个人简历

学历背景：
1979.9－1984.7 苏州医学院大学本科
1987.9－1990.7 苏州医学院药理学硕士生
1995.9－1998.7 中国中医科学院中西医结合心血管内科博士生, Ph.D
1999.3－2001.2 上海中医药大学博士后研究人员
工作经历：
1984.7－1987.9 苏州医学院药理教研室助教
1990.7－1995.9 苏州医学院药理教研室助教、讲师
1998.7－1999.2 苏州医学院药理教研室副教授
2001.2－现在 苏州大学教授,2004年始任博导

研究领域

（1）心血管药理学
（2）调脂与抗炎药物的分子机制研究
（3）天然药物作用及相关机制研究

近期论文

1. Rong Chen, Jie Xue, Mei-Lin Xie*. Reduction of isoprenaline- induced myocardial TGF-β1 expression and fibrosis in osthole- treated mice. Toxicology and Applied Pharmacology, 2011, 256: 168-173.
2. Rao Du, Jie Xue, Heng-bin Wang, Yan Zhang, Mei-lin Xie*. Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression. European Journal of Pharmacology, 2011, 666: 183-188.
3. Zhigang Qi, Jie Xue, Yan Zhang, Hengbin Wang, Meilin Xie*. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats. Planta Medica, 2011, 77: 231-235.
4. Jianjun Zhang, Jie Xue, Hengbin Wang, Yan Zhang and Meilin Xie*. Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress. Phytotherapy Research, 2011, 25:638-643.
5. Jie Xue, Yinan Hua, Meilin Xie*, Zhenlun Gu. Aspirin inhibits MMP-9 mRNA expression and release via the PPARα/γ and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomedicine & Pharmacotherapy, 2010, 64: 118-123.
6. Fan Sun, Mei-lin Xie*, Jie Xue, Heng-bin Wang. Osthole regulates hepatic PPARα-mediated lipogenic gene expression in alcoholic fatty liver murine. Phytomedicine,2010,17: 669-673.
7. Yinan Hua, Jie Xue, Fan Sun, Lujia Zhu, Meilin Xie*. Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARα/γ and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology, 2009,83(1):18-25.
8. Yiqin Yao, Meilin Xie*, Jie Xue, Keping Zhang. Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARα/γ and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages. Inflammation, 2009,32:233-241.
9. Fan Sun, Meilin Xie, Lujia Zhu, Jie Xue, Zhenlun Gu. Inhibitory effect of osthole on alcohol-induced fatty liver in mice. Digestive and Liver Disease, 2009,41:127-133.
10.Yan Zhang, Mei-lin Xie*, Jie Xue, Zhen-lun Gu. Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARa/γ in fat milk-induced fatty liver rats. Journal of Asian Natural Products Research, 2008, 10 (8): 797-802.
11.Yan Zhang, Mei-lin Xie*, Jie Xue, Zhen-lun Gu. Osthole improves fat milk-induced fatty liver in rats: Modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression. Planta Medica, 2007,73(8): 718-724.
12.Yan Zhang, Mei-lin Xie*, Lu-jia Zhu, Zhen-lun Gu. Therapeutic effect of osthole on hyperlipidemic fatty liver in rats. Acta Pharmacologica Sinica 2007,28(3):398-403.