r
2012, 11― 2019, 4 天津大学药学院 副书记、副院长\r
2019, 4―现今 天津大学药学院 副院长\r
2013, 6 ― 2018, 6 天津大学药学院 特聘研究员\r
2018, 6 ― 现今 天津大学药学院 教授 博士生导师\r

研究领域

"""""1. 有机化学：高价碘化学、杂环化学\r
2. 药物合成：原料药及其中间体的新工艺研发"

近期论文

2020 \r
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106. Xuechan An, Beibei Zhang, Xiaoxian Li, Tianshu Du, Zhenkang Ai, Chenglin Zhang, Jun Xu, Fengxia Sun, Yilin Zhang, and Yunfei Du.* Construction of 4-(Methylthio)isochromenones Skeleton through Regioselective Intramolecular Cyclization of 2-Alkynylbenzoate Mediated by DMSO/[D6]DMSO and SOCl2. Eur. J. Org. Chem. 2020, 852-859. \r
105. Wei Zhang, Shanqing Tao, Huaibin Ge, Qiao Li, Zhenkang Ai, Xiaoxian Li, Beibei Zhang, Fengxia Sun, Xiaqing Xu, and Yunfei Du.* Construction of 2-Arylbenzo[4,5]thieno[2,3-d]thiazole Skeleton via CuCl/S-Mediated Three-Component Reaction. Org. Lett. 2020, 22, 2, 448-452. \r
104. Xiaoxian Li, Tongxing Liu, Beibei Zhang, Dongke Zhang, Haofeng Shi, Zhenyang Yu, Shanqing Tao, Yunfei Du.* Formation of Carbon-Carbon Bonds Mediated by Hypervalent Iodine Reagents Under Metal-free Conditions. Curr. Org. Chem. 2020, 24, 74-103. \r
103. Guangtao Zhang, Yuanxun Wang, Jun Xu, Jiyun Sun, Fengxia Sun, Yilin Zhang, Chenglin Zhang, and Yunfei Du.* A New Hypervalent Iodine(III/V) Oxidant and Its Application to the Synthesis of 2H-Azirines. Chem. Sci. 2020, 11, 947-953.\r
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2019 \r
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102. Qiao Li, Chen Zhuang, Donghua Wang, Wei Zhang, Rongxuan Jia, Fengxia Sun, Yilin Zhang, Yunfei Du.* Construction of Chromones Skeleton via PhIO-Mediated Dehydrogenation and Its Application to the Synthesis of Frutinone A. Beilstein J. Org. Chem. 2019, 15, 2958-2965. \r
101. Zhenghua Shang, Qingyu Xing, Linlin Xing,* Yilin Zhang, Laura Wait, and Yunfei Du.* in situ Formation of ArSCl/ArSeCl and Their Oxidative Coupling with Enaminone Derivatives Under Transition-metal Free Conditions. Adv. Synth. Catal. 2019, 361, 4926-4932.\r
100. Linlin Xing, Yong Zhang, Yilin Zhang, Zhenkang Ai, Xuemin Li, Yunfei Du,* Jun Deng,* and Kang Zhao. Regioselective Chlorolactonization of Styrene-type Carboxylic Esters and Amides via PhICl2-Mediated Oxidative C-O/C-Cl Bond Formations. J. Org. Chem. 2019, 84, 13832-13840.\r
99. Qingyu Xing, Huiyuan Liang, Mingmai Bao, Xuemin Li, Jingran Zhang, Tianhao Bi, Yilin Zhang, Jun Xu, Yunfei Du,* and Kang Zhao.* Metal-free Synthesis of Spiro-2,2’-benzo[b]furan-3,3’-ones via PhI(OAc)2-Mediated Cascade Spirocyclization. Adv. Synth. Catal. 2019, 361, 4669-4673.\r
98. Xiang Zhang, Xintong Wan, Ying Cong, Xiaohua Zhen, Qiao Li, Daisy Zhang-Negrerie, Yunfei Du,* and Kang Zhao.* Selective Lactonization of 2-Alkynylbenzoates for the Assembly of Isochromenones Solely Mediated by BF3•Et2O. J. Org. Chem. 2019, 84, 10402-10411. \r
97. Xinlin Xing, Yong Zhang, Bing Li, Yunfei Du.* in situ Formation of RSCl/ArSeCl and Their Application to the Synthesis of 4-Chalcogenylisocumarins/Pyrones from o-(1-Alkynyl)benzoates and (Z)-2-Alken-4-ynoates. Org. Lett. 2019, 21, 3620-3624. \r
