个人简历

缪丽燕，教授，主任药师，博士生导师，苏州大学附属第一医院副院长，药物临床试验机构办主任、临床药学教研室主任，苏州大学药学院临床药学系主任。兼具临床和药学背景，专业主攻方向为个体化药物治疗与合理用药，尤其在基于生理病理和遗传因素的个体化给药模型、群体药动学药效学模型及药物安全性、有效性研究等方面取得了很有临床意义的研究成果，为临床药物的选择以及个体化给药方案提供依据。同时，作为卫生部国际合理用药网络（INRUD）中国中心组“个体化药物治疗组”组长单位负责人，组织各网络医院开展多中心的基因多态性与个体化药物治疗相关研究。
学习、工作经历
1984.9-1989.7 苏州医学院医学系本科 学士学位
1989.9-1992.7 广州中山医科大学药理系硕士学位
1995.9-1998.7 苏州医学院附属第一医院心血管内科博士学位
1998.7-1999.9苏州医学院附属第一医院心血管内科实验室
1999.7-2002.7 美国密西西比医学中心博士后
2002.7-至今 苏州大学附属第一医院药剂科、国家药物临床试验机构、副院长
2005.3-2006.9 清华大学国际创新管理（医院药事管理）研究生课程进修班

研究领域

1. 个体化药物治疗与合理用药；
2. 临床药理学研究；
3. 临床药物代谢动力学研究；
4. 药事管理。

近期论文

1. Zubcov A， Miao L et al. Signal Transduction of ET-1 in Contraction of Cerebral Arteries.J Cardiovasc Pharmacol. 2004 Nov; 44 Suppl 1:S24-6.
2. Sung JK，Miao L et al A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.Brain Res. 2003 Jan 3; 959(1):29-38.
3. Massey AR， Miao L et al. Increased RhoA translocation in renal cortex of diabetic rats.Life Sci. 2003 May 16; 72(26):2943-52.
4. L.Miao， J. W. Calvert， J. Tang， J. H. Zhang. Upregulation of Small GTPase RhoA in the Basilar Artery from Diabetic (mellitus) Rats. Life Science 2002. 71(10):1175-1185
5. L.Miao， Y. Dai， J. H. Zhang. Mechanism of RhoA/ROK kinase activation in endothelin-1-induced contraction in rabbit basilar artery. Am.J. Physiol Heart Circ 2002 283(3):H983-H989.
6. L. Miao， J. Calvert， J. Tang， A. Parent & J. Zhang. Age-related Rho-A expression in Blood Vessels of Rats. Mechanism of Aging and Development 122: 1757-1770，2001.
7. L. Miao， J. Tang， D. Esposito & J. Zhang. Age-related Changes of P2 Receptor mRNAs of Rat Cerebral Arteries. Experimental Gerontology 37: 67-79, 2001.
8. R. Carpenter， L. Miao， Y， Miyagi， E. Bengten & J. Zhang. Altered Expression of P(2) Receptor mRNAs in the Basilar Artery in a Rat Double Hemorrhage Model. Stroke 32: 516-522, 2001.
9. Miao L， Yang J， Huang C， Shen Z Contribution of age， body weight， and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients. Eur J Clin Pharmacol. 2007 Dec;63(12):1135-41.
10. Huang CR，Yang J， Du YH， Miao LY*. Measurement of Free Concentrations of Highly Protein-Bound Warfarin in Plasma by Ultra Performance Liquid Chromatography –Tandem Mass Spectrometry and its Correlation with the International Normalized Ratio. Clin Chim Acta， 2008， 393: 85-89.
11. Miao LY Huang CR Hou JQ Qian MY Association study of ABCB1 and CYP3A5 gene polymorphisms with sirolimus trough concentration and dose requirements in Chinese renal transplant recipients。Biopharm Drug Dispos. 2008 Jan;29(1):1-5.
12. Ling Xue， Jian-Zhong Rui， Yan Zhang， and Li-Yan Miao* Population Pharmacokinetics Study of Tacrolimus in Chinese Hematopoietic Cell Transplant Patients. Blood Nov 2009; 114: 4668.
13. J. Yang， C. Huang， Z. Shen and L. Miao Contribution of 1173C > T polymorphism in the VKORC1 gene to warfarin dose requirements in Han Chinese patients receiving anticoagulation International Journal of Clinical Pharmacology and Therapeutics， Vol. 49 – No. 1/2011 (23-29).
14. Yan Zhang ，Jin Wang， Li-Mei Zhao， Wei Peng ，Guo-Qing Shen ，Ling Xue ， Xiao-Xian Zheng ，Xiao-Jing HE ，Chun-Yan Gong， Li-Yan Mia.o*，Strong association between HLA-B*1502and carbamazepine-induced Stevens-Johnson syndromeand toxic epidermal necrolysis in mainland Han Chinese patients Eur J Clin Pharmacol. 2011 Sep;67(9):885-7.
15. Jing Deng， Enguang Feng， Sheng Ma， Yan Zhang， Xiaofeng Liu，Honglin Li， Huang Huang，Jin Zhu， Weiliang Zhu， Xu Shen， Liyan Miao*，Hong Liu， Hualiang Jiang， and Jian Li* Design and Synthesis of Small Molecule RhoA Inhibitors:A New Promising Therapy for Cardiovascular Diseases? Journal of Medicinal Chemistry 2011， 54， 4508–4522.
16. Ling Xue，Hua Zhang，Sheng Ma，Jian-Zhong Rui，Li-Yan Miao*，Population Pharmacokinetics and Pharmacogenetics of tacrolimus in Healthy Chinese Volunteers，Pharmacology 2011;88:288–294.
17. Xiao-Liang Ding,Yang-Lin Deng,Jun Zhang,Li-Yan Miao*，Mutation-Sensitive Molecular Switch Method to Detect CES1A2 Mutation in the Chinese Han and Yao Populations，GENETIC TESTING AND MOLECULAR BIOMARKERS，Volume 15, Number 9, 2011.
18. Chenrong Huang, Jie Gao, Liyan Miao*，Simultaneous determination of flucloxacillin and ampicillin in human plasma by ultra performance liquid chromatography–tandem mass spectrometry and subsequent application to a clinical study in healthy Chinese volunteers，Journal of Pharmaceutical and Biomedical Analysis 59 (2012) 157–161.
19. Zhang JJ, Zhang H, Ding XL, Ma S, Miao LY* Effect of the P450 oxidoreductase*28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteer. Eur J Clin Pharmacol. 2013 Apr;69(4):807-12.
20. Yan Zhang, Jing Deng, Sheng Ma, Lin Xue, Jin Zhu, Wei-liang Zhu, Hua-liang Jiang, Jian Li, and Li-yan Miao*，The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction，Current Pharmaceutical Design, 2012, 18, 4258-4264.