个人简历

教育经历:
1993.9-1998.7：延边大学医学院，临床医学，学士
2000.9-2003.7：延边大学医学院， 药理学， 硕士
2004.3-2006.2：韩国庆熙大学医学院，药理学，博士
工作经历:
1998.7-2004.2：延边大学医学院，药理教研室，助教
2006.3-2007.2：韩国庆熙大学医学院，药理学，博士后
2008.3-2009.12：韩国庆北大学医学院，药理学，博士后
2010.1-2018.7：苏州大学药学院，药理系，副教授
2018.7-至今：苏州大学药学院，药理系，教授

研究领域

1.神经胶质细胞（microglia，astrocytes）激活调控的机制。
2.胶质细胞介导神经炎症在神经退行性疾病中作用。
3.发现新的治疗神经炎症靶点及其抑制剂。

近期论文

(1)Gu R, Zhang F, Chen G, Han C, Liu J, Ren Z, Zhu Y, Waddington JL, Zheng LT*, Zhen X*.Clk1 deficiency promotes neuroinflammation and subsequent dopaminergic cell death through regulation of microglial metabolic reprogramming. Brain Behav Immun. 2016 Oct 18. pii: S0889-1591(16)30484-6. (通讯作者)
(2)Zhang Y, Gu R, Jia J, Hou T, Zheng LT*, Zhen X*. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity suppresses microglia-mediated inflammatory responses. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1134-1144. (通讯作者)
(3)Chen H, Han C, Wu J, Liu X, Zhan Y, Chen J, Chen Y, Gu R, Zhang L, Chen S, Jia J, Zhen X*, Zheng LT*, Jiang B. Accessible Method for the Development of Novel Sterol Analogues with Dipeptide-like Side Chains That Act as Neuroinflammation Inhibitors. ACS Chem Neurosci. 2016 Mar 16;7(3):305-15. (通讯作者)
(4)Gan P, Zhang L, Chen Y, Zhang Y, Zhang F, Zhou X, Zhang X, Gao B, Zhen X, Zhang J*, Zheng LT*. Anti-inflammatory effects of glaucocalyxin B in microglia cells. J Pharmacol Sci. 2015 May;128(1):35-46. (通讯作者)
(5) Liu TY, Yang XY, Zheng LT, Wang GH, Zhen XC. Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death. J Neurochem. 2016 Nov 27
(6) Wang Y, Guo L, Jiang HF, Zheng LT, Zhang A, Zhen XC. Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity. CNS Neurosci Ther. 2016 May;22(5):368-77.
(7)Xu Z, Wu J, Zheng J, Ma H, Zhang H, Zhen X, Zheng LT*, Zhang X*. Design, synthesis and evaluation of a series of non-steroidal anti-inflammatory drug conjugates as novel neuroinflammatory inhibitors. Int Immunopharmacol. 2015 Apr;25(2):528-37. (通讯作者)
(8)Wu J, Du J, Gu R, Zhang L, Zhen X, Li Y, Chen H, Jiang B*, Zheng LT*. Inhibition of neuroinflammation by synthetic androstene derivatives incorporating amino acid methyl esters on activated BV-2 microglia. ChemMedChem . 2015.10, 610-616. (通讯作者)
(9) Wu Z, Li L, Zheng LT, Xu Z, Guo L, Zhen X. Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation. J Neurochem. 2015 Sep;134(5):904-14.
(10)Zhou X, Gan P, Hao L, Tao L, Jia J, Gao B, Liu JY, Zheng LT*, Zhen X*. Antiinflammatory effects of orientin-2\