96. Yuanxun Wang, Qiuyu Fu, Yu Zhou, Yunfei Du, Niu Huang.* The replacement of protein binding-site waters contributes to favorable halogen bond interactions. J. Chem. Info. Modeling 2019, 59, 3136-3143.\r
95. Linlin Xing, Yong Zhang, Bing Li, and Yunfei Du.* Synthesis of 4-Chloroisocoumarins via Intramolecular Halolactonization of o-Alkynylbenzoates: PhICl2-Mediated C–O/C–Cl Bond Formation. Org. Lett. 2019, 21,1989-1993. \r
94. Xiaohua Zhen, Xintong Wan, Wei Zhang, Qiao Li, Daisy Zhang-Negrerie, and Yunfei Du.* Synthesis of Spirooxindoles from N-Arylamide Derivatives via Oxidative C(sp2)–C(sp3) Bond Formation Mediated by PhI(OMe)2 Generated in Situ. Org. Lett. 2019, 21, 890–894. \r
93. Senlin Wang, Xue Zhao, Daisy Zhang-Negrerie, and Yunfei Du.*Reductive Cleavage of N-O Bond: Elemental Sulfur-Mediated Conversion of N-Alkoxyamides to Amides. Org. Chem. Front. 2019, 6, 347–351. \r
92. Linlin Xing, Yong Zhang and Yunfei Du.* Hypervalent Iodine-Mediated Synthesis of Spiroheterocycles via Oxidative Cyclization. Curr. Org. Chem. 2019, 23, 14–37.\r
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2018\r
91. Xiaoyuan Zhao, Qiao Li, Jun Xu, Donghua Wang, Daisy Zhang-Negrerie, Yunfei Du.* Cascade Synthesis of Benzothieno[3,2-b]indoles Under Oxidative Conditions Mediated by CuBr and tert-Butyl Hydroperoxide. Org. Lett. 2018, 20, 5933-5937.\r
90. Yin-Long Li, Xue-Lin Wang, Dan Xiao, Ming-Ying Liu, Yunfei Du and Jun Deng.* Highly Enantioselective Decarboxylative Aldol Reaction of Fluorinated α-Keto Acids with Unprotected Isatins: Synthesis of Difluoro/monofluoroalkyl 3-hydroxyoxindoles. Adv. Synth. Catal. 2018, 360, 4147-4152. \r
89. Yu Zhou, Yuanxun Wang, Pengfei Li, Xi-Ping Huang, Yunfei Du, Xiangbing Qi, and Niu Huang.* Exploring Halogen Bonds in 5-Hydroxytryptamine 2B Receptor-Ligand Interactions. ACS Med. Chem. Lett. 2018, 9, 1019 - 1024. \r
88. Longyang Dian, Qingyu Xing, Daisy Zhang-Negrerie, and Yunfei Du.* Sp3 C-H Functionalization of Alkyl Ethers for the Construction of Hemiaminal Ether Skeletons (HESs). Org. Biomol. Chem. 2018, 16, 4384–4398. \r
87. Jiyun Sun, Xiaohua Zhen, Huaibin Ge, Guangtao Zhang, Xuechan An, and Yunfei Du.* Synthesis of Trifluoromethyled 2H-Azirines through Togni Reagent-Mediated Trifluoromethylation Followed by PhIO-Mediated Azirination. Beilstein J. Org. Chem. 2018, 14, 1542–1458 (invited special journal).\r
86. Jiyun Sun, Guangchen Li, Ying Cong, Guangtao Zhang, Xuechan An, Daisy Zhang-Negrerie, and Yunfei Du.* Cascade Formation of C3-Unsymmetric Spirooxindoles via PhI(OAc)2-Mediated Oxidative C–C/C–N Bond Formation. Adv. Synth. Catal. 2018, 360, 2476-2486.\r
85. Yong Zhang, Xiaoyuan Zhao, Chen Zhuang, Senlin Wang, Daisy Zhang-Negrerie, and Yunfei Du.* PhIO/Et3N·3HF-Mediated Formation of Fluorinated 2H-Azirines via Cascade Fluorination and Azirination of Enamines. Adv. Synth. Catal. 2018, 360, 2107–2112.\r
84. Jiyun Sun, Huaibin Ge, Xiaohua Zhen, Xuechan An, Guangtao Zhang, Daisy Zhang-Negrerie, and Yunfei Du,* and Kang Zhao.* Tetrahedron 2018, 74, 2107-2114.\r
