个人简历

学习经历：
2004.09-2008.07 内蒙古大学，本科
2008.09-2013.07 中国科学技术大学，博士
研究经历：
2013.10-2016.03 美国国立卫生研究院， 博士后
2016.08-2019.07 苏州大学助理研究员
2019.07-至今 苏州大学副研究员

研究领域

蛋白质降解和修饰
神经相关疾病的分子机制

近期论文

1.Gu X※, Mao X※, Lussier MP※, Hutchison MA※, Zhou L, Hamra FK, Roche KW, Lu W. GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nature Communications7,10873 (2016).
2.Gu X, Zhou L, Lu W. An NMDA receptor-dependent mechanism underlies inhibitory synapse development.Cell Reports 14, 471-478 (2016)
3.Zhou L※, Wang H※, Ren H, Hu Q, Ying Z, Wang G. Bcl-2 decreases the affinity of SQSTM1/p62 to Poly-Ubiquitin chains and suppresses the aggregation of misfolded protein in Neurodegenerative disease. Molecular Neurobiology 52, 1180-1189 (2015).
4.Zhou L, Wang H, Chen D, Gao F, Ying Z, Wang G. p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine. International Journal of Molecular Sciences15, 14997-15010 (2014).
5.Zhou L, Wang H, Wang P, Ren H, Chen D, Ying Z, Wang G. Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax. Neuroscience 243, 14-21 (2013).
6.Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH. Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacologica Sinica 34, 651-656 (2013).

7.Wang P, Li B, Zhou L, Fei E, Wang G. The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins. Neuroscience 190, 43-55 (2011).