个人简历

学历背景：
1981.9-1987.7 上海医科大学本科
1987.9-1990.7 上海医科大学组织胚胎学硕士生
1997.4-2001.3 日本东京大学医学部神经内科 Ph.D
2001.4-2001.10 新加坡国立大学博士后
2001.11-2003.8 美国依阿华大学医学院博士后
国外学习研究经历：
1995.10-1997.3 日本东京大学附属医院访问学者
工作经历：
1990.8-1995.9 上海医科大学组织胚胎学助教、讲师
2003.10-2011.5 中国科学技术大学教授、博导
2011.5-至今 苏州大学药学院教授、博导

研究领域

1）帕金森病中的线粒体损伤和清除的机制
2）帕金森病中神经元与胶质细胞相互作用在疾病发生中的作用
3）神经退行性疾病相关蛋白的功能和机制研究

近期论文

Mao J, Xia Q, Liu C, Ying Z, Wang H, Wang G. A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation. Hum Mol Genet.2017; 26: 1877-1889.
Gu C, Zhang Y, Hu Q, Wu J, Ren H, Liu CF, et al. P7C3 inhibits GSK3beta activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo. Cell Death Dis. 2017; 8: e2858.
Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z*, Wang G*. TDP-43 loss of fuction increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J.2016; 35:121-142. （封面论文）
Xia Q, , Wang H, Hu Q, Ying Z*,Wang G*. Folliculin, a tumor suppressor associated with Birt-Hogg-Dube (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation. Hum Mol Genet.2016; 25: 83-96.
Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H, Wang G*. TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners. Autophagy .2016,4,707-708.
Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*, Ying Z*. Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum Mol Genet, 2015, 24: 2426-41.
Gao F, Chen D, Si J, Hu Q, Fang M and Wang G*. Impairment of Nix-mediated mitophagy is linked to the pathogenesis of Parkinson's disease. Hum Mol Genet, 2015, 24: 2528-38.
Zhou L, Wang H, Ren H, Hu Q, Ying Z*, Wang G.* Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease.Mol Neurobiol.2015, 52:1180-9.
Xu R, Hu Q, Ma Q, Liu C, Wang G*.The protease Omi regulates mitochondrial biogenesis through the GSK3b/PGC-1a pathway. Cell Death and Dis. 2014, 5:e1373.
Ren H, Fu K, Mu C, Zhen X, Wang G*. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener. 2012, 7:40.
Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G* The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation. Science Signal.2012, 5:ra61.（封面论文，并被该杂志电话采访）
Wang H, Ying Z, Wang G* Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains.J Biol Chem. 2012, 287:28576-28585.
Ren H, Fu K, Wang D, Mu C, Wang G* Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL.J Biol Chem. 2011, 286: 35308-35317.
Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G* DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene.2011, 31:1311-1322.
Ma X, Fei E, Fu C, Ren H, Wang G* Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry.2011, 16:1105-1116.（封面论文）
Ying Z, Wang H*, Fan H, Wang G* The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin. J Biol Chem. 2011, 286: 20835-20844.
Fei E, Ma X, Zhu C, Xue T, Yan J, Xu Y, Zhou J, Wang G* Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia related protein, regulates synapsin I expression. J Biol Chem.2010 285：38630-38640.
Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G* Parkin mono-ubiquitinates BCL-2 and regulates autophagy. J Biol Chem. 2010, 285：38214-38223.
Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei N, Wang G* Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death & Differ2010, 17:1751-1759.
Ren H, Fu K, Mu C, Li B, Wang D, Wang G* DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells. Cancer Lett2010, 297:101-108.
Zhou T, Wang S, Ren H, Qi X, Luchetti S, Kamphuis W, Zhou J, Wang G* and Swaab D* Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain2010, 133: 3069-3079.
Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M, Wang G* DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity. J Biol Chem 2008, 283:4022-4030.
Liu C, Fei E, Jia N, Wang H, Tao R, Iwata A, Nukina N, Zhou J, and Wang G*Assembly of lysine 63 linked ubiquitin-conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis. J Biol Chem 2007, 282:14558-14566