个人简历
Education Experience 2002-2006 Bachelor of Science Biophysics Nanjing University 2006-2013 Ph. D. Biology Tsinghua University Professional Experience 2013-now Lecturer Tianjin University
研究领域
Dr. Chen focuses on exploring the functions of critical replicase proteins involved in the pathogenesis of life-threatening pathogens (Cytomegalovirus, Coronaviruses and Enterovirus 71, etc.) employing the structural biology approaches. He also performs structure-based inhibitor design, aiming at developing effective antiviral lead compounds. As shown below, Fig. 1 illustrates the crystal structure of Enterovirus 71 RNA-dependent RNA polymerase in complex with its primer precursor peptide VPg. Fig. 2 depicts the structure of feline infectious peritonitis virus main protease in complex with a structure-based inhibitor N3.
近期论文
Yuna Sun#, Yaxin Wang#, Chao Shan#, Cheng Chen, Peng Xu, Mohan Song, Honggang Zhou, Cheng Yang, Wenbo Xu, Pei-Yong Shi, Bo Zhang*, and Zhiyong Lou*, Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase. Journal of virology, 2012, 86(24): 13662-13671. Cheng Chen#, Yaxin Wang#, Chao Shan#, Yuna Sun, Peng Xu, Honggang Zhou, Cheng Yang, Pei-Yong Shi, Zihe Rao, Bo Zhang*, and Zhiyong Lou*, Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation. Journal of virology, 2013, 87(10): 5755-5768. Wang J#, Wang F#, Tan Y, Chen X, Zhao Q, Fu S, Li S*, Chen C*, Yang H. Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor. Acta Crystallogr F Struct Biol Commun, 2014, 70(Pt 12): 1612-1615. Xia Chen#, Yusheng Tan#, Fenghua Wang, Jinshan Wang, Qi Zhao, Shuang Li, Sheng Fu*, Cheng Chen*, and Haitao Yang, Expression, crystallization and preliminary crystallographic study of the functional mutant (N60K) of nonstructural protein 9 from Human coronavirus HKU1. Acta crystallographica Section F, Structural biology communications, 2014, 70(12): 1620-1623. Fenghua Wang#, Cheng Chen#, Xuemeng Liu, Kailin Yang, Xiaoling Xu*, Haitao Yang*. The crystal structure of feline infectious peritonitis virus main protease in complex with synergetic dual inhibitors. J Virol, 2015. (Epub) (#Co-first author, *Corresponding author, same as below)
