个人简历

章良，苏州大学药学院生物制药系教授，主要从事肿瘤免疫学研究。2005年6月在中国药科大学生命科学与技术学院获得微生物与生化药学博士学位， 2007年进入苏州大学医学生物技术研究所博士后流动站做博士后，2014年赴美Mayo clinic免疫学系进行访问学者研究工作。担任plos one, Science Publishing Group审稿人。

研究领域

目前致力于研究共刺激家族分子在肿瘤免疫逃逸中的作用及其靶向治疗的机制，发现负性共刺激分子B7-H4及B7-H1不仅可表达在细胞膜表面抑制T细胞的激活，也可以转移到细胞核促进肿瘤的增殖和转移，为负性共刺激分子在肿瘤中的作用研究提供了理论基础。

近期论文

1、L Zhang, H Wu, D Lu, G Li, C Sun, H Song, et al. The costimulatory molecule B7-H4 promote tumor progression and cell proliferation through translocating into nucleus. Oncogene, 2013, 32(46):5347-5358.
2、Xu R, Zeng S, Xie W, Sun C, Chen YL, Chen MJ, Zhang L. The expression and function of Frizzled-7 in human renal cell carcinoma. Clinical and Translational Oncology, 2016, 18(3): 269-76.
3、Chuangyang Sun, Hui Song, Hua Zhang, Chuansheng Hou, Tianhang Zhai, Lv Huang,Liang Zhang. CD133 expression in renal cell carcinoma (RCC) is correlated with nuclear hypoxia-inducing factor 1α(HIF-1α). Journal of Cancer Research and Clinical Oncology,2012 138(10):1619-1624.(通讯作者)
4、Yong-Yan Bei, Xiao-Feng Zhou, Ben-Gang You, Zhi-Qiang Yuan, Wei-Liang Chen, Peng Xia, Yang Liu, Yong Jin, Xio-Juan Hu, Qiao-Ling Zhum Chun-Ge Zhang, Xue-Nong Zhang, Liang Zhang. Application of the central composite design to optimize the preparation of novel micelles of harmine. International Journal of Nanomedicine, 2013,8: 1795-1808.(通讯作者)
5、Chuan Y Sun, Ya C Zang, Yu X San, Wei Sun, Liang Zhang. Proteomic analysis of clear cell renal cell carcinoma. Saudi Med J, 2010, 31(5):525-532.（通讯作者）
6、Yong-Yan Bei, Zhi-Qiang Yuan, Liang Zhang, et al. Novel self-assembled micelles based on palmitoyl-trimethyl-chitosan for efficient delivery of harmine to liver cancer. Expert Opinion on Drug Delivery, 2014,11(6):843-854.
7、Liang Zhang,Li-Jun Wei. ACTX-8, a cytotoxic L-amino acid oxidase isolated from Agkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells. Life sciences, 2007 ，80（13):1189-1197.
8、Liang Zhang, Li Cui. A cytotoxin isolated from Agkistrodon acutus snake venom induces apoptosis via Fas pathway in A549 cells. Toxicology in vitro, 2007，21（6）:1095-1103.
9、Liang Zhang, Wu-Tong Wu. Isolation and characterization of ACTX-6: a cytotoxic L-Amino Acid Oxidase from Agkistrodon acutus snake venom. Natural product research, 2008，22（6）：554-563.