个人简历

研究领域

"""""主要从事生物医用高分子和药物递送系统的开发并研究其在肿瘤、炎症、自身免疫性疾病治疗中的应用。"

近期论文

1. Rujing Zhang, Nan Zheng, Ziyuan Song, Lichen Yin*, Jianjun Cheng*. The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides. Biomaterials, 2014, 35, 3443-3454.\r
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2. Lichen Yin ♯, Xin Zhao♯, Shizhao Ji, Chunbai He, Guangyi Wang*, Cui Tang*, Shaohua Gu*, Chunhua Yin. The use of gene activated matrix to mediate effective SMAD2 gene silencing against hypertrophic scar. Biomaterials, 2014, 35, 2488-2498.\r
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3. Nan Zheng#, Lichen Yin#, Ziyuan Song, Liang Ma, Haoyu Tang, Nathan P. Gabrielson, Hua Lu, Jianjun Cheng*. Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting. Biomaterials, 2014, 35, 1302-1314.\r
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4. Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Nathan P. Gabrielson, Jianjun Cheng*. Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes. Adv Mater, 2013, 25, 3063-3070.\r
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5. Lichen Yin♯, Haoyu Tang#, Kyung Hoon Kim, Nan Zheng, Ziyuan Song, Nathan P. Gabrielson, Hua Lu, Jianjun Cheng*. Trigger-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: toward nonviral gene delivery. Angew Chem Int Ed, 2013, 52, 9182-9186.\r
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6. Lichen Yin, Ziyuan Song, Qiuhao Qu, Kyung Hoon Kim, Nan Zheng, Catherine Yao, Isthier Chaudhury, Haoyu Tang, Nathan P. Gabrielson, Fatih M. Uckun, Jianjun Cheng*. Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation. Angew Chem Int Ed, 2013, 52, 5757–5761.\r
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7. Haoyu Tang#, Lichen Yin#, Kyung Hoon Kim, Jianjun Cheng*. Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties. Chem Sci, 2013, 4, 3839-3844.\r
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8. Chunbai He♯, Lichen Yin ♯, Cui Tang*, Chunhua Yin. Trimethyl chitosan-cysteine nanoparticles for systemic delivery of TNF-α siRNA via oral and intraperitoneal routes. Pharm Res, 2013, 30:2596-2606.\r
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9. Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Haoyu Tang, Hua Lu, Nathan P. Gabrielson, Jianjun Cheng*. Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery. Biomaterials, 2013, 34, 2340-2349.\r
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10. Chunbai He♯, Lichen Yin ♯, Cui Tang*, Chunhua Yin. Multifunctional polymeric nanoparticles for oral delivery of TNF-α siRNA to macrophages. Biomaterials, 2013, 34, 2843-2854.\r
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11. Zhonghai Zhang♯, Lichen Yin♯, Chunlai Tu, Ziyuan Song, Yanfeng Zhang, Yunxiang Xu, Rong Tong, Qin Zhou, Jie Ren*, Jianjun Cheng*. Redox-responsive, core cross-linked polyester micelles. ACS Macro Lett, 2013, 2, 40-44.\r
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12. Zhonghai Zhang ♯, Lichen Yin ♯, Yunxiang Xu, Rong Tong, Yanbing Lu, Jie Ren*, Jianjun Cheng*. Facile functionalization of polyesters through thiol-yne chemistry for the design of degradable, cell-penetrating and gene delivery dual-functional agents. Biomacromolecules, 2012, 13, 3456-3462.\r
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13. Lichen Yin, Jieying Ding, Jing Zhang, Chunbai He, Cui Tang*, Chunhua Yin*. Polymer integrity related absorption mechanism of superporous hydrogel containing interpenetrating polymer networks for oral delivery of insulin. Biomaterials, 2010, 31, 3347-3356.\r
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14. Xin Zhao♯, Lichen Yin♯, Jieying Ding, Cui Tang, Shaohua Gu, Chunhua Yin*, Yumin Mao*. Thiolated trimethyl chitosan nanocomplexes as gene carriers with high in vitro and in vivo transfection efficiency. J Control Release, 2010, 144, 46-54.\r
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15. Lichen Yin, Jieying Ding, Chunbai He, Liming Cui, Cui Tang*, Chunhua Yin*. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials, 2009, 30, 5691-5700.\r
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16. Lichen Yin, Xin Zhao, Liming Cui, Jieying Ding, Miao He, Cui Tang*, Chunhua Yin*. Cytotoxicity and genotoxicity of superporous hydrogel containing interpenetrating polymer networks. Food Chem Toxicol, 2009, 47, 1139-1145.\r
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17. Lichen Yin, Ziming Zhao, Yizhe Hu, Jieying Ding, Fuying Cui, Cui Tang*, Chunhua Yin*. Polymer–protein interaction, water retention, and biocompatibility of a stimuli-sensitive superporous hydrogel containing interpenetrating polymer networks. J Appl Polym Sci, 2008, 108, 1238-1248.\r
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18. Lichen Yin, Jieying Ding, Likun Fei, Miao He, Fuying Cui, Cui Tang*, Chunhua Yin*. Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles. Int J Pharmaceut, 2008, 350, 220-229.\r
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19. Lichen Yin, Likun Fei, Cui Tang*, Chunhua Yin*. Synthesis, characterization, mechanical properties and biocompatibility of interpenetrating polymer network–superporous hydrogel containing sodium alginate. Polym Int, 2007, 56, 1563-1571.\r
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20. Lichen Yin, Likun Fei, Fuying Cui, Cui Tang*, Chunhua Yin*. Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks. Biomaterials, 2007, 28, 1258-1266.