个人简历

杨巍，苏州大学医学部放射医学与防护学院放射生物教研室教授。1998年6月本科毕业于白求恩医科大学临床医学系，2005年6月博士毕业于吉林大学白求恩医学部卫生部放射生物学重点实验室。曾先后赴奥地利维也纳畜牧医药大学医用化学研究所、日本原子能机构高崎放射研究所、美国麻省总医院放射肿瘤学系和哈佛大学公共卫生学院John B. Little辐射研究中心访学。主要从事肿瘤放射增敏研究，迄今为止，主持国家自然科学基金项目4项，以第一或通讯作者发表SCI论文14篇，其中一区论文3篇，二区论文5篇。获授权发明专利1项；主编国家重点学科放射医学系列教材一部。

研究领域

1. 乏氧肿瘤细胞放射增敏研究
2. 肿瘤干细胞放射增敏研究
3. 非编码RNA与肿瘤放射治疗研究

近期论文

1.Yang W, Liu Y, Gao R, Yu H, Sun T. HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway. Cancer Lett. 2018; 415:164-176.
2. Shen Y, Liu Y, Sun T*, Yang W*. LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway. Exp Cell Res. 2017; 358 (2): 188-198.
3. Liu Y, Shen Y, Sun T*, Yang W*. Mechanisms regulating radiosensitivity of glioma stem cells.Neoplasma. 2017; 64 (5): 655-665.
4.Yang W, Yu H, Shen Y, Liu Y, Yang Z, Sun T.MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway.Oncotarget. 2016; 7 (27): 41505-41526.
5. Shi Y, Wu W, Qiao H, Yue L, Ren L, Zhang S, Yang W*, Yang Z*.The protein PprI provides protection against radiation injury in human and mouse cells.Sci Rep. 2016 May 25;6:26664.
6. Wen L, Yue L, Shi Y, Ren L, Chen T, Li N, Zhang S, Yang W*, Yang Z*.Deinococcus radiodurans pprI expression enhances the radioresistance of eukaryotes.Oncotarget. 2016;7(13):15339-15355.
7. Yang W, Shen Y, Wei J, Liu F. MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species. Oncotarget, 2015, 6 (26), 22006-22027.
8. Yang W, Wei J, Guo T, Shen Y, Liu F. Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance. Exp Cell Res. 2014;326(1):22-35.
9.Yang W, Wei J, Sun T, Liu F. Effects of knockdown of miR-210 incombination with ionizing radiation on human hepatoma xenograft in nude mice.Radiat Oncology. 2013, 8:102.
10.Yang W, Sun T, Cao J, Liu F, Tian Y, Zhu W. Downregulation of miR-210 expression inhibitsproliferation, induces apoptosis and enhances radiosensitivity in hypoxic humanhepatoma cells in vitro. Exp Cell Res. 2012, 318(8):944-954.
11.Yang W, Sun T, Cao J,Fan S. Hypoxia-InducibleFactor-1α Downregulation by Small Interfering RNA Inhibits Proliferation,Induces Apoptosis, and Enhances Radiosensitivity in Chemical Hypoxic HumanHepatoma SMMC-7721 Cells. Cancer BiotherRadiopharm. 2011, 26 (5): 565-571.
12.Wei Yang, Ting Sun, Jianping Cao, FenjuLiu. Survivin downregulation by siRNA/cationic liposome complex radiosensitizeshuman hepatoma cells in vitro and in vivo. Int J Radiat Biol, 2010, 86 (6):445-457.
13.Wei Yang, Jingguo Zhao, Xiuyi Li,Shouliang Gong, Jianping Cao. Anti-tumor effect of 125I-UdR in combination with Egr-1 promoter-based IFNγ gene therapyin vivo. Radiat Environ Biophys,2010, 49 (4): 705-714.
14. Yang Wei, Li Xiuyi. Anti-tumor effect of pEgr-IFNγ-Endostatin gene-radiotherapy in mice bearing Lewis lung carcinoma and its mechanism. Chin Med J. 2005; 118(4):296-301.