83. Jiyun Sun, Daisy Zhang-Negrerie, and Yunfei Du,* Kang Zhao.* Synthesis of N-Containing Heterocycles via Hypervalent Iodine(III)-Mediated Intramolecular Oxidative Cyclization. Advances in Organic Synthesis. Ebook Series of Bentham Science Publishers. eISBN: 978-1-68108-564-7, 2018, 8, 175-223.\r
82. Desong Sun, Xiaoyuan Zhao, Bobo Zhang, Ying Cong, Xintong Wan, Mingmai Bao, Xue Zhao, Bing Li, Daisy Zhang-Negrerie, and Yunfei Du.* Synthesis of Spirofurooxindoles via PhI(OCOCF3)2-Mediated Cascade Oxidative C–O and C–C Bond Formation. Adv. Synth. Catal. 2018, 360,1634-1638. \r
81. Ran Cheng, Wakana Mori, Longle Ma, Mireille Alhouayek, Akiko Hatori, Yiding Zhang, Daisuke Ogasawara, Gengyang Yuan, Zhen Chen, Xiaofei Zhang, Hang Shi, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuji Nagai, Takafumi Minamimoto, Mona Svensson, Lu Wang, Yunfei Du, Mary Jo Ondrechen, Neil Vasdev, Benjamin Cravatt, Christopher Fowler, Ming-Rong Zhang.* and Steven H. Lian.* In Vitro and in Vivo Evaluation of11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies. J. Med. Chem. 2018, 61, 2278-2291.\r
80. Zhongxiang Yun, Ran Cheng, Jiyun Sun, Daisy Zhang-Negrerie, and Yunfei Du.* PhICl2/ZnCl2-Mediated Synthesis of N-Alkoxyindole-3-carbonitriles from 3-Alkoxyimino-2-arylalkylnitriles via Intramolecular Heterocyclization. Adv. Synth. Catal. 2018, 360, 250-254.\r
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2017及以前\r
Bei Hu, Yang Cao, Bobo Zhang, Daisy Zhang-Negrerie, and Yunfei Du.* Formation of Phenyliodonio‐Substituted Spirofurooxindole Trifluoroacetates from N‐Substituted 3‐Oxopentanediamides via Phenyliodine Bis(trifluoroacetate)‐Mediated Oxidative Cascade Reactions. Adv. Synth. Catal. 2017, 359, 2542-2548.\r
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Bobo Zhang, Xiang Zhang, Bei Hu, Desong Sun, Senlin Wang, Daisy Zhang-Negrerie, and Yunfei Du.* PhI(OCOCF3)2-Mediated Construction of 2-Spiropseudoindoxyl Skeleton via Cascade Annulation of 2-Sulfonamido-N-phenylpropiolamide Derivatives. Org. Lett. 2017, 19, 902–905\r
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Ying Zhou, Xiang Zhang, Yong Zhang, Linxin Ruan, Jiacheng Zhang, Daisy Zhang-Negrerie, and Yunfei Du* Iodocyclization of N-Arylpropynamides Mediated by Hypervalent Iodine Reagent: Divergent Synthesis of Iodinated Quinolin-2-ones and Spiro[4,5]trienones. Org. Lett. 2017, 19, 150–153.\r
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Yang Cao, Xiang Zhang, Guangyu Lin, Daisy Zhang-Negrerie, and Yunfei Du* Chiral Aryliodine-Mediated Enantioselective Organocatalytic Spirocyclization: Synthesis of Spirofurooxindoles via Cascade Oxidative C-O and C-C Bond Formation. Org. Lett. 2016, 18，5580–5583.\r
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Guangchen Li, Guangshuai Zhou, Daisy Zhang-Negrerie, Yunfei Du,* Jianhui Huang,* Kang Zhao. Pd(OAc)2-Catalyzed Dual C-H Functionalization and C-C Bond-Forming: A Domino Reaction for the Synthesis of Functionalized (E)-Bisindole-2-ones from Diarylbut-2-ynediamides. Adv. Synth. Catal. 2016, 358, 3534-3540.\r
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Xiang Zhang, Guangshuai Zhou, Yong Zhang, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao.* A Ring-contraction Disproportionation-Spirocyclization Cascade Reaction of Isochromeno[4,3-b]indol-5(11H)-ones: Synthesis of N-Unsubstituted Spirocycles. J. Org. Chem. 2016, 81, 11397–11403.\r
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Xiang Zhang, Ying Cong, Kunhua Lei, Xuliang Guo, Yang Cao, Kunhua Lei and Yunfei Du.* Recent Advances of the Application of Organoiodine(III) Reagents in the Construction of Heterocyclic Compounds. Chin. J. Org. Chem. 2016, in press.[Invited review]\r
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Jiyun Sun, Daisy Zhang-Negrerie, Yunfei Du,* and Kang Zhao.* Hypervalent Reagents for Heterocycle Synthesis and Functionalization. Reports in Org. Chem. 2016, 2016, 25-45. [Invited review]\r
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Yang Cao, Hui Zhao, Daisy Zhang-Negrerie, Yunfei Du,* and Kang Zhao,* Metal-free Synthesis of 3-Arylquinolin-2-ones from N,2-Diaryl- acrylamides via PhI(O2CtBu)2-Mediated Direct Oxidative C–C Bond Formation. Adv. Synth. Catal. 2016, 358, 2016, 3610-3615.\r
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Junchao Yu, Daisy Zhang-Negrerie, and Yunfei Du.* Cu(OAc)2-Mediated Cascade Annulation of Diarylalkyne Sulfonamides through Dual C-N Bond Formation: Synthesis of 5,10-Dihydroindolo[3,2-b]indoles. Org. Lett. 2016, 18, 3322–3325.—one of a “most read” articles in July.（Highlighted by SYNFACTS, 2016,18, 3322 – 3325）.\r
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Longyang Dian, Hui Zhao, Daisy Zhang-Negrerie, and Yunfei Du.* Cobalt-Catalyzed Regioselective Twofold Direct C(sp2)–C(sp3) Bond Coupling: Late-Staged C3-Alkylation of Coumarins with Alkyl Ethers. Adv. Synth. Catal. 2016, 358, 2422–2426.\r
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Le Liu, Tonghuan Zhang, Yun-Fang Yang, Daisy Zhang-Negrerie, Xinhao Zhang, Yunfei Du,* Yun-Dong Wu,* and Kang Zhao.* Metal-free Synthesis of 3-Arylquinolin-2-ones from Acrylic Amides via PIFA-Mediated C-C Bond Formation and 1,2-Aryl Migration: An Experimental and Computational Study. J. Org. Chem. 2016, 81, 4058–4065.\r
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Jiyun Sun, Daisy Zhang-Negrerie, and Yunfei Du,* Oxidative Coupling of Enamines and Disulfides via TBAI/TBHP-Mediated Intermolecular Oxidative C(sp2)-S Bond Formation Under Transition-metal Free Conditions. Adv. Synth. Catal. 2016, 358, 2035–2040.\r
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Liu Yang, Daisy Zhang-Negrerie, Kang Zhao, and Yunfei Du.* Intramolecular Functionalization of sp3 C-H Bonds Adjacent to the Nitrogen in N-Aryl Tetrahydroisoquinoline Derivatives under Transition Metal-Free Conditions. J. Org. Chem. 2016, 81, 3372–3379.\r
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Junchao Yu, Daisy Zhang-Negrerie, and Yunfei Du.* TBHP/CoCl2-Mediated Intramolecular Oxidative Cyclization of N-(2-Formylphenyl)amides: A Novel Approach to the Construction of 4H-3,1-Benzoxazin-4-ones. Eur. J. Org. Chem. 2016, 2016, 562-